Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets
Abstract
This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv ® ODTG2, Prosolv ® EasyTab SP, and Ludiflash ® systems. For each formulation ingredient, expert…
Oral care product formulations, properties and challenges
This review explores the physical, chemical and structural properties of key components of oral care products, whilst looking at the challenges which need to be overcome to continue to improve the efficacy of oral care, and improve dental…
Innovation and Digital Tools for Better Products and Decision-Making
At the heart of a culture of quality is the desire to continually improve. From the use of digital tools to increase efficiency to innovating a leading brand to tackle tough customer challenges, DuPont continues to enhance the…
In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network…
Existing oral or injectable antipsychotic drug delivery strategies typically demonstrate low bioavailability to targeted brain regions, incentivizing the development of alternative delivery strategies. Delivery via the nasal cavity…
Polymeric Films Containing Tenoxicam as Prospective Transdermal Drug Delivery Systems: Design and…
The administration of drugs via transdermal therapeutic systems has become an attractive form of therapeutic approach, considering its advantages and the high patient compliance achieved, making them a viable alternative, especially in the…
Ideal Cures Institute of Coating Technology – Register now!
If you missed the virtual edition of Ideal Institute of Coating Technology, they’ve got you covered!
Due to popular demand, they’ve decided to do a one day virtual training on 20th January 2021 from 3:00 pm - 4:30 pm.
Register now: …
Amorphous Solid Dispersions of Felodipine and Nifedipine with Soluplus®: Drug-Polymer Miscibility…
The objective of this study was to investigate thermodynamic and kinetic miscibility for two structurally similar model compounds nifedipine (NIF) and felodipine (FEL) when formulated as amorphous solid dispersions (ASDs) with an…
Mesoporous Silica Nanoparticles for Protein Protection and Delivery
Therapeutic proteins are widely used in clinic for numerous therapies such as cancer therapy, immune therapy, diabetes management and infectious diseases control. The low stability and large size of proteins generally compromise their…
Pharmeuropa 33.1 released: don’t miss this opportunity to provide your comments
All new texts of the European Pharmacopoeia and texts that have undergone technical revisions are published in Pharmeuropa for public consultation. The deadline for comments on Pharmeuropa 33.1 is 31 March 2021.
Users and interested…
Tablet manufacturing process: Parts & Working of tablet punching machine – Virtual Video…
We provide this virtual lessons by Girish Kumar, MVN University, especially for our Indian Audience.
Learn more on tableting and tablet coating here:
Using natural alternative excipients for tableting and capsule filling
A large…
The potential gastrointestinal side effects of excipients in imatinib preparations
Chronic myeloid leukemia (CML) is a BCR-ABL positive myeloproliferative disorder characterized by clonal proliferation of the hematopoietic stem cells. Imatinib mesylate represents the most important agent associated with improved survival…
Effect of excipient particle size distribution variability on compact tensile strength; and its…
Direct compression is potentially sensitive to particle size distribution (PSD) variability in pharmaceutical grade excipients. Yet, the impact is insufficiently studied. Furthermore, the use of force sensor as a process analytical…
Nanocarrier Vaccines for SARS-CoV-2
The SARS-CoV-2 global pandemic has seen rapid spread, disease mobidities and death associated with substantive social, economic and societal impact. Treatments rely on re-purposed antivirals and immune modulatory agents focusing on…
What are the Ingredients and Excipients in the COVID-19 Vaccines? Update including Novavax Vaccine
What's in a vaccine?
With the emergence of COVID-19, the crucial role that vaccines play in protecting our health has come into sharp focus. During this pandemic hope comes in the form of a vaccine and immunologists around the world are…
Using natural alternative excipients for tableting and capsule filling
A large number of dietary supplements are available in solid oral dosage forms. Vitamin and mineral supplements can be easily pressed into tablets by wet granulation or direct compression, but such tablet formulations require good binders.…
Asahi Kasei to build a second plant for Ceolus™ microcrystalline cellulose – Press Release
Asahi Kasei's Specialty Solutions SBU will build a second plant for microcrystalline cellulose (trade name Ceolus™) at its Mizushima Works in Kurashiki, Okayama, Japan.
Asahi Kasei currently manufactures Ceolus™, a microcrystalline…
Cilostazol Solubilization and Stabilization Using a Polymer-Free Solid Dispersion System
The development of pH-independent drugs is difficult because it involves improvements in their solubility and dissolution (%) in solubilizer. In the present study, the pH-independent cilostazol (CLT) was formulated for enhanced solubility…
Development of novel darunavir amorphous solid dispersions with mesoporous carriers
The aim of this work was to compare mesoporous carriers based on silica and magnesium aluminosilicate in the amorphous solid dispersion production. Darunavir has been selected as an active pharmaceutical ingredient that is classified as a…
Advancing the Science of TUPs Management: Improved Process Controls, Enhanced Testing Methods and…
Off colored particles, also known as technically unavoidable particles (TUPs) or black specks, have presented challenges for pharmaceutical customers and excipient suppliers for decades. An inherent variability of standard testing and the…
Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in…
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential. The superior physicochemical properties of a…
Thermal Stability of Amorphous Solid Dispersions
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs. One of the major keys for successful preparation of ASD is the…
3D–Printed Zero-Order Released Platform: a Novel Method of Personalized Dosage Form Design and…
In 2017, there are 451 million people with diabetes worldwide. These figures were expected to increase to 693 million by 2045. The research and development of hypoglycemic drugs has become a top priority. Among them, sulfonylurea…
Development of a Pediatric Mini-Tablet Formulation for Expedited Preclinical Studies
Multiple considerations are essential to address the main challenges of dose flexibility and patient adherence in pediatric drug development, particularly for oncology. Mini-tablets, 2 mm in diameter, were manufactured using a rotary tablet…
Best Practices for Selection of Excipients for Paediatrics – Workshop Reflection
The development of age appropriate formulations for the paediatric population has become one of the key areas of focus for the pharmaceutical industry – with a subsequent influence on excipient use. Selection of excipients with appropriate…
Co-processing of small molecule excipients with polymers to improve functionality
Introduction
Polymers have various applications such as binder, film coating agent, stabilizer, drug release modification and as primary packaging materials. Recently, they have been explored in co-processing technique to improve the…
Development and statistical optimization of alginate-Neusilin US2 micro-composite beads to elicit…
The Alginate-Neusilin US2 micro-composite (MC) beads were fabricated and optimized for oral delivery of hesperidin (HES). A 32 full factorial design encompassing independent variables (factors) such as the concentration of sodium alginate…
mRNA vaccines — a new era in vaccinology
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has…
Multifunctional Role of Polyvinylpyrrolidone in Pharmaceutical Formulations
Polyvinylpyrrolidone (PVP), a non-ionic polymer, has been employed in multifarious fields such as paper, fibers and textiles, ceramics, and pharmaceutics due to its superior properties. Especially in pharmacy, the properties of inertness,…
Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment…
The therapeutic potential of cannabidiol (CBD) has been explored to treat several pathologies, including those in which pain is prevalent. However, the oral bioavailability of CBD is low owing to its high lipophilicity and extensive…
Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids
Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using…
Oral drug delivery systems using core–shell structure additive manufacturing technologies: a…
The aim of this study was to couple fused deposition modelling 3D printing with melt extrusion technology to produce core–shell-structured controlled-release tablets with dual-mechanism drug-release performance in a simulated intestinal…
Molecular Simulation and Statistical Learning Methods toward Predicting Drug–Polymer Amorphous Solid…
Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API solubility with various carriers in the API–carrier mixture and the…
High-Payload chitosan microparticles for the colonic delivery of quercetin: Development and in-vivo…
Quercetin, a natural flavonoid has high potential for management of inflammatory bowel diseases (IBD). However, its onset of action is delayed when administered systemically and high doses are needed for IBD treatment. The present study…
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the drugs with narrow absorption…
Starch Products as Candidate Excipients in a Continuous Direct Compression Line
Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder…