Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment…
The therapeutic potential of cannabidiol (CBD) has been explored to treat several pathologies, including those in which pain is prevalent. However, the oral bioavailability of CBD is low owing to its high lipophilicity and extensive…
Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids
Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using…
Oral drug delivery systems using core–shell structure additive manufacturing technologies: a…
The aim of this study was to couple fused deposition modelling 3D printing with melt extrusion technology to produce core–shell-structured controlled-release tablets with dual-mechanism drug-release performance in a simulated intestinal…
Molecular Simulation and Statistical Learning Methods toward Predicting Drug–Polymer Amorphous Solid…
Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API solubility with various carriers in the API–carrier mixture and the…
High-Payload chitosan microparticles for the colonic delivery of quercetin: Development and in-vivo…
Quercetin, a natural flavonoid has high potential for management of inflammatory bowel diseases (IBD). However, its onset of action is delayed when administered systemically and high doses are needed for IBD treatment. The present study…
Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery
Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the drugs with narrow absorption…
Starch Products as Candidate Excipients in a Continuous Direct Compression Line
Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder…
Stability properties and antioxidant activity of curcumin nanosuspensions in emulsion systems
In this study, curcumin nanosuspensions (Cur-NSs) were prepared using D-alpha-tocopheryl polyethylene glycol succinate (vitamin E TPGS), and their physical properties (i.e., particle size, dispersion stability) were investigated. Also, the…
A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets
There is a clear need for a robust process analytical technology tool that can be used for on-line/in-line prediction of dissolution and disintegration characteristics of pharmaceutical tablets during manufacture. Tablet porosity is a…
Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug…
Numerous diseases have been reported to affect the lymphatic system. As such, several strategies have been developed to deliver chemotherapeutics to this specific network of tissues and associated organs. Nanotechnology has been exploited…
Enteric Hard Capsules for Targeting the Small Intestine: Positive Correlation between In Vitro…
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were…
Influence of Plasticizers on the pH-Dependent Drug Release and Cellular Interactions of…
Vaginal films featuring the pH-dependent release of tenofovir (TFV) were developed for the prevention of sexual transmission of human immunodeficiency syndrome (HIV). Films based on hydroxypropyl methylcellulose and zein were prepared…
Pharmatrans SANAQ® SL 004 co-processed Starch/Lactose excipient
Pharmatrans Sanaq now offers SANAQ® SL 004 as a co-processed excipient based on mix 15/85 of maize starch and lactose monohydrate.
SL 004 forms an ultra-uniform and highly compressible lactose excipient for tablet fillings that supports…
Lipid-based formulations: winning strategy for oral bioavailability enhancement
Many drugs exhibit poor solubility and/or permeability leading to weak oral bioavailability. To overcome these issues different technologies have been developed. Among them, lipid-based formulation (LBF) is a worth-considering option as it…
Development of Itraconazole-Loaded Polymeric Nanoparticle Dermal Gel for Enhanced Antifungal…
Fungal infection of the skin is one of the most common dermatological diseases in the world. Gel formulations are among the most suitable dosage forms for topical use to treat cutaneous infection. Nanotechnology is a promising approach to…
DRcaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical…
Probiotics and enzymes are sensitive to acid and run the risk of being rendered less effective while crossing the low pH of the stomach on their way to the intestinal tract. That is why, Capsugel® performed a gamma-scintigraphy study that…
Nanostructured lipid carriers as a strategy for encapsulation of active plant constituents:…
Active plant constituents obtained from edible sources have manifested their pharmacological potential as a therapy against several diseases. But the lack of their desired physicochemical properties such as solubility, permeability…
Biopolymer Coatings for Biomedical Applications
Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and…
Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal administration could be used to improve antibiotic delivery…
In-Silico Screening of Lipid-Based Drug Delivery Systems
Purpose
This work proposes an in-silico screening method for identifying promising formulation candidates in complex lipid-based drug delivery systems (LBDDS).
Method
The approach is based on a minimum amount of experimental data for…
Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
The treatment of various central nervous system (CNS) diseases has been challenging, despite the rapid development of several novel treatment approaches. The blood–brain barrier (BBB) is one of the major issues in the treatment of CNS…
Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug…
Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as…
Maintaining Safety with SARS-CoV-2 Vaccines
Review article by Mariana C. Castells, M.D., Ph.D., and Elizabeth J. Phillips, M.D. in The NEW ENGLAND JOURNAL of MEDICINE
To date, the development of mRNA vaccines for the prevention of infection with the severe acute respiratory…
3D Printing of Core–Shell Capsule Composites for Post‐Reactive and Damage Sensing Applications
3D printing of multicomponent materials as an advantageous method over traditional mold casting methods is demonstrated, developing small core–shell capsule composites fabricated by a two‐step 3D printing process. Using a two‐print‐head…
Bio-Based Polyricinoleate and Polyhydroxystearate: Properties and Evaluation as Viscosity Modifiers…
This paper aims to design bio-based polyester as a viscosity modifier for lubricant properties. Bio-based polyricinoleate (PRic) and its saturated homologous polyhydroxystearate (PHS) have been synthesized from fatty acid methyl esters.…
Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19
The present work aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity of propolis against COVID-19. Docking studies were performed for certain components of Egyptian Propolis using Avigan,…
An Investigation into the Relationship between Xanthan Gum Film Coating Materials and Predicted…
Oral drug therapy is generally provided in the form of solid oral dosage forms (SODF) that have to be swallowed and move throughout the oro-esophageal system. Previous studies have provided evidence that the oro-esophageal transit of SODF…
A clever combination: galenIQ™ enhances the taste and formulation properties of vitamin D…
A clever combination
galenIQ™ enhances the taste and formulation properties of vitamin D supplements
Winter is here and the days are short. This means a lack of direct sunlight and, in turn, depleting levels of vitamin D in the body. In…
New Drugs Approvals by FDA and EMA: 2020 Recap
The year 2020 was an eventful year for the pharmaceutical industry, with several companies across the world working at a feverish pace to find a treatment or a vaccine for the raging Covid-19, which has so far taken over 1.79 million lives…
EUDRAGIT® E 100, EUDRAGIT® E PO and EUDRAGIT® E 12,5
The EUDRAGIT® portfolio of functional polymers delivers unrivalled versatility and reliability to help protect your API, boost drug product effectiveness and reduce formulation risk. With a proven record for safe applications that spans…
Tablets Solid Dosage Form – Virtual Video Lessons in Hindi & English by Dr. Tarun Virmani
We provide this virtual lessons by Dr. Tarun Virmani, Associate Professor, MVN University, especially for our Indian Audience.
A tablet is a pharmaceutical oral dosage form (oral solid dosage, or OSD) or solid unit dosage form.…
‘Cannabis’ ontologies I: Conceptual issues with Cannabis and cannabinoids terminology
Objective: Identify a coherent nomenclature for Cannabis sativa L. derived products and their analogues.
Design: Research undertaken in parallel to the three-year assessment of Cannabis derivatives by the World Health Organisation. The…
Evaluation of Gelling Behavior of Natural Gums and their Formulation Prospects
Purpose: Gums and polymers can be found abundantly in the nature from various plants, microbial and marine sources. Their physical and functional characteristics can be customized according to its application in product development. The…
Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral…
Oral drug administration provided as solid oral dosage forms (SODF) remains the major route of drug therapy in primary and secondary care. There is clear evidence for a growing number of clinically relevant swallowing issues (e.g.,…