Formulation of semi-solid dosage forms indented for transdermal delivery of ivermectin
The story of ivermectin originated in 1974, when scientist Satoshi Omura discovered Streptomyces avermitilis, which later led to the isolation of an active compound, avermectin and finally, ivermectin . Ivermectin, which consists of two homologs (namely dihydro-avermectin B1b and dihydro-avermectin B1a) , is a broad-spectrum anti-parasitic drug. It…
The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a…
The pharmaceutical industry is set to join the fourth industrial revolution with the 3D printing of medicines. The application of 3D printers in compounding pharmacies will turn them into digital pharmacies, wrapping up the telemedicine…
Oral raft forming in situ gelling system for site specific delivery of calcium
In situ gelling Raft forming system (GRFS), a novel sol-gel system of calcium carbonate (CC) was developed with the aim to prolong the gastric residence time and thereby the bioavailability. A simple lattice mixture design was adopted to…
The Fundamentals Of Multi-Layer Tableting – a JRS Pharma Webinar
Multi-layer tableting offers an inexpensive and straightforward solution for a variety of challenging formulations. Enabling multi-phasic release systems, combinations of incompatible APIs, and gastro-retentive tablets, this under-utilized…
Types and evaluation of in vitro penetration models for buccal mucosal delivery
Oral buccal mucosal delivery has the advantage of avoiding gastrointestinal drug degradation, reducing hepatic firstpass effects, and improving patient compliance. In recent years, it is becoming a drug delivery route that researchers have…
Recent advances of nanocellulose in drug delivery systems
Background
Nanocellulose, which possesses great physical, chemical, and biological properties, is a natural polymer derived from widely available native cellulose. It has outstanding properties such as high mechanical strength, stiffness,…
Functionalization of lipid-based formulations for oral delivery of insulin
Insulin is a potent therapeutic molecule used for the treatment of diabetes mellitus type I and late-stage type II. Insulin is usually administered via subcutaneous (s.c.) injection, which bypasses the portal circulation and, in turn, is…
Process Control of Drug Product Continuous Manufacturing Operations—a Study in Operational…
The purpose of this manuscript is to demonstrate that implementation of gravimetric measurements provides the same assurance of product quality and process control as spectroscopic measurements (1) for control of drug content in a…
Development and Evaluation of Feline Tailored Amlodipine Besylate Mini-Tablets Using L-lysine as a…
Felines may find orally administered medicines unpalatable, thus presenting a problem in the treatment of chronic conditions such as hypertension, a commonly diagnosed condition in felines requiring daily administration of medication. A…
Quantification of Swelling Characteristics of Pharmaceutical Particles
Particle swelling is a crucial component in the disintegration of a pharmaceutical tablet. The swelling of particles in a tablet creates stress inside the tablet and thereby pushes apart adjoining particles, eventually causing the tablet to…
Building Robust Pharma Physical Properties Analysis – Webinar
Traditionally a limited number of techniques have been used for physical properties analysis.
Now, the opposite is becoming the issue, there are a multitude of good and reliable techniques, that can enrich solid form analysis.
So,…
6 reasons why to use sugar spheres
Learn more about the use of sugar spheres in this video from pharm-a-spheres™.
Sugar spheres (also called neutral pellets, nonpareil seeds, microgranules or sugar beads) are produced, preferably using a layered sugar-coating structure.…
Pharmatrans Sugar Spheres SANAQ® USP/Ph.Eur neutral pellets
Pharmatrans Sanaq’s new Sugar Spheres SANAQ® are neutral pellets made of Sucrose and maize starch that meet standards defined in the USP40-NF35, Ph. Eur and JP pharmacopoeia monographies for “Sugar Spheres”.
These white almost spherical…
Role of Polymer Physicochemical Properties on in vitro Mucoadhesion
Polymers with mucoadhesive properties are universally used in the development of mucoadhesive drug delivery system. Their physicochemical properties as well as the mechanisms related to their adhesive actions draw great attention for the…
Eudragit E 100
Commercial form:
EUDRAGIT® E 100
Solid substance
EUDRAGIT® E 100 is described in the monographs quoted above.
EUDRAGIT® E PO
Solid substance obtained from EUDRAGIT® E 100.
EUDRAGIT® E PO is described in the Ph. Eur. and JPE…
Enhanced oral bioavailability of self-Assembling curcumin-vitamin E prodrug-nanoparticles by…
Curcumin (CUR), a non-toxic natural compound with potent antitumor activity, was limited in clinical application due to its insolubility and exceedingly low bioavailability. In this study, a novel prodrug-nanoparticles (CSSV/TPGS-NPs)…
Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative…
Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and therefore is poorly absorbed. Considering that other strategies are needed to improve its bioavailability, the…
Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism.…
Microwave Induced Dielectric Heating for the On-demand Development of Indomethacin Amorphous Solid…
The poor aqueous solubility of drugs challenges their pharmaceutical development and oral bioavailability. At present, the development of dosage forms with poorly water-soluble drugs by means of amorphous solid dispersions (ASDs) approach…
How can oral paediatric formulations be improved? A challenge for the XXI century
Paediatric oral formulations need to be improved. This is an indisputable fact that has gain attention from the regulators, the medical staff, and researchers. The lack of adequate medicines developed for children, resulted in several…
Characterizing and Exploring the Differences in Dissolution and Stability Between Crystalline Solid…
Solid dispersion is one of the most effective ways to improve the dissolution of insoluble drugs. When the carrier can highly disperse the drug, it will increase the wettability of the drug and reduce the surface tension, thus improving the…
Calibration and verification of DEM parameters for the quantitative simulation of pharmaceutical…
In pharmaceutical industry, a deep understanding on the physical properties of drug substance and excipients is critical for the quality control of solid dose drug product. The purpose of this work is to develop a quantitative…
Overcoming Pharmaceutical Formulation Challenges – Fuji Chemical Webinars
7 October 2020 & 13 October 2020 – both 12:00 PM EST, 9:00 AM PST
Using Speciality Excipients from Fuji Chemical Industries to Develop High Quality Medicine.
Join Fuji in their upcoming Webinar on how to solve your…
A Biopredictive In Vitro Approach for Assessing Compatibility of a Novel Pediatric Hydrocortisone…
The objective of the present work was to screen whether a novel pediatric hydrocortisone granule formulation can be co-administered with common food matrices and liquids.
Methods
Pediatric hydrocortisone granules were studied using a…
Impact of Hot-Melt-Extrusion on Solid-State Properties of Pharmaceutical Polymers and Classification…
The impact of hot-melt extrusion (HME) on the solid-state properties of four methacrylic (Eudragit® L100-55, Eudragit® EPO, Eudragit® RSPO, Eudragit® RLPO) and four polyvinyl (Kollidon® VA64, Kollicoat® IR, Kollidon® SR, and Soluplus®)…
Stability Reports are now available in BASF RegXcellence®!
Customers can easily access and download stability data for BASF pharmaceutical products. Watch the video below to learn more about Stability Reports in RegXcellence®.
The reports provide a summary of test conditions listed by date…
Improving the dissolution of a water-insoluble orphan drug through a fused deposition modelling…
Lennox-Gastaut Syndrome (LGS) is a rare form of childhood epilepsy. Rufinamide is an orphan drug indicated for the treatment of LGS. Three-Dimensional Printing (3DP) is a process in which solid objects are created based on a digital file by…
Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy…
The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through…
Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion:…
The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques.
Methods…
Enhanced oral bioavailability of Bisdemethoxycurcumin-loaded self-microemulsifying drug delivery…
In this study, we sought to overcome the poor solubility and bioavailability of bismethoxycurcumin (BDMC) by fabricating a BDMC-loaded self micro-emulsifying system (BDMC-SMEDDS). Solubility and compatibility tests, pseudo-ternary phase…
Design and formulation of polymeric nanosponge tablets with enhanced solubility for combination…
Three drugs namely caffeine, paracetamol, and aceclofenac are commonly used for treating various acute and chronic pain related ailments. These 3 drugs have varied solubility profiles, and formulating them into a single tablet did not have…
Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing…
In this study, drug-cyclodextrin (CD) complexes were prepared using hot liquid extrusion (HLE) process with an aim to improve solubility and bioavailability of carbamazepine. Saturation solubility studies of CBZ in water and different pH…
Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical…
Over the last three decades, polymeric micelles have emerged as a highly promising drug delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules with high potency and significant toxicity were encapsulated…
Development of a Surface Coating Technique with Predictive Value for Bead Coating in the…
The aim of this paper was to investigate whether a surface coating technique could be developed that can predict the phase behavior of amorphous solid dispersions (ASDs) coated on beads. ASDs of miconazole (MIC) and…
Assessing predictability of packing porosity and bulk density enhancements after dry coating of…
Ability to predict the porosity, and its reduction after nano-silica dry coating, based on the Bond number and cohesion force estimated via multi-asperity contact model was examined for twenty different pharmaceutical powders. A new model…