PVA-based formulations as a design-technology platform for orally disintegrating film matrices
Abstract
In the majority of pharmaceutical applications, polymers are employed extensively in a diverse range of pharmaceutical products, serving as indispensable components of contemporary solid oral dosage forms. A comprehensive understanding of the properties of polymers and selection the appropriate methods of characterization is essential…
Micro and Nano-drug Delivery Systems
Traditional drug formulations deliver the payload by releasing it following relatively simple physical laws, such as drug solubility or controlling its diffusion. The drug cannot always be protected from being degraded by the physiologic…
Supersaturable self-microemulsifying drug delivery system enhances dissolution and bioavailability…
To enhance the dissolution and oral bioavailability of telmisartan (TMS), a poorly water-soluble anti-hypertensive drug, a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) was developed. Amorphous alkalinized TMS (AAT)…
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot…
Silibinin Loaded Solid Lipid Nanoparticles: Effect of Different Lipids and Surfactants on…
Solid lipid nanoparticles are rapidly developing field of nanotechnology with several potential applications in drug delivery with spherical shape and an average diameter between 1 and 1000 nm. Due to their size and its properties, solid…
Electrostatics in Pharmaceutical Powders : an Insight From Molecular Level to Manufacturing –…
In this new webinar, Granutools will join forces with the RCPE to give you new insight on the importance of electrostatics for pharmaceuticals powders.
Together they will explain how the material properties, particle properties, and…
Influence of shellac on the improvement of solubility and supersaturation of loratadine amorphous…
The use of ternary amorphous solid dispersions (ASDs) comprised of surfactants and synthetic polymers to improve the solubility of low water soluble active pharmaceutical ingredients (APIs) have been widely investigated as an emerging…
Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and…
In this study, a co-processed excipient (Cop AA-MCC) was prepared from alginic acid (AA) and microcrystalline cellulose (MCC101) using a laboratory scale high-shear granulator. The obtained granules were compared to the primary materials…
Reta M®: MEGGLE´s first lactose-free co-processed excipient for modified release formulations
Co-processing specialist MEGGLE Excipients & Technology (MEGGLE) has developed Reta M®. The first hypromellose/mannitol-based, co-processed excipient specifically designed for direct compression (DC) and dry granulation of modified…
Multiparticulates for paediatric oral drug delivery – a Glatt.Pharmaceutical Services Webinar
As the demand for pediatric dosage forms continues to increase across the industry, there can be formulation challenges for this patient population. Pediatric patients may require different dosage forms depending on age ranges, and patient…
Influence of different viscosity grade Methocel and Ethocel polymers for the development of…
Dimenhydrinate is a therapeutic agent used for the treatment of nausea and vomiting. A conventional dose of dimenhydrinate is 50 mg per 8 h. Once-daily controlled release tablets of dimenhydrinate were formulated intended to treat emesis.…
Repositioning miconazole nitrate for malaria: Formulation of sustained release nanostructured lipid…
It has been previously claimed that miconazole (MNZ) has activity against Plasmodium falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an alternative antimalarial agent. MNZ was entrapped in nanostructured…
Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan.…
Storage stability of proteins in a liquid-based formulation: liquid vs. solid self-emulsifying drug…
The objective of the present study was the development of self-emulsifying drug delivery systems (SEDDS) for oral delivery of therapeutic proteins providing storage stability. Horseradish peroxidase (HRP) serving as model protein was ion…
A Comparison of Chitosan, Mesoporous Silica and Poly(lactic-co-glycolic) Acid Nanocarriers for…
Efficacious oral delivery of therapeutic proteins remains challenging and nanoparticulate approaches are gaining interest for enhancing their permeability. In this study, we explore the ability for three comparably sized nanocarriers, with…
Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders
To develop a scalable and efficient process suitable for the continuous manufacturing of poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing ovalbumin as the model protein. PLGA nanoparticles were prepared using a double…
Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone)…
Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry…
Enhancement of Curcumin Solubility Using a Novel Solubilizing Polymer Soluplus®
In this study, a novel solubility enhancement excipient (Soluplus®) was investigated to improve the solubility and dissolution rate of Curcumin, a poorly water soluble drug.
Methods
Various methods were utilized for the fabrication of…
Friday’s Top 5 by pharmaexcipients
After a week without Friday's Top 5 we are back again. It seems that lipid excipients are very much of interest - check the post "Functionalization of lipid-based formulations for oral drug delivery of insulin" and "Gattefossé - lipid…
Profound tabletability deterioration of microcrystalline cellulose by magnesium stearate
Magnesium stearate (MgSt) is a common lubricant used in tablet formulations to facilitate tablet manufacturing by reducing ejection force. The use of MgSt in tablet formulation is known to potentially deteriorate tabletability of plastic…
Development of probiotic orodispersible tablets using mucoadhesive polymers for buccal mucoadhesion
Objective: Probiotic bacteria, such as different lactobacilli strains, have successfully been used to treat gingivitis and periodontitis or caries. By formulating probiotics as orodispersible tablet (ODT), the benefits of this dosage form…
Successful Drug Development with Synthetic Lipids: Critical Aspects and Strategies
pharma's almanac - September 29, 2020 PAP-Q3-20-CL-024 - Shiksha Mantri, Ph.D. - Adela Kasselkus, Ph.D.
Lipid-based drug delivery systems offer several advantages, including improving the stability, solubility, bioavailability, and…
Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction…
Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of serious adverse events such as infusion reactions and anaphylaxis. Although select PEGylated…
Abuse deterrent immediate release film technology (ADRIFT): A novel bilayer film technology for…
Prescription opioid abuse also known as opioid epidemic has been an ever-growing problem in the United States. It has been associated with numerous emergencies and mortality with significant burden on healthcare system. Amongst various…
De-risking excipient particle size distribution variability with automated robust mixing:…
Particle size distribution (PSD) variability in excipients affects mixing. In response, manufacturers rely on raw material control and rigidly defined process parameters to achieve quality. However, this status quo is costly; and diverges…
3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted…
The establishment of 3D-printing as manufacturing process for oral solid dosage forms enables new options for the individualized medicine.
The aim of this work was to develop a novel drug-printing model using pressure-assisted…
Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA)…
This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model…
Investigation of the mucoadhesivity, swelling and drug release mechanisms of indomethacin buccal…
The purpose of this study was to investigate the effect of formulation variables on properties related to critical functionality for their use in indomethacin buccal tablets. Chitosan (CH), carbopol (PAA) and hydroxypropyl methyl cellulose…
Simulation of pellet coating in Wurster coaters
A combination of computational fluid dynamics (CFD), discrete element method (DEM), and discrete droplet method (DDM), i.e., a CFD-DEM-DDM model, was developed to simulate coating of pellets in a Wurster coater. The model equations were…
A novel method for assessing the coating uniformity of hot-melt coated particles using…
The effectiveness of hot-melt coating depends on its uniformity and the extent to which the surface is completely covered. Compared with solvent-based coating, spreading is more limited in hot-melt coating; thus, the coating uniformity is…
Formulation design and pharmacokinetic evaluation of docosahexaenoic acid containing…
Docosahexaenoic acid is a omega-3-fatty acid which together with other long-chain omega-3-fatty acid known to have protective effect against various diseases including hypertension, myocardial infarction, Alzheimer disease, and cancers.…
Powder Characterisation Techniques for Wet Granulation Applications
The challenge of developing wet granulation processes
High shear mixers are traditionally the preferred choice for wet granulation. After initial blending of the dry components, a binder solution is added, whilst mixing continues, to wet…
Have a look at our recent webinars!
We have done a series of webinars in the last months with our partners in the excipients area. They are very interesting with a lot of specialist knowledge included! See here the list of our most watched and important webinars.
Also have…
ZoomLab™-Webinar: Digitally Predicting And Optimizing Enteric-Release Coatings Formulations
A few weeks ago we did an interview with Dr. Ferdinand Brandl about ZoomLab™ in general.
Now, we had the pleasure to do a webinar about the newly introduced enteric-release coating module. Three ZoomLab™ team members (Valerie van Hulle,…
The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a…
The pharmaceutical industry is set to join the fourth industrial revolution with the 3D printing of medicines. The application of 3D printers in compounding pharmacies will turn them into digital pharmacies, wrapping up the telemedicine…