PVA-based formulations as a design-technology platform for orally disintegrating film matrices
Abstract
In the majority of pharmaceutical applications, polymers are employed extensively in a diverse range of pharmaceutical products, serving as indispensable components of contemporary solid oral dosage forms. A comprehensive understanding of the properties of polymers and selection the appropriate methods of characterization is essential…
3D-printing of lopinavir printlets by selective laser sintering and quantification of crystalline…
The objectives of this study were to develop and characterize amorphous lopinavir (LPV) printlets and to the quantify crystalline fraction of LPV in the printlets by X-ray powder diffraction (XRPD)-chemometric models. Amorphous printlets…
Effect of intra- and extragranular addition of highly porous tribasic calcium phosphate on…
Immediate release, compositionally proportional formulations of acyclovir comprising porous tribasic calcium phosphate were developed and compared with commercial tablets. Comparison of the dissolution behavior was carried out using a…
Polymers in Rectal Drug Delivery
Drug delivery through the mucosal membranes has been exploited to overcome the disadvantages associated with more popular routes such as oral and intravenous.
Rectal drug delivery, by virtue of high permeability, direct access to…
Contract for innovative delivery system for COVID-19 vaccine
Press Release Croda
This announcement contains inside information for the purposes of Article 7 of the Market Abuse Regulation (EU) No 596/2014. The person responsible for making this announcement is David Bishop, Director of Investor…
Residence time distribution modelling and in line monitoring of drug concentration in a tablet press…
The presence of a ‘significant dead zone’ in any continuous manufacturing equipment may affect the product quality and need to be investigated systematically. Dead zone will affect the residence time distribution (RTD) of continuous…
Mucoadhesive wafers for buccal delivery of probiotic bacteria: Mechanical properties and enumeration
The development of probiotic formulations has attracted great attention of researchers and industrial community. Their beneficial effects have been demonstrated in human health, and in buccal cavity including prevention of gingivitis,…
A novel amorphous solid dispersion based on drug–polymer complexation
Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP complexation on in…
W. R. Grace & Co. Site In Baltimore, Maryland, USA Receives EXCiPACT GMP Certification As…
EXCiPACT asbl is pleased to announce that the W. R. Grace site in Baltimore, Maryland, USA has recently been awarded an EXCiPACT GMP Certificate from SGS, one of EXCIPACT’s internationally recognised Certification Bodies.
The Certificate…
Applications of Polymers in Parenteral Drug Delivery
Parenteral drug delivery plays a very vital role in pharmacotherapy of various acute and critical illnesses. Injectables have been preferred formulations over oral and topicals especially in case where rapid effects of drugs are required or…
Topical Delivery of Cannabinoids
Providing texture and stability
A short video to explain how Gattefossé all-in-one emulsifiers help simplify topical formulations and enable to obtain a wide range of sensorial textures
Tefose® 63: widely used oil-in-water…
Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing…
Starch is a commonly used excipient in the pharmaceutical industry. However, information on the effect of the moisture scavenging properties of starch to protect moisture-sensitive drugs is limited. The interaction between starch and…
Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use
In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane.
AIM: The…
Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels
Purpose
Delivering ophthalmic drugs to the target tissues in eye is challenging due to transport barriers. Rapid tear clearance of the drug instilled as eye drops to treat anterior segment diseases results in a low ocular permeability of…
Effect of Carrier Type and Tween® 80 Concentration on the Silymarin Release from the Solid…
The following poster was presented first at AAPS PharmSci 360 in October 2020. We had the chance to get a short introduction from the creator Valentyn Mohylyuk as a audio file.
PURPOSE
Silybin (the active component of Silymarin)…
Tailoring lipid nanoconstructs for the oral delivery of Paliperidone
The present research work involves Quality by Design (QbD)-based fabrication of lipid nanoconstructs (LNC) of paliperidone (PPD) bearing superior biopharmaceutical attributes.
Highlights
Lipid nanoconstructs (LNC) is a potential carrier…
Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising…
An investigation into applicability of different compression behaviour assessment approaches for…
Increasing expectations to understand material properties and process parameters impact on drug product performance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during compression. Several…
Applications of Polymers in Colon Drug Delivery
Colon-targeted drug delivery possesses numerous advantages in pharmaceutical delivery systems. Both local and systemic deliveries of active ingredients are possible with help of polymers in colon-targeted delivery.
Targeting colon can be…
Optimization of residence time distribution in RCDG and an assessment of its applicability in…
Knowledge of residence time is a critical aspect in developing control and material diversion strategies for continuous manufacturing processes in pharmaceutical manufacturing. Dry granulation is a promising continuous granulation technique…
Friday’s Top 5 by pharmaexcipients
What happened this week?
The interview Dr. Christian Nowak on Meggle's new product Reta M® was one of our highlights during the last weeks. Reta M® is the first lactose-free Meggle excipient product for modified release but read more…
Polymers Used in Peyer’s Patch Targeting
Peyer’s Patches (PPs) consist of transmucosal clusters of lymphoid follicles overlaid with a specialized lymphoepithelium and play an essential role in the initiation of mucosal immune responses in the gut. Regardless of extensive…
Colouring Orally Dispersible Tablets
Delivering active ingredients via orally dispersible tablets (ODTs) is a recent trend in the pharmaceutical industry. Due to the easy and fast application, patient’s compliance is high for this kind of dosage form. To ensure a fast drug…
The relevance of granule fragmentation on reduced tabletability of granules from ductile or brittle…
Roll compaction/dry granulation often results in loss of tabletability. The two main hypotheses for this are granule hardening and granule size enlargement. The aim of this study was to investigate the effect of granule size, roll…
Effect of Disintegrants on Prolongation of Tablet Disintegration Induced by Immersion in Xanthan…
In clinical practice, a thickening solution is frequently used to allow easy swallowing of tablets by patients suffering from dysphagia. This study investigated the effect of the thickening solution on tablet disintegration. Model tablets…
Impact of Magnesium Stearate Content: Modeling of Drug Degradation Using a Modified Arrhenius…
To accelerate drug development, the pharmaceutical industry is working to shorten and improve studies on stability. The Accelerated Stability Assessment Program (ASAP) incorporating the humidity-corrected Arrhenius equation as an…
Polymeric Inserts Containing Eudragit® L100 Nanoparticle for Improved Ocular Delivery of…
Polymeric inserts containing azithromycin-loaded Eudragit® L100 nanoparticles were developed to sustain the drug release and enhance its ocular performance. The solvent diffusion technique was employed to prepare nanoparticles. The…
Meggle Reta M® – The Interview
MEGGLE released the new excipient Reta M® at October 13. Pharma Excipients used the chance to do an interview with the responsible product manager, Dr. Christian Nowak, to learn more about Reta M®. It is the first…
Rettenmaier Natural Fiber Manufacturing (Changzhou) Site In Jiangsu Province In Pr China Receives…
EXCiPACT Press Release, Brussels, 04 November 2020
EXCiPACT asbl is pleased to announce that the Rettenmaier Natural Fiber Manufacturing (Changzhou) site in Jiangsu Province, PR China has recently been awarded an EXCiPACT GMP…
Polymers in Transdermal Drug Delivery
Current researches in the branch of polymer-mediated transdermal drug delivery systems (DDSs) are one of the most promising approaches as it bypasses the hepatic first-pass metabolism and improves patient compliance. The main barrier to…
A Novel Method for Preparing Stabilized Amorphous Solid Dispersion Drug Formulations Using Acoustic…
A diverse set of drug and polymer combinations have been effectively evaluated utilizing a newly developed method called acoustic fusion to form amorphous solid dispersions (ASD) on the mg-scale, indicating that this approach is a general…
A Comprehensive Review on Pharmaceutical Film Coating: Past, Present, and Future
Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage…
Characterization Requirements for New Excipients
Novel excipients can play a major role in innovation processes, but physicochemical properties, performance and safety must be adequately demonstrated. Characterization requirements for novel excipients are discussed and illustrated with…
Applications of Polymers in Small Intestinal Drug Delivery
Delivery to small intestine is the most sought and favorable approach among the therapeutics delivered by oral route. The significant importance of preferential delivery of drugs to the intestine is the availability of large surface area,…
Evonik launches EUDRAGIT® ready-to-use powder premix
Evonik launches EUDRAGIT® ready-to-use powder premix to improve processing, appearance and swallowability of oral drug products with an immediate release profile.
EUDRAGIT® IR ReadyMix White requires half the processing time of HPMC or…