Formulation of semi-solid dosage forms indented for transdermal delivery of ivermectin
The story of ivermectin originated in 1974, when scientist Satoshi Omura discovered Streptomyces avermitilis, which later led to the isolation of an active compound, avermectin and finally, ivermectin . Ivermectin, which consists of two homologs (namely dihydro-avermectin B1b and dihydro-avermectin B1a) , is a broad-spectrum anti-parasitic drug. It…
Friday’s Top 5 by pharmaexcipients
It shows that it is the World Pharmacists Day today - very interesting to see the difference to 2019. We assume Covid-19 is also a game changer here and more people show interest in the role and activities of pharmacists in the industry. We…
Water-Induced Phase Separation of Spray-Dried Amorphous Solid Dispersions
Spray drying is widely used in the manufacturing of amorphous solid dispersion (ASD) systems due to its fast drying rate, enabling kinetic trapping of the drug in amorphous form. Spray-drying conditions, such as solvent composition, can…
Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible…
The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such…
M3DISEEN: A Novel Machine Learning Approach for Predicting the 3D Printability of Medicines
Artificial intelligence (AI) has the potential to reshape pharmaceutical formulation development through its ability to analyze and continuously monitor large datasets. Fused deposition modeling (FDM) 3-dimensional printing (3DP) has made…
Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet…
This study tested 15 direct compaction grades to identify the contribution of different grades of mannitol to the storage stability of the resulting tablets. After preparing the model tablets with different values of hardness, they were…
Rheological behavior of porous pharmaceutical materials: linking torque profiles during wet massing…
Wet massing is commonly performed during the wet granulation process after the addition of a liquid binder. Torque values were measured using a Mixer Torque Rheometer (MTR) by the method of multiple additions of water and variable mixing…
How can I easily prepare a ready-to-use film coating suspension?
Here is BIOGRUNDs step-by-step guide how to prepare a suspension. Please be aware that all parameters have to be adjust individually.
Equipment & Material Equipment: propeller stirrer, beaker Material: Water, AquaPolish
Here…
Imaging of the Effect of Alcohol-Containing Media on the Performance of Hypromellose Hydrophilic…
As the ingestion of drug products with alcohol could have adverse effects on the release of drugs from dosage forms, it is important to understand the mechanisms underpinning the influence on drug release by evaluating the effect of…
Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for Emergency Use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF). TFF produces…
New pharmaceutical dosage forms used in the treatment of breast cancer. Polymeric micelles
Among all types of cancer encountered in women, breast cancer is the most prevalent, with the highest mortality rate. An increased survival rate is closely related to early diagnosis, the use of high performing screening methods and of…
Formulation and Optimization of Fluvastatin Loaded Self-emulsifying Drug Delivery Systems
Abstract-Introduction: The current research is aimed at formulating and evaluating fluvastatin self-nanoemulsifying drug delivery system (SNEDDS).
Materials and Methods: Fluvastatin SNEDDS formulated using sefsol-218…
Utility of Pickering emulsions in improved oral drug delivery
Pickering emulsions are surfactant-free emulsions stabilized by solid particles. Their unique structure endows them with good stability, excellent biocompatibility, and environmental friendliness. Pickering emulsions have displayed great…
Investigating the effect of partial neutralisation of the polymer on the dissolution characteristics…
Various active pharmaceutical ingredients (APIs) are either aggressive to the stomach’s mucosa or vulnerable to the acidic nature of the gastric juice. Solid oral dosage forms carrying one of these APIs thence require gastric resistant…
The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of…
Spray dried dispersions (SDDs) have the potential to dramatically improve the oral bioavailability of drugs with poor water solubility. However, SDDs tend to have material attributes, such as small particle size, low bulk density, and poor…
Scaling up fluidised bed coating of sustained release microparticles at high spray rate using the…
Scaling up fluidised bed coating of microparticles with particle size smaller than 150 µm is a challenge because of the high tendency of particle agglomeration. Consequently, the production yield of coating trials are unsatisfactory and low…
Nanoparticles for topical drug delivery: Potential for skin cancer treatment
Nanoparticles offer new opportunities for the treatment of skin diseases. The barrier function of the skin poses a significant challenge for nanoparticles to permeate into the tissue, although the barrier is partially compromised in case of…
Vaccine adjuvant technology by SEPPIC
The role of vaccine adjuvants in the immune response
Vaccine adjuvants (from the Latin adjuvare meaning “to help”) are substances that increase the intensity of the immune response after co-administration with an antigen. They are…
Twin-screw granulation and high-shear granulation: the influence of mannitol grade on granule and…
Granule structure has a key influence on tablet critical quality attributes. The ability to control this structure through excipient choice is an important part of formulation development. Mannitol is a popular diluent and the choice of…
Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of…
Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid…
Recent advances in colon drug delivery systems
As a result of its ability to target certain drugs and/or peptides to the colonic region for the treatment of several diseases while avoiding systemic absorption and potential side effects, colon drug delivery has become a field of research…
Investigating the influence of the core formulation on the gastric resistant functionality of a…
Developing a gastric resistant coating formulation can be quite demanding. There are a lot of interactions between polymer and active ingredient or non-functional excipients which have to be heeded. Even if all incompatibilities could be…
Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial…
Pharmaceutical 3D-printing represents a potentially new dosing and manufacturing approach for the pharmaceutical industry, with unique opportunities for personalization of dosage strengths. Fused deposition modelling (FDM) is a 3D-printing…
Implementation of formation mechanisms in DEM simulation of the Spheronization process of…
In the production process of pharmaceutical pellets with a narrow size distribution and a high sphericity, a combined extrusion-spheronization technique is frequently used. The rounding of the wet cylindrical extrudates in the spheronizer…
Applicability of impulse excitation technique as a tool to characterize the elastic properties of…
Elastic properties are of particular interest during the development of tablets especially for the definition of the formulation and of the process parameters. Impulse excitation, which is used in several industrial fields to determine…
Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid…
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint synovial inflammation, as well as cartilage and bone tissue destruction. Current strategies for the treatment of RA can reduce joint inflammation, but the…
Friday’s Top 5 by pharmaexcipients
As usual on a Friday afternoon here the Top posts of the week. Do you miss some topics? Get in touch with us!
Top posts of the week
#1 Pharmaceutical Application of Tablet Film Coating
#2 FDA DMF filings 2020
#3 What is the Role of Over…
Polymer structure and property effects on solid dispersions with haloperidol: poly(N-vinyl…
Poly(2-methyl-2-oxazoline) (PMOZ), poly(2-propyl-2-oxazoline) (PnPOZ) and poly(2-isopropyl-2-oxazoline) (PiPOZ) were synthesized by hydrolysis of 50 kDa poly(2-ethyl-2-oxazoline) (PEOZ) and subsequent reaction of the resulting poly(ethylene…
Are you experiencing a shortage of dextrose anhydrous?
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REQUEST DEXTROSE ANHYDROUS
In recent months, businesses around the globe have experienced…
Live Webcast ZoomLab™: Digitally Predicting And Optimizing Enteric-Release Coatings Formulations
Pharma Excipients and BASF Pharma are presenting a live webcast together on the newly launched enteric-release coatings module of ZoomLab™.
Monday, 28 September 2020 – 03:00 PM CEST
Drug product development is currently based on…
Zero-order drug delivery: State of the art and future prospects
Pharmaceutical drugs are an important part of the global healthcare system, with some estimates suggesting over 50% of the world's population takes at least one medication per day. Most drugs are delivered as immediate-release formulations…
USFDA’s list of drugs that need generic alternatives
In its continuous endeavor to bolster the competitiveness of the generics market, the US Food and Drug Administration (FDA) updated its list of ‘off-patent, off-exclusivity drugs without an approved generic’.
The agency updates this list…
Synthetic polymers for Microneedle synthesis: From Then to Now
Considering microneedles (MNs) as transdermal drug delivery tools is driven by some crucial factors among which easy handling, simple administration and better patient compliance are primary. Achievable tailored microneedle production…
Sensory attributes of coated tablets: Developing a formal lexicon and sensory wheel
The patient’s sensory experience when taking an oral medicine is important in the assessment of its palatability, and acceptability. The aim of this study was to develop tools useful for standardisation of sensory assessment of coated…
QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates:…
This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release (IR) pellets. HPLC-fluorescence method was developed and…