PVA-based formulations as a design-technology platform for orally disintegrating film matrices
Abstract
In the majority of pharmaceutical applications, polymers are employed extensively in a diverse range of pharmaceutical products, serving as indispensable components of contemporary solid oral dosage forms. A comprehensive understanding of the properties of polymers and selection the appropriate methods of characterization is essential…
Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique
The objective of the present investigation was to formulation development of solid dispersion of voriconazole using hot-melt, solvent evaporation and combination of these two methods together with Gelucire® 44/14, polaxamer 188 and…
Pharmacokinetics and Biodistribution of Tacrolimus after Topical Administration: Implications for…
Aim
The high doses of oral tacrolimus (TAC) (1,2) necessary to prevent acute rejection (AR) after vascularized composite allotransplantation (VCA) are associated with systemic adverse effects. The skin is the most antigenic tissue in VCA…
High-efficiency dry powder aerosol delivery to children: Review and application of new technologies
Highlights
Key aerosol and device technologies are presented that maximize delivery to pediatric airways:Nose-to-lung administration with sufficiently small particles.
Active positive-pressure DPIs
Patient interfaces that…
Cationic self-nanoemulsifying formulations of tamoxifen with improved biopharmaceutical attributes…
A cationic nanoemulsion of tamoxifen (Tmx) containing a charge inducer was developed for improving biopharmaceutical attributes and anticancer potential of the drug. The lipidic formulation constituted of corn oil, labrasol and transcutol…
Interaction between mucoadhesive cellulose derivatives and Pluronic F127: investigation on the…
Systems composed of bioadhesive and thermoresponsive polymers can combine in situ gelation with bio/mucoadhesion, enhancing retention of topically applied drugs. The effect of bioadhesive sodium carboxymethylcellulose (NaCMC) and…
Development and optimization of vitamin E TPGS based PLGA nanoparticles for improved and safe ocular…
Topical ocular delivery of therapeutics are always a challenging arena in order to achieve high ocular bioavailability with safe administration. Ideal ocular delivery of drug required 4 P's that is Patient compliance, Prolong retention,…
Mannitol in wet granulation
Wet granulation is commonly used in the pharmaceutical industry to manufacture oral solid dosage forms. Owing to many favorable attributes, mannitol is finding increasing use as a pharmaceutical binder in these formulations. Standard…
Development of a Multivariate Predictive Dissolution Model for Tablets Coated with Cellulose Ester…
The focus of the present investigation was to develop a predictive dissolution model for tablets coated with blends of cellulose acetate butyrate (CAB) 171-15 and cellulose acetate phthalate (C-A-P) using the design of experiment and…
Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds
Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or…
Creation of Filaments for 3D Printing via Hot Melt Extrusion: Evaluating Different Downstream…
Purpose: For several years now 3D printing technology has been gaining increasing attention within the pharmaceutical industry. The number of publications is rapidly increasing. One promising 3D printing technology is the fused deposition…
Patient-Centric Medicine Design: Key Characteristics of Oral Solid Dosage Forms that Improve…
Older people represent a very heterogeneous patient population and are the major user group of medication. Age-related changes mean that this population can encounter barriers towards taking medicines orally. The aim of this study was to…
A solution for low-dose feeding in continuous pharmaceutical processes
Continuous feeding of small quantities of powder is increasingly applied in pharmaceutical manufacturing. With that regard, what is crucial is not only the feasibility, but also the accuracy and stability. To enable stable processing, low…
Development and in vitro evaluation of mucoadhesive gelatin films for the vaginal delivery of…
Several strategies have been explored to obtain effective econazole nitrate (ECN) concentrations at the site of application for a prolonged time. In this paper, different gelatin-based film formulations for vaginal application were…
Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal…
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the…
Spray drying lactose from organic solvent suspensions for aerosol delivery to the lungs
Lactose is widely used as an approved excipient for dry powder inhaler (DPI) products. Spray drying technique is a rapid method for converting a liquid feed into inhalable dried particles. However, spray-dried (SD) lactose powders produced…
Lubrication Empirical Model to Predict Tensile Strength of Directly Compressed Powder Blends
A new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or compression pressure) and extent of lubrication by using empirical data to parameterise the model. This is a…
Recent Formulation Advances and Therapeutic Usefulness of Orally Disintegrating Tablets (ODTs)
Orally disintegrating or orally dispersible tablets (ODTs) are dosage forms that disintegrate or dissolve rapidly on contact with saliva. Certain ODTs that are formulated for sustained or controlled release have the ODT attribute of rapid…
Design of propolis-loaded film forming systems for topical administration: The effect of acrylic…
In situ film forming systems are an alternative to the conventional dosage forms for topical application, performing superior contact and adhesiveness, with a consequent sustained and efficacious therapy. Propolis (PRP) is an extremely…
Development and Characterization of Pullulan-based Orally Disintegrating Films Containing Amlodipine…
The aim of this study was to prepare pullulan-based orally disintegrating films (ODFs) containing amlodipine besylate, an anti-hypertensive drug, by the solvent casting method. For this purpose, nine different ODF formulations (F1-F9) were…
Characteristic Parameters and Process Maps for Fully-Filled Twin-Screw Extruder Elements
The shape and form of twin-screw extruder elements determine the physical conditions under which the material is processed. In this work, we investigated the pressure build-up, power consumption, dissipation and distributive mixing behavior…
Excipient solution for Probiotic Supplements – galenIQ by BENEO
Today, a lot of health conscious consumers improve their diets with traditional nutraceutical supplements. In the last years, probiotic supplements have been growing in importance also. They are live bacteria promoted with claims that they…
Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing
Medical cannabis has shown to be effective in various diseases that have not successfully been treated with other marketed drug products. However, the dose of cannabis is highly individual and additionally, medical cannabis is prone to…
Mechanisms of twin screw melt granulation
Twin screw melt granulation is a new alternative method for granulation that offers several advantages over wet and dry granulation methods. Twin screw melt granulation has been rapidly gaining interest over recent years in the…
3D printing of extended-release tablets of theophylline using hydroxypropyl methylcellulose (HPMC)…
An extrusion based 3D printer was used to prepare the semi-solid tablets with different drug loading dosages (75, 100, 125 mg) under ambient temperature. The active pharmaceutical ingredient, theophylline, was uploaded within the hydrogels…
Transcutol® P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery
Topical psoralens plus ultraviolet A radiation (PUVA) therapy consists in the topical application of 8-methoxypsoralen (8-MOP) followed by the skin irradiation with ultraviolet A radiation. The employment of classical 8-MOP vehicles in…
Melt Granulation: a Comparison of Granules produced via High-shear Mixing and Twin-screw Granulation
Melt granules of DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were manufactured in a twin-screw granulator (TSG) at five different conditions (screw speed and throughput varied) and compared to granules manufactured in a high-shear…
Friday’s Top 5 by pharmaexcipients
It has been some time since an excipient has been launched. This week we were able to present Reta M®: MEGGLE´s first lactose-free co-processed excipient for modified release formulations.
It is interesting to see how excipient…
Image-Based Artificial Intelligence Methods for Product Control of Tablet Coating Quality
Mimicking the human decision-making process is challenging. Especially, many process control situations during the manufacturing of pharmaceuticals are based on visual observations and related experience-based actions. The aim of the…
Development of piroxicam mini-tablets enabled by spherical cocrystallization
We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble drugs by developing a mini-tablet formulation of piroxicam. The…
Comprehensive study of co-processed excipient F- Melt®: Flow, viscoelastic and compacts properties
This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melt® type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were…
Directly compressible excipient for orally disintegrating tablets
Orally disintegrating tablets (ODTs) are one of the most popular dosage forms for improving medication adherence. ODTs disintegrate in saliva in the oral cavity without requiring water. This allows patients with dysphagia, as well as…
Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles
Poly(lactic-co-glycolic acid) (PLGA) is the most prevalent polymer drug delivery vehicle in use today. There are about 20 commercialized drug products in which PLGA is used as an excipient. In more than half of these formulations, PLGA is…
Design, Fabrication & Characterization of Graft Co-Polymer Assisted Ocular Insert: A State of…
Targeted delivery of drugs at appropriate concentrations to ocular tissues is required to avoid wastage. Hence, advanced systems that maximize the release of poorly soluble drugs and deliver them at ocular sites must be designed.
Methods:…
Large scale simulation of particle coating using coupled CFD-DEM
Spouted fluidized beds are widely used for particle coating because of its excellent mixing rates and favorable heat and mass transfer characteristics. The combination of Computational Fluid Dynamics (CFD) and the Discrete Element Method…