PVA-based formulations as a design-technology platform for orally disintegrating film matrices
Abstract
In the majority of pharmaceutical applications, polymers are employed extensively in a diverse range of pharmaceutical products, serving as indispensable components of contemporary solid oral dosage forms. A comprehensive understanding of the properties of polymers and selection the appropriate methods of characterization is essential…
De-risking excipient particle size distribution variability with automated robust mixing:…
Particle size distribution (PSD) variability in excipients affects mixing. In response, manufacturers rely on raw material control and rigidly defined process parameters to achieve quality. However, this status quo is costly; and diverges…
Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications
Purpose: A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare…
Application of Dominance-Based Rough Set Approach for Optimization of Pellets Tableting Process
Multiple-unit pellet systems (MUPS) oer many advantages over conventional solid dosage forms both for the manufacturers and patients. Coated pellets can be efficiently compressed into MUPS in classic tableting process and enable controlled…
Multiparticulates For Paediatric Oral Drug Delivery – Glatt Pharmaceutical Services
As the demand for pediatric dosage forms continues to increase across the industry, there can be formulation challenges for this patient population. Pediatric patients may require different dosage forms depending on age ranges, and patient…
How to Solve Drug Delivery Challenges of Cannabinoids Using Nanotechnology
Liposomes, nanoemulsions and polymeric nanoparticles have all shown promise in improving the therapeutic benefits of cannabinoids, but the full potential of these therapies has not yet been unlocked. Nanotechnology for active pharmaceutical…
Liquisolid tablets – A rationale for formulation and process design
A significant proportion of new API’s in development are poorly soluble and require alternative formulation approaches to achieve adequate oral bioavailability. One option is to develop lipid-based formulations. Lipid formulations are…
Electrospraying as a novel method of particle engineering for drug delivery vehicles
Encapsulation technologies can be used to preserve therapeutic and bioactive compounds from harsh conditions (e.g., light, moisture, and oxygen) and biological destruction (enzymes, metabolism, and phagocytosis). Encapsulation involves the…
Improved skin-permeated diclofenac-loaded lyotropic liquid crystal nanoparticles: QbD-driven…
The purpose of the present study was to optimise diclofenac diethylamine-loaded liquid crystal nanoparticles (LCNPs) using the principles of quality by design. Based on risk assessment, the effect of various formulation variables on the…
Top 1000 Pharma Companies in 2020
As the world looks towards the pharmaceutical industry in the hope of a vaccine that could put an end to the pandemic caused by the novel coronavirus, investment bank Torreya has brought out an interesting report on the top 1000 global…
Investigation into powder tribo–charging of pharmaceuticals. Part II: sensitivity to relative…
Environmental conditions can have a profound impact on the bulk behaviour of pharmaceutical powders, including their tribo–charging tendency. Typically, high relative humidity (RH) has been associated to a reduction in the electrostatic…
Applications of Polymers in Gastric Drug Delivery
Gastroretentive drug delivery system (GRDDS) is one of the key research areas in focus due to its ability to improve therapy by increasing residence time of drugs having narrow absorption window, demand residence in stomach due to their…
Applications of Polymers in Buccal Drug Delivery
Over the last decades, systemic drug delivery through oral mucosa has received a great deal of attention. Actually buccal mucosa is an attractive route due to its ease of accessibility, rapid efficacy, smooth and relatively immobile…
Investigation into powder tribo-charging of pharmaceuticals. Part I: process-induced charge via…
Powder feeding is a crucial unit operation in continuous manufacturing (CM) of pharmaceutical products. Twin–screw feeders are typically employed to ensure the accurate mass flow of pharmaceutical materials throughout the production…
Stabilization of amorphous drugs – are crystalline inorganic excipients a way forward?
Physical instability arguably is the major challenge in using neat amorphous active pharmaceutical ingredients in everyday tablets and capsules. The conversion of an amorphous form to the crystalline state either during storage or drug…
Bigger or Smaller? Size and Loading Effects on Nanoparticle Uptake Efficiency in the Nasal Mucosa
PLGA nanoparticles hold great promise for nasal administration, but only with careful design will efficient, effective, and safe delivery systems be developed. To better understand the size dependence of nasal epithelial uptake, PLGA…
A multivariate statistical approach to analyze the impact of material attributes and process…
The purpose of this work is to develop a statistical methodology that identifies the correlations among critical material attributes, critical process parameters, and critical quality attributes of a volumetric vertical micro-auger dosing…
Expanding the toolbox of surfactants available for biologics formulations with Kolliphor® HS 15 and…
The purpose of this study was to evaluate the performance of the surfactants Polyoxyl 15 Hydroxystearate (Kolliphor® HS 15) and Polyoxyl-35-castor oil (Kolliphor® ELP) in stabilizing proteins formulations. Surfactants are an essential…
Development of Sustained Release Lipid-Based Matrix Microparticles for Vaginal Delivery using…
The development of sustained-release formulations for drugs administered via the vaginal route has the potential to increase treatment efficiency and patient compliance. One promising strategy to formulate such dosage forms is the…
Taste Masking of Drug Layered Pellets with the Kollicoat® Smartseal 100P
Taste-masking has proven to be a useful technique to improve patient compliance of oral dosages having bitter actives, especially for pediatric and geriatric products. Kollicoat® Smartseal 100P, a spray dried powder of methyl…
Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt…
Hot-melt extrusion (HME) is the most preferred and effective method for manufacturing amorphous solid dispersions at production scale, but it consumes large amounts of samples when used for formulation development. Herein, we show a novel…
Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing…
The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with reduced adverse effects, for example, fatty and oily stool that have been reported to be associated with the mechanism of action of…
Bioavailability Improvement of Carbamazepine via Oral Administration of Modified-Release Amorphous…
The purpose of this study was to improve the bioavailability of carbamazepine (CBZ), a poorly water-soluble antiepileptic drug, via modified-release amorphous solid dispersions (mr-ASD) by a thin film freezing (TFF) process. Three types of…
SMEDDS And Liquisolid Compacts To Simultaneously Improve The Solubility And Processability of…
Hydrochlorothiazide (HCTZ) is a class IV BCS drug that exhibits varying bioavailability due to poor solubility and low permeability. The first part of the present investigation was aimed to prepare liquid self-microemulsifying drug delivery…
IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical…
Purpose
When establishing IVIVC, a special problem arises by interpretation of averaged in vivo profiles insight of considerable individual variations in term of time and number of mechanical stress events in GI-tract. The objective of the…
World Diabetes Day 2024
On the 14th of November is the annual World Diabetes Day. The 2024 - 2026 theme is "Diabetes and Well-being". Millions of people with diabetes around the world do not have access to diabetes care. People with diabetes require ongoing care…
Nanosuspension with improved saturated solubility and dissolution rate of cilostazol and effect of…
The aim of the study was to formulate cilostazol containing nanosuspension by top-down wet milling method in order to increase the in vitro solubility and dissolution rate of this substance. The investigation of formulation parameters…
DiCOM SANAQ® – a move forward into direct compression
Pharmatrans Sanaq introduces DICOM SANAQ® a range of co-processed excipients with high functionality as an innovative platform for higher quality direct compression (DC) formulations. The webinar will be held November 10, 2020 - 02:00 PM…
Polymers in Drug Delivery: An Update
Polymers have been an important component in the development of drug delivery systems because of their ability to release active ingredients for a longer period of time without fluctuations in plasma levels. The first polymeric based drug…
Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated…
Although electrospun nanofibers are expanding their potential commercial applications in various fields, the issue of energy savings, which are important for cost reduction and technological feasibility, has received little attention to…
Starch-based controlled release matrix tablets: Impact of the type of starch
Different types of starches were used to prepare controlled release tablets loaded with diprophylline by direct compression. The impact of the natural origin of the starch, potential chemical modifications (e.g., cross-linking with…
A Biopredictive In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone…
The objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with common food matrices and liquids.
Methods
Pediatric hydrocortisone granules were studied using a…
Design of a self-unfolding delivery concept for oral administration of macromolecules
Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due to their degradation in the gastrointestinal tract and low transmucosal permeation. In this study, the concept of an oral…
3D printing of solid oral dosage forms: numerous challenges with unique opportunities
Since the FDA approval of Spritam, there has been a growing interest in the application of 3D printing in pharmaceutical science. 3D printing is a method of manufacturing involving the layer-by-layer deposition of materials to create a…
Enhancement of solubility and dissolution rate of fenofibrate using β-Cyclodextrin
The aim of the present research work, fenofibrate a BCS class II antihyperlipidemic drug belongs to fibrate class was formulated as solid dispersions using various hydrophilic carriers to enhance the solubility, dissolution rate, and oral…