PVA-based formulations as a design-technology platform for orally disintegrating film matrices
Abstract
In the majority of pharmaceutical applications, polymers are employed extensively in a diverse range of pharmaceutical products, serving as indispensable components of contemporary solid oral dosage forms. A comprehensive understanding of the properties of polymers and selection the appropriate methods of characterization is essential…
Comparing Different Moisture Protective Instant Release Coatings for Solid Oral Dosage Forms
Introduction: Drug stability and shelf life are main targets of current pharmaceutical development as many active ingredients are highly moisture sensitive. Instead of using impermeable and expensive packaging materials it appears advisable…
Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology
Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with interesting physicochemical and thermochemical…
Advanced design and development of nanoparticle/microparticle dual-drug combination lactose…
Lactose is the only FDA-approved carrier for dry powder inhaler (DPI) formulations in the US. Lactose carrier-based DPI products are contraindicated in patients with a known lactose allergy. Hence, inhaler formulations without lactose will…
Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of…
In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable…
Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative…
The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated…
Supersaturated silica-lipid hybrids have previously demonstrated improved in vitro solubilisation and in vivo oral bioavailability of poorly water-soluble drugs, however were only fabricated using a single lipid (LFCS type I formulations)…
Troubleshooting Guide – Top 10 Coating Errors And How To Avoid Them
10 Errors that can occur during the coating process and how to avoid them
Many parameters must be considered before and during the coating process. Sometimes it is necessary to adjust parameters to get the best possible result.
See…
Friday’s Top 5 by pharmaexcipients
Top News of the week
New vegetarian softgel system by Roquette
Roquette launched LYCAGEL™ Market-first plant-based softgel system provides a strong alternative to gelatin for nutraceutical and pharmaceutical manufacturers and marketers…
SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs
Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they attract the attention of researchers in order to confront the challenge of poor water-solubility of orally given drugs. Within recent years, SEDDS were…
Hemp in tablets or capsules – Excipients for CBD
Hemp products are mostly sold in liquid form. Companies who are trying to change this and offer solid dose products have to face different challenges.
The challenges depend on their choice of solid dosage form (tablets or capsules),…
Hot Topic Day “3D printing in Pharmaceutics” on November 27th 2020
3D Printing has become a “Hot Topic” in Pharmaceutics:
The versatility of this novel production technique offers a large range of advantages and will likely enable substantially improved medications in the future. Personalized medicine…
Ligand’s Captisol Technology Plays Key Role In The Manufacture Of Gilead’s Veklury, The…
SAN DIEGO--(BUSINESS WIRE) -- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) today highlighted the company’s role in the manufacturing of Veklury® (remdesivir), Gilead Sciences’ antiviral drug for the treatment of patients with COVID-19…
LYCAGEL™ – Roquette’s Innovative Plant-Based Solution Unlocks Possibilities for Veggie Softgel…
Market-first plant-based softgel system provides a strong alternative to gelatin for nutraceutical and pharmaceutical manufacturers and marketers of softgel products
GENEVA, Illinois. (November 18, 2020) - Roquette, a global leader in…
Film-sugar-coating in a short time – with IsuPolish® FSC
Isupolish® FSC is a unique, dry milled, homogeneous blend of hypromellose, Isomalt or sucrose, pigments and additional excipients. Compared to a traditional sugar-coating process this product assists you to speed up the production process.…
I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets
3D printing (3DP) in the pharmaceutical field is a disruptive technology that allows the preparation of personalised medicines at the point of dispensing. The paediatric population presents a variety of pharmaceutical formulation challenges…
Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug…
Amorphous solid dispersion (ASD) has become an attractive strategy to enhance solubility and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are commonly incorporated into tablets. Disintegration and…
Smart liquids for oral controlled drug release: An overview of alginate and non-alginate based…
Sustaining and controlling the rate of drug release is essential in pharmaceutical technology. It can reduce the number of units administered by the patient with subsequent improvement in patient compliance. These technologies can allow…
Pharmaceutical Co-crystals, Salts, and Co-amorphous Systems: A novel opportunity of hot-melt…
Enhancing the solubility of active drug ingredients is a major challenge faced by scientists and researchers. Different approaches have been explored for the enhancement of solubility and physicochemical properties of drugs, without…
The progress on sulfhydryl modified polymers with regard to synthesis, characterization and…
The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients…
Evaluation of multifunctional magnesium aluminosilicate materials as novel family of glidants in…
The work was aimed at evaluating the efficiency of multifunctional magnesium aluminosilicate materials (MAS) as a novel glidant in solid dosage forms. MAS are known for their very low cohesive interactions and their utilization could avoid…
Multiparticulates Part 4a: Functional coating applications – The Basics
This is the 4th Webinar on Multiparticulates in our series of "Multiparticulates - Modern oral drug products for our society". In this webinar Norbert Pöllinger will inform you on the basics of functional coating applications.…
Fabrication of large pore mesoporous silica microspheres by salt-assisted spray-drying method for…
Large-pore mesoporous silica (LPMS) microspheres with tunable pore size have received intensive interest in the field of drug delivery due to their high storage capacity and fast delivery rate of drugs. In this work, a facile salt-assisted…
Insights in the rheological properties of PLGA-PEG-PLGA aqueous dispersions: structural properties…
PLGA-PEG-PLGA are copolymers, able to form temperature-dependent hydrogels or sol dispersions at selective conditions. A general overview about the rheological characterization of their aqueous dispersions, focusing how the structural…
Towards better understanding of the influence of process parameters in roll compaction/ dry…
A key quality attribute for solid oral dosage forms is their hardness and ability to withstand breaking or grinding. If the product is to be manufactured continuously, it can be of interest to monitor the hardness of the material at…
Paclitaxel-Loaded Colloidal Silica and TPGS-Based Solid Self-Emulsifying System Interferes Akt/mTOR…
A solid self-emulsifying drug delivery system (SEDDS) of paclitaxel (PTX) was developed that could enhance its oral bioavailability and neutralize other niggles associated with conventional delivery systems of PTX. TPGS-centered SEDDS…
Pharmaceutical Material Engineering: Evaluation of Carvedilol Polymorphs II and III Surface by…
Solid forms can influence the dissolution, stability, and processability of active pharmaceutical ingredients. However, besides the internal arrangement, crystal habit studies are important, since the exposure of different crystal faces…
Nanocarriers Mediated Cutaneous Drug Delivery
The cutaneous drug delivery represents an attractive option for the management of skin diseases. However, the skin has a very complex morphological structure, although the skin barrier is disrupted in some of dermatological diseases.…
Powder Characterisation for Formulators
The goals of formulation
Accelerating product development through formulation into successful manufacture and on to the marketplace, is an important goal for the pharmaceutical industry. Optimising the formulation process and more…
The enhancement of the aqueous solubility of Albendazole employing polymeric amorphous solid…
PURPOSE
Poor aqueous solubility is a significant issue in the current pharmaceutical industry with approximately 90% of new chemical entities in the development pipeline characterised as poorly watersoluble.
Amongst various means to…
Evaluation of dissolution techniques for orally disintegrating mini-tablets
Mini-tablets are suitable for paediatric as well as geriatric use since they may provide flexible and accurate dosing and administration. Due to the minute tablet size, there is a need for new standardized quality evaluation procedures and…
Design of a pH-responsive oral gel formulation based on the matrix systems of gelatin/hydroxypropyl…
Extensive efforts have been directed toward developing novel easily digested formulations with desirable controlled-release properties. The present study sought to develop pH-responsive oral gel formulations using combinations of gelatin…
Comparison of the In Vitro and Ex Vivo Permeation of Existing Topical Formulations Used in the…
Rapamycin has been used topically to treat facial angiofibromas associated with tuberous sclerosis for more than a decade. In the absence of a commercial form, a large number of formulations have been clinically tested. However, given the…
Data-smart machine learning methods for predicting composition-dependent Young’s modulus of…
The ability to predict mechanical properties of compacted powder blends of Active Pharmaceutical Ingredients (API) and excipients solely from component properties can reduce the amount of ‘trial-and-error’ involved in formulation design.…
Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
PURPOSE
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance.
One promising strategy to formulate such dosage forms…