Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Cushion-coated pellets for tableting without external excipients
Multiple-unit dosage forms prepared by compacting pellets offer important manufacturing and compliance advantages over pellet-filled capsules. However, compaction may negatively affect the release control mechanism of pellets, and subunits…
Alternative For Prohibited Food Additive TiO2
The discussion about the excipient titanium dioxide in the European food industry is already several years old. TiO2 was banned from food products in the EU and other countries since 2022 as being maybe carcinogenic . This even had…
Lactalis – See their family of pharmaceutical grade lactose monohydrate
Benefiting from the experience and technology of decades, Lactalis was able to enter
the excipients’ market with its pharmaceutical lactose products in the forth quarter of 2023.
The Lactalpha range is composed of milled and sieved…
Tailoring drug release in bilayer tablets through droplet deposition modeling and injection molding
Abstract
This study explores the innovative production of personalized bilayer tablets, integrating two advanced manufacturing techniques: Droplet Deposition Modeling (DDM) and Injection Molding (IM). Unlike traditional methods limited to…
PhytoSquene® – Your plant-derived squalene for parenteral applications
PRESERVING BIODIVERSITY AND ENSURING SAFETY WITH NON-ANIMAL-DERIVED SQUALENE
PhytoSquene® is our non-animal-derived squalene that can be used in vaccines and other pharmaceutical applications. This alternative to animal-derived…
Quality by design driven systematic development of nanoemulgel of clobetasol-17-propionate for…
Abstract
Nanoemulgels require two step formulation, the first one being formulation of nanoemulsion followed by the incorporation of nanoemulsion within a gel matrix. The current investigation aimed to formulate a Clobetasol-17-propionate…
d-α-tocopheryl polyethylene glycol 1000 succinate surface scaffold polysarcosine based polymeric…
In this study, Enzalutamide (ENZ) loaded Poly Lactic-co-Glycolic Acid (PLGA) nanoparticles coated with polysarcosine and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared using a three-step modified nanoprecipitation…
Parteck® LM Excipient System – Reduce complexity in your formulation and optimize results
Discover our, Merck, new Parteck® LM Excipient System: This exceptional product offers excellent flow properties, ensuring reliable dosing in both batch and continuous processes. With its consistent dosing and robust, constant mixing times,…
HME as Advanced Approach for Development of Solid Self Emulsifying Drug Delivery System
The pharmaceutical industry is paying more and more attention to hot-melt extrusion (HME), but this technology's promise for creating solid self-emulsifying drug delivery systems (S-SMEDDS) has not yet been fully realized. The numerous…
Research on classification of natural plant products and critical factors affecting tablet…
Abstract
The complex physical properties of natural plant products (NPPs) greatly influence the disintegration of NPP tablets, and the evaluation of their disintegration properties is generally overlooked. To solve this problem, the study…
Simultaneous photo-induced polymerization and surface modification by microfluidic spinning to…
Functionalized polymer fibers were prepared by microfluidic spinning involving simultaneous photopolymerization and surface modification. A capillary-based microfluidic device was used with two miscible coaxially co-flowing phases to afford…
Self-Emulsifying Drug Delivery System for Enhanced Oral Delivery of Tenofovir: Formulation,…
Tenofovir (TNF) is a common component of many antiretroviral therapy regimens, but it is associated with poor membrane permeability and low oral bioavailability. To improve its oral bioavailability and membrane permeability, a…
In vitro and in vivo toxicity of thiolated and PEGylated organosilica nanoparticles
This study comprises the comprehensive toxicological assessment of thiolated organosilica nanoparticles (NPs) synthesised from 3-mercaptopropyltrimethoxysilane (MPTS). We investigated the influence of three different types of nanoparticles…
Influence of refilling on dosing accuracy of loss-in-weight powder feeders in continuous…
Abstract
Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high…
Tableting of coated multiparticulates: Influences of punch face configurations
Abstract
The influences of the punch face design on multi-unit pellet system (MUPS) tablets were investigated. Drug-loaded pellets coated with sustained release polymer based on ethylcellulose or acrylic were compacted into MUPS tablets.…
Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor…
Abstract
Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption. This article presents a strategy to…
Enhancing solubility and stability of piperine using β-cyclodextrin derivatives: computational and…
Piperine (PP), a natural alkaloid found in black pepper, possesses significant bioactivities. However, its use in pharmaceutical applications is hindered by low water solubility and susceptibility to UV light degradation. To overcome these…
High purity excipients for parenteral drug delivery
Parenteral formulation frequently faces limitations associated with drug stability and poor solubility. Drug compatibility and the minimum concentration of drug required to produce the targeted pharmacological effect are key to excipient…
Multi-particulate formulations: the power of many
After assessing the various routes of drug administration, oral delivery stands out as the safest and, as a result, the most universally accepted among patients. Single-unit dosage forms, including tablets followed by capsules, have been…
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with…
The aim of this work was to study the possibility to use SepitrapTM as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancement of poorly water-soluble drugs.…
Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia
Abstract
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have…
De novo development of small cyclic peptides that are orally bioavailable
Abstract
Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied…
Rheology of amino-functionalized graphene oxide suspensions in hydrogels
This work investigates the effects of amino-functionalized graphene oxide (AFGO) suspensions on the rheological behavior of Carbopol® hydrogels at pHs 5, 7, and 9. The AFGO concentration and media pH were evaluated and related to the…
A Comprehensive Review of Disintegrants: Backbone of disintegration
Abstract
Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then…
Transdermal delivery and exploration of preclinical anti-rheumatoid efficacy of pirfenidone embedded…
To avoid adverse effects associated with non-site-specific delivery and target major signaling pathways responsible for the inflammation in rheumatoid arthritis, the current study aims to formulate and evaluate the transdermally…
Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel…
In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3, 10:4, and…
Sticking Detection by Repeated Compactions on a Single Tablet
“Sticking” during tablet manufacture is the term used to describe the accumulation of adhered tablet material on the punch over the course of several compaction cycles. The occurrence of sticking can affect tablet weight, image, and…
Mucoadhesive Vaginal Tablets Containing Metronidazole: Screening of Optimal Natural Polymer in the…
(1) Background: The study aimed to compare the impact of various natural polymers–sodium alginate, acacia gum, carrageenan, guar gum, xanthan gum, and tragacanth on the formulation and the physical properties of mucoadhesive vaginal tablets…
Inhaled dry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency…
Comparison of Different Sorbitol Sorbitan Solutions as Gelatin Plasticizer
INTRODUCTION
Soft capsules are a popular dosage form for dispensing active pharmaceutical or nutraceutical materials. The shell material is frequently composed of gelatin, softened with considerable amount of plasticizer. They are…
Mechanistic Insight in Permeability through Different Membranes in the Presence of Pharmaceutical…
The present study reports the effects of two pharmaceutical excipients of differing natures—non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β-CD)—on the permeation of the model compound,…
Effect of Talc and Vitamin E TPGS on Manufacturability, Stability and Release Properties of…
This study was focused on one particular case of hot-melt coating with trilaurin – a solid medium-chain monoacid triglyceride. The challenge of using trilaurin as coating agent in melting-based processes is linked to its relatively low…
W/O/W microemulsions for nasal delivery of hydrophilic compounds: a preliminary study
The administration of hydrophilic therapeutics has always been a great challenge because of their low bioavailability after administration. For this purpose, W/O/W microemulsion resulted to be a potential successful strategy for the…
Design of High-Payload Ascorbyl Palmitate Nanosuspensions for Enhanced Skin Delivery
A high-payload ascorbyl palmitate (AP) nanosuspension (NS) was designed to improve skin delivery following topical application. The AP-loaded NS systems were prepared using the bead-milling technique, and softly thickened into NS-loaded gel…