Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Design of Experiments for the Development of Topical Drug Products
The systematic development of pharmaceutical products using quality tools is highly essential for attaining robust performance by minimizing variability. Design of experiment (DoE) is now considered as an indispensable tool in…
Screening of novel excipients for freeze-dried protein formulations
The typical excipients used as bulking agents and lyoprotectants for freeze-drying are usually limited to only a few selected substances, such as sucrose and mannitol. Considering the sheer diversity amongst proteins, it is doubtful that…
Preparation, characterization and in vivo pharmacokinetic evaluation of curcuminoids-loaded solid…
Curcuminoids are considered as one of the most promising phytochemicals with numerous pharmacological effects and therapeutic potentials. Nevertheless, their inappropriate pharmacokinetic properties (i.e., poor bioavailability) have made…
A review of nanocarrier mediated drug delivery systems for posterior segment eye disease: challenges…
Posterior segment eye disease is a leading cause of irreversible vision impairment and blindness. As the unique organ for vision, eyes are protected by various protective barriers. The existence of physiological barriers and elimination…
Selecting Optimal Pharmaceutical Excipient Formulation from Life Cycle Assessment Perspectives: A…
Manufacturing of active pharmaceutical ingredients (API) is known to produce significantly larger environmental impacts than manufacturing of commodity chemicals. This prompted the pharmaceutical industry to adopt sustainable manufacturing…
Material tracking in a continuous direct capsule-filling process via residence time distribution…
Continuous production of pharmaceuticals requires traceability from the raw material to the final dosage form. With that regard, understanding the residence time distribution (RTD) of the whole process and its unit operations is crucial.…
Formulation development of SYN-004 (ribaxamase) oral solid dosage form, a β-lactamase to prevent…
SYN-004 (ribaxamase) delayed release drug product is a multi-particulate, hard capsule for oral delivery of a recombinant β-lactamase enzyme designed to degrade β-lactam antibiotics administered intravenously, and thus prevent colon…
3D-printed tablets using a single-step hot-melt pneumatic process for poorly soluble drugs
Main purpose was to evaluate the applicability of a 3D-printer equipped with a hot-melt pneumatic dispenser as a single-step process to prepare tablet dosage forms. Dutasteride, a poorly water-soluble drug, was selected as a model drug.…
How Does the Addition of Kollidon®VA64 Inhibit the Recrystallization and Improve Ezetimibe…
Amorphization serves as a strategy for the improvement of poor dissolution characteristics of many drug compounds. However, in many formulations the content of polymeric stabilizer is high, which is undesirable from the perspective of…
Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral…
Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms. Resveratrol solubility high-throughput screening with…
Niclosamide Inhalation Powder Made by Thin-Film Freezing: Pharmacokinetic and Toxicology Studies in…
In this work, we have developed and tested in vivo a dry powder form of niclosamide made by thin-film freezing (TFF) and administered it by inhalation to rats and hamsters. The niclosamide dry powder, suitable for inhalation, is being…
Research on the powder classification and the key parameters affecting tablet qualities for direct…
Direct compaction (DC) is the ideal method for tablet production. However, DC requires the highest quality powder functional properties, such as good flowability, compressibility, compactibility, and appropriate elasticity. In the present…
Interplay of Aging and Lot-to-Lot Variability on the Physical and Chemical Properties of Excipients:…
The present study investigates the chemical composition governing the physical properties of mono- and diglycerides (MDGs) at the microstructural level, as a function of aging and lot-to-lot variability. The physical structure of the MDG…
Topical Delivery of Cannabinoids with Gattefossé – Transdermal Cannabinoid Gels
There are 3 main conditions for a drug to penetrate into the skin and reach the blood circulation:
solubilization in the formulation
partition out of the vehicle
diffusion into the epidermis
Transcutol® P offers several…
Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Abstract
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS…
Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly…
Many new chemical entities have limited water solubility and therefore show low and/or variable oral bioavailability. Among the various strategies to overcome this challenge, nanoformulations have emerged as an attractive strategy to…
Phytophospholipid Complex of Caffeic Acid: Development, In vitro Characterization, and In Vivo…
Caffeic acid (CA), a hydroxycinnamic acid possessing a variety of pharmacological activities, has caused a growing interest for the treatment of hyperlipidemia and associated conditions. This work endeavored to develop a novel formulation…
Biopolymer-based nanoparticles with tunable mucoadhesivity efficiently deliver therapeutics across…
To overcome the natural barriers of the ocular system that limit the topical delivery of therapeutically active molecules to the posterior eye, nanoscale drug carriers can be used to improve transcorneal drug transport. So far, using…
Successful drug development with synthetic lipids: critical aspects and strategies
Lipids are gaining enhanced momentum due to their vital role in the field of RNA therapeutics and vaccine development for diseases such as cancer and COVID-19.
Currently, there are 18 liposomal drugs approved by the U.S. Food and Drug…
Impact of binary/ternary solid dispersion Utilizing poloxamer 188 and TPGS to improve pharmaceutical…
Bedaquiline fumarate (BDQN) is approved in year 2012 to treat multidrug resistance tuberculosis (MDR-TB) through accelerated approval pathway by FDA. It belongs to class II of biopharmaceutical classification system (BCS) and shows poor…
Preparation and Evaluation of Glaucocalyxin A Sustained- Release Pellets Based on Phospholipid…
Objective: Glaucocalyxin A (GLA) suffers from low oral bioavailability and rapid in vivo metabolism. Therefore, the purpose of this study was to develop a new formulation to enhance the oral bioavailability simultaneously sustained release…
Granutools – new website launch
All we do is powder flow characterization - See the new website of Granutools at Granutools.com
On this brand-new website, you can now navigate through the solutions designed especially for your business. Industries such as Additive…
Design of taste-masked swellable drug particles using dry-coating technology with mechanical curing
A novel dry coating technique for fine particles that does not require any liquids has been developed. Swellable ordered-mixed drug particles (Swell-OM-spheres, SOS), using a modified starch as the core particle and a drug coating layer…
Continuous blending monitored and feedback controlled by machine vision-based PAT tool
In a continuous powder blending process machine vision is utilized as a Process Analytical Technology (PAT) tool. While near-infrared (NIR) and Raman spectroscopy are reliable methods in this field, measurements become challenging when…
Electrospinning for healthcare: recent advancements
Electrospinning is a simple route to generate polymer-based fibres with diameters on the nano- to micron-scale. It has been very widely explored in biomedical science for applications including drug delivery systems, diagnostic imaging,…
Applications of polymer blends in drug delivery
Polymers are essential components of many drug delivery systems and biomedical products. Despite the utility of many currently available polymers, there exists a demand for materials with improved characteristics and functionality. Due to…
A new polymer-excipient for ethanol-resistant, sustained-release oral dosage forms
The use of alcoholic beverages can cause uncontrolled release of drugs from sustained-release solid oral dosage forms and pose severe risks to patient health. The aim of this work was to design a new polymeric excipient with ethanol…
A promising approach to design thermosensitive in situ gel based on solid dispersions of…
Desloratadine (DSL) is an anti-allergic agent but its efficacy is limited with its low dissolution rate and aqueous solubility results in restricted bioavailability. The current study examines the probability of using Kolliphor® 188 (K188)…
Ocular Drug Delivery System-based on Solid Nanoparticles
The use of eye drops is a well-established practice in the treatment of ophthalmic diseases, although the bioavailability of traditional eye drops, which are either solutions or suspensions, is insufficient, as the corneal barrier and…
Silica-filled methacrylic composites with extremely high compressive strength
SYLOID® 244 has never been applied as a filler in composites with potential dental application. Therefore, the aim of research was to apply this silica in its unmodified and diazonium salt-modified forms in different mass ratios as fillers…
Preparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for…
Background: The aim of this study is to develop a novel in situ gel of tacrolimus-loaded SLNs (solid lipid nanoparticles) for ocular drug delivery.
Methods: The optimal formulation was characterized by surface morphology, particle size,…
Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially…
Modified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study…
Formulation and stability study of hydroxychloroquine sulfate oral suspensions
Hydroxychloroquine is an antimalarial drug indicated in the treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also used for the treatment of rheumatoid…
Enhanced oral bioavailability of nintedanib esylate with nanostructured lipid carriers by lymphatic…
The present research work was aimed to explore the ability of nanostructured lipid carriers (NLCs) to improve oral bioavailability of Nintedanib esylate (NE) via lymphatic uptake. The NE loaded NLCs (NE-NLCs) were fabricated using high…