Lyotropic liquid crystal emulsions of LAVR-289: Influence of internal mesophase structure on cytotoxicity and in-vitro antiviral activity
Emerging and reemerging viruses pose significant public health threats, underscoring the urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside phosphonates (ANP) composed of a 4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl phosphonic acid skeleton (O-DAPy nucleobase) has shown promise. Among these, LAVR-289…
Friday’s Top 5 by pharmaexcipients
Story of the week
ExciPerience
Safe the date March 9 & 10, 2021 for the first virtual event by pharmaexcipients around excipients. More to come soon!
Top 5 posts of the week
#1 The use of natural phospholipids as pharmaceutical…
Lipid and Biosurfactant Based Core–Shell-Type Nanocapsules Having High Drug Loading of Paclitaxel…
The current investigation illustrates high drug loading of Paclitaxel (PTX) in lipid- and biosurfactant-based core–shell-type nanocapsules for improving therapeutic potential and reducing toxicity of PTX. The nanocapsules were prepared…
Poloxamine/D-α-Tocopheryl polyethylene glycol succinate (TPGS) mixed micelles and gels: Morphology,…
The combination of polymeric surfactants with different features into mixed micelles give access to properties that may be superior to the single-component micelles. In this work, we investigated synergistic effects in mixtures of…
Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process
Purpose
Drug X is high solubility, high permeability BCS/DCS I small molecule drug.
High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible…
Handbook of Pharmaceutical Excipients – New Edition – Out Now with a special offer!
Order your copy today and save 10%*
The Handbook of Pharmaceutical Excipients is internationally recognised as the world’s most authoritative source of information on pharmaceutical excipients. It provides you with a one stop resource…
Measurement and quantification of caking in excipients and food products with emphasis on the…
Whilst caking occurs via several different mechanisms, absorption and migration of moisture is frequently the most dominant mechanism within the food and pharmaceutical industry. Fully understanding the propensity to cake is important for…
An Investigation of the Influence of PEG 400 and PEG-6-Caprylic/Capric Glycerides on Dermal Delivery…
Polyethylene glycols (PEGs) and PEG derivatives are used in a range of cosmetic and pharmaceutical products. However, few studies have investigated the influence of PEGs and their related derivatives on skin permeation, especially when…
Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam
The objectives of this study are the development and evaluation of modified release multi-particulate drug delivery systems containing a BCS class II drug (meloxicam), formulated as polymer-coated pellets. Inert seeds containing…
A Tool For Preformulation Assessment Of Excipients
Written by Dr Steve Robinson | 01-Dec-2020
Excipients from different batches or vendors may be variable in quality and it is often necessary to perform pre-formulation assessment for each batch of excipient received. In some cases,…
Evaluation of different pre-processing methods of X-ray micro computed tomography images
Adequate images of real tablets provide the possibility to validate in silico software tools like F-CAD. The goal of this work was to evaluate the influence of different pre-processing methods of X-ray micro-computed tomography images of 12…
Enhancing the Low Oral Bioavailability of Sulpiride via Fast Orally Disintegrating Tablets:…
Sulpiride (SUL) is a dopamine D2-receptor antagonist used for management of GIT disturbance and it has anti-psychotic activities based on the administered dose. SUL undergoes P-glycoprotein efflux, which lead to poor bioavailability and…
Development of integrated continuous pharmaceutical technologies
Thesis findings
1. Acetylsalicylic acid (ASA) was synthesized in continuous flow reactors for the first time. Design of experiment studies were conducted in order to optimize the two synthetic steps: i.e. the acetylation of salicylic…
3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment
In this study Fusion Deposition Modelling (FDM) was employed to design and fabricate a bilayer tablet consisting of isoniazid (INZ) and rifampicin (RFC) for the treatment of tuberculosis. INZ was formulated in hydroxypropyl cellulose (HPC)…
ExciPerience – The new virtual event experience for pharmaceutical excipients
Exciperience is the new virtual event around every aspect of pharmaceutical excipients. By Pharma Excipients – the main digital source for information and transaction of pharmaceutical excipients for many years now. Following our mission to…
Lipid Composition Effect on Liposome Properties: Role of Cholesterol
December 3rd, 2020 - Written by Natalia Sannikova, R&D Manager, Ascension Sciences
Introduction
Solubility of hydrophobic drugs such as cannabinoids can be greatly improved by liposome encapsulation. Lipid composition can be adjusted…
The use of natural phospholipids as pharmaceutical excipients
Phospholipids are used in many types of formulations, such as fat emulsions, mixed micelles, suspensions, and liposomal preparations for any administration route . Phospholipids are surface-active comprising a polar headgroup and a…
Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical…
The complexity of hard‐to‐treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve…
Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal…
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were…
Lipids in multi resistant bacteria
Article by Henri Deda - Communications Officer at Lipotype
The full article was first published on https://www.lipotype.com, and you can read the original article here
Summary
• Pseudomonas aeruginosa is a multi resistant bacterium
•…
Evaluation on Biorelevant Dissolution Behavior of Propranolol HCl Encapsulated in Various Capsules
Two-piece hard capsules continuously serve as widely used oral drug and dietary supplement dosage forms. Hard gelatin capsules are used in 20% of all oral dosage forms but have numerous shortcomings especially with potential crosslinking…
Controlled Delivery of Bile Acids to the Colon
Bile acids, such as chenodeoxycholic acid, play an important role in digestion but are also involved in intestinal motility, fluid homeostasis, and humoral activity. Colonic delivery of sodium chenodeoxycholate (CDC) has demonstrated…
Rheological characterization of polymeric solutions used in spray drying process
The present works contributes with a rheological characterization of the most commonly used polymers and solvents to formulate amorphous solid dispersions by means of spray drying process: copovidone, hydroxypropyl methylcellulose (HPMC),…
Long-Acting Drug Delivery: Injections, Implants, and Combination Products
Combination products and drug delivery devices aid in patient compliance and a movement toward point-of-care at home. In this article, Nick DiFranco, Market Manager – Long-Acting Drug Delivery and Combination Products, discusses trends in…
Directly compressible hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing
This work was undertaken to evaluate a novel hydroxypropyl methylcellulose excipient used in the manufacture of hydrophilic matrix tablets for oral controlled release. This material was coprocessed with a small amount of silicon dioxide to…
The efficient development of a sildenafil orally disintegrating tablet using a material sparing and…
The purpose of this work is to develop an orally disintegrating tablet (ODT) of sildenafil (SIL) using a materials sparing and expedited development approach, enabled by the materials science tetrahedron principle and predictive…
Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide)…
Supramolecular micelles are of particular interest in cancer therapy, owing to their capability to enable the on-demand drug release in tumor microenvironments. Nano platforms of supramolecular micelles can be facilely achieved from …
Melt Milling as Manufacturing Method for Solid Crystalline Suspensions
Production of submicron particles (0.1-1 µm) has been identified by the pharmaceutical industry as a key technology to enhance the bioavailability of poorly water-soluble drugs. However, nanosuspensions derived from commonly applied wet…
3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of…
The aim of this study was to fabricate novel self-supporting tacrolimus suppositories using semisolid extrusion 3-dimensional printing (3DP) and to investigate their efficacy in an experimental model of inflammatory bowel disease. Blends of…
Development of a nanoparticle delivery system based on zein/polysaccharide complexes
Zein, an alcohol‐soluble protein in corn, can self‐assemble into spherical nanoparticles, which makes it an ideal carrier material for the encapsulation of hydrophobic bioactive molecules. However, zein nanoparticles easily aggregate in…
Characterization of Sulfobutyl Ether Betacyclodextrin Binary and Ternary Inclusion Complexes of…
Background: Poor solubility and dissolution of drugs are major hindering factors in the development of their
oral dosage forms with acceptable bioavailability. Of the various approaches, employing amorphous form of
drugs is frequently…
Thiolated and PEGylated silica nanoparticle delivery to hair follicles
Targeting drug delivery to hair follicles is valuable to treat conditions such as alopecia’s and acne, and this shunt route may also allow drug delivery to deeper skin layers and the systemic circulation by avoiding the intact stratum…
Making tablet coating faster, easier, safer and consistent by switching from in-house coating to…
Tablet Coating Webinar by Kerry - December 17, 2020
Big pharma manufacturers are moving away from traditional in-house coating to a more efficient practice of using aqueous based ready-mix coating systems. Innovators are starting to…
Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2
Objective(s): Liqui-Mass technology has shown promising advantages in terms of commercial production and formulation manipulation. This study attempts to further explore the potential of enhanced drug release of effervescent Liqui-Pellet by…
Oral preparations with tunable dissolution behavior based on selective laser sintering technique
Selective laser sintering (SLS) sinters a powder layer by layer with a laser beam to prepare 3D printlets, which are widely used in the field of tissue engineering and personalized implants. To promote the SLS printing of oral solid…