Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
The Phospholipid Research Center Current Research in Phospholipids and Their Use in Drug Delivery
This review summarizes the research on phospholipids and their use for drug delivery related to the Phospholipid Research Center Heidelberg (PRC). The focus is on projects that have been approved by the PRC since 2017 and are currently…
Have a look at BASFs virtual pharma assistant RegXcellence®
BASF created the virtual pharma assistant RegXcellence® to ensure customers are always in compliance. RegXcellence®’s self-service download center gives users 24/7 access to regulatory and compliance documentation. RegXcellence® alerts…
Integrated Twin-Screw Wet Granulation, Continuous Vibrational Fluid Drying and Milling: A fully…
Highly homogeneous low-dose (50 µg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated Continuous Manufacturing (CM) line. The adopted CM equipment consisted of a Twin-Screw Wet Granulator…
Orally Disintegrating Tablets? HiSORAD – Directly Compressible Excipient for ODTs –…
HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between orally disintegration time and tablet hardness. HiSORAD enables to produce ODTs by direct compression…
3D printing of gummy drug formulations composed of gelatin and an HPMC-based hydrogel for pediatric…
The 3D printing of drug formulations is a promising method for preparing tailored medicines following the approval of 3D printed tablets by the US FDA in 2015. Appropriate dosage forms for pediatric patients are deficient because drugs have…
Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress
Global cancer prevalence has continuously increased in the last decades despite substantial progress achieved for patient care. Cancer is no longer recognized as a singular disease but as a plurality of different ones, leading to the…
Selective laser sintering (SLS) technique for pharmaceutical applications—Development of high dose…
The paper presents the unique approach to 3D printing by Selective Laser Sintering of high dose controlled release pharmaceutical dosage form, which contains almost exclusively drug substance - just crystalline paracetamol as a model drug…
Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection
Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on this solubilization interplay using proton nuclear…
3D printing of patient-tailored SNEDDS-based suppositories of lidocaine
Personalized drug delivery systems are considered an interesting perspective of the 3D printing technology, with the potential to counterbalance the pharmacological and adverse effects of pharmaceutical products. Our study was focused on…
Friday’s Top 5 by pharmaexcipients
Story of the week
ExciPerience - March 9 & 10, 2021 - We welcome our first sponsors!
We are very happy to announce the first sponsors of the upcoming new event on and around pharmaceutical excipients - ExciPerience! Thank you for…
Development and Study of Nanoemulsions and Nanoemulsion-Based Hydrogels for the Encapsulation of…
Biocompatible nanoemulsions and nanoemulsion-based hydrogels were formulated for the encapsulation and delivery of vitamin D3 and curcumin. The aforementioned systems were structurally studied applying dynamic light scattering (DLS),…
Dissolution Enhancement and Controlled Release of Paclitaxel Drug via a Hybrid Nanocarrier Based on…
In the present work, the porous metal-organic framework (MOF) Basolite®F300 (Fe-BTC) was tested as a potential drug-releasing depot to enhance the solubility of the anticancer drug paclitaxel (PTX) and to prepare controlled release…
See the new version of the virtual formulation assistant ZoomLab™
A new version of the virtual formulation assistant ZoomLab™ is now available! The latest version includes an enhanced Formulation Wizard and other usability improvements. The Formulation Wizard, which is the assistant’s guided formulation…
Development of gastroretentive floating granules with gentian root extract by hot-melt granulation
The roots of yellow gentian, Gentiana lutea L. (Gentianaceae) are used in traditional medicine for the treatment of gastrointestinal disorders, with the literature data indicate a local gastric effect of gentian root extract (GRE) and…
Investigation of propellant-free aqueous foams as pharmaceutical carrier systems
Due to their light consistency and good spreadability, aqueous foams are considered as convenient and highly accepted drug carrier systems that are of great importance in the field of topical drug delivery. The production of a stable, easy…
Vicissitudes of liquid crystals for solubility enhancement of poorly soluble drugs
A drug product should have aqueous solubility to avoid bioavailability issues. Low and erratic bioavailability is a problem encountered by almost 40–60% of new drug products coming out of research and development which are aimed to be…
Comparison of Amorphous Solid Dispersions of Spironolactone Prepared by Spray Drying and…
This research aimed to compare two solvent-based methods for the preparation of amorphous solid dispersions (ASDs) made up of poorly soluble spironolactone and poly(vinylpyrrolidone-co-vinyl acetate). The same apparatus was used to produce,…
Understanding the role of colon-specific microparticles based on retrograded starch/pectin in the…
The encapsulation of nanoparticles within microparticles designed for specific delivery to the colon is a relevant strategy to avoid premature degradation or release of nanoparticles during their passage through the stomach and upper…
A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was…
Process optimization of twin-screw melt granulation of fenofibrate using design of experiment (DoE)
The purpose of this study was to optimize the melt granulation process of fenofibrate using twin-screw granulator. Initial screening was performed to select the excipients required for melt granulation process. A 3 × 3 factorial design was…
Engineering precision nanoparticles for drug delivery
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers — systemic,…
Lipid-based formulations: A winning strategy for oral bioavailability enhancement
The key to lipid-based formulation success relies in the right selection of the lipid excipients to develop an optimized formulation, enabling solubilization of the drug throughout the digestion process for enhancement of oral…
Development of pH-sensitive vaginal films based on methacrylate copolymers for topical HIV-1…
Interest is growing in “smart” vaginal microbicides as a strategy to protect women from sexual transmission of human immunodeficiency virus (HIV). The concept is based on the development of products featuring low drug release in acidic…
A novel approach to determine the granule density of milled ribbons using multi-stage air…
Determination of the granule density as a critical quality attribute during roller compaction/dry granulation provides an important parameter for further successful processing of the compacted materials. In this study, a novel approach was…
PMC Isochem To accelerate Polyamino acids Business as part of ISODEL® Drug Delivery offer, a unique…
Press release - Contact: Patti Griggs 856-533-1870
PMC Isochem announces today that it is accelerating the strategic development and manufacture of polyamino acids (PAA) as functional excipients used in complex formulations and drug…
Stereolithography (SLA) 3D printing of a bladder device for intravesical drug delivery
Intravesical instillation therapy is an alternative approach to oral medications for the treatment of severe bladder diseases, offering high drug concentrations at the site of action while minimising systemic side effects. However,…
3D Printing in Pharma with Lactose
3D printing brings a whole new dimension to Lactose
Are you ready for the future? 3D Powder bed printing enables to transform the pharmaceutical industry for the better. However only limited expertise on excipient usage in powder bed…
Development of Porous Polyurethane Implants Manufactured via Hot-Melt Extrusion
Implantable drug delivery systems (IDDSs) offer good patient compliance and allow the controlled delivery of drugs over prolonged times. However, their application is limited due to the scarce material selection and the limited…
Pharmaceutical applications of aqueous scaled-up electrospinning
Thesis findings
A solid formulation of a model biopharmaceutical drug (β-galactosidase) was developed and produced by high-speed electrospinning for the first time. A fully aqueous polymeric solution was successfully electrospun with a 30…
Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica…
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed as an immediate-release tablet with a high drug load (e.g., 40% w/w) to produce heightened maintenance of drug…
Cannabis Compliance Testing: Safety vs. Quality
In this Q&A, we hear from Dr. Markus Roggen and Tomas Skrinskas as they provide their take on the challenges facing the industry’s compliance testing standards as well as some opportunities in advanced analytical chemistry.
What are…
Permeation and Absorption of Ethanol/Water Mixture through Ethylcellulose Film
Ethylcellulose (EC) is water-insoluble, rate-controlling polymer which has been widely used as coatings of oral solid dosage forms, excipients for amorphous solid dispersions of active pharmaceutical ingredients (APIs), and films for buccal…
Review of sensing technologies for measuring powder density variations during pharmaceutical solid…
Oral solid dosage forms, the most widely used pharmaceutical products, are typically manufactured through a series of processes that transform a blend of drug and excipient particles into a densified product with consistent quality…
The Role of Extracellular Vesicles in the Skin and Their Interactions with Nanoparticles
Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and…