Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates:…
This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release (IR) pellets. HPLC-fluorescence method was developed and…
Effect of trehalose and melibiose on crystallization of amorphous paracetamol
This paper investigates the solid-state behavior of two-phase solid dispersions involving small molecules. The effect of two sugars, trehalose and melibiose, on the recrystallization of amorphous paracetamol, and vice versa, was…
Propolis: the beehive’s immunitary system and the invisible mask
Since ancient times food supplements have been used to improve the health and the wellness, but
today of all days it is crucial to stay healthy and strong! The watchword is “equilibrium” to be ready, reinforcing the immune system and…
Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its…
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy. Moreover, the current therapeutic…
Disintegration property of ODTs with co-processed excipients – Application note
Performance of orally disintegrating tablets (ODTs) with GRANFILLER-D was investigated by the real-time X-ray observation of water penetration into ODTs.
Orally disintegrating tablets (ODTs) have gotten attention as they improve…
Development of arsenic trioxide sustained-release pellets for reducing toxicity and improving…
Arsenic trioxide (ATO) is first-line drug for acute promyelocytic leukemia. Clinically, the continuously slow intravenous infusion is adopted to maintain effective blood concentration and reduce toxic effects, but it causes poor patient'…
World Pharmacists Day 2024
Congratulations and sincere thanks to the Pharmacists
all over the world for your daily great work!
On the 25th of September is the annual World Pharmacists Day. 2024 year's theme is "Pharmacists: Meeting global health needs".…
Mechanical Characteristics of Orally Disintegrating Films: Comparison of Folding Endurance and…
The tensile test is the most widely used method for testing the mechanical characteristics of orally disintegrating films (ODFs). The other available test is the folding endurance (FE) test, which is more suitable for clarifying the actual…
Investigating the benefits of delivering gastric resistant functionality to a tablet by applying a…
In the field of gastric resistant film-coating, a lot of obstacles can occur during formulation development. Some pharmaceutical actives (e.g. omeprazole) are prone to interactions with the functional polymer poly(methacrylic acid-co-ethyl…
Use of calcium carbonate as an excipient for release of poorly water soluble drugs: The case of…
Carbamazepine (CBZ) is a poorly water soluble drug owing to the Biopharmaceutic Classification System (BCS) class II. It is characterized by a variable bioavailability and by the presence of different polymorphs. In this paper the effects…
Mucoadhesive in situ forming gel for oral mucositis pain control
The current first line therapy for oral mucositis pain control is unsatisfactory as it results in only a short duration of modest pain relief. Developing mucoadhesive in situ forming formulations to prolong pain relief is challenging due to…
Determining the Best Poloxamer Carrier for Thiocolchicoside Solid Dispersions
Industrial pharmacists make many attempts to enhance the solubility of drugs economically. Among the various approaches for enhancing solubility, the solid dispersion (SD) approach is gaining in importance as it is simpler and requires less…
Evaluation of Lactose-Based Direct Tableting Agents’ Compressibility Behavior Using a Compaction…
A compaction simulator (CS) is a single-punch instrument that records data during the powder compaction process. The aim of the study was to determine the behavior of lactose-based direct tableting agents (DTAs) by CS. The data recorded…
β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential…
Highlights
• β-cyclodextrin polymer showed 3–4 folds higher saturation solubility of Ebselen.
• β-cyclodextrin polymer was safer on HeLa cells compared to monomeric cyclodextrin.
• EβpolySol film rapidly disintegrated and…
Pharmaceutical Application of Tablet Film Coating
Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven…
What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?
by Eccles, R. What is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?. Lung (2020). https://doi.org/10.1007/s00408-020-00390-x
Most medicines are white bitter powders that are formulated as tablets and capsules…
Friday’s Top 5 by pharmaexcipients
In September we have shared 43 posts with our network. Check the top ranking of this week. Some changes in the top pages of the month and top posts of the year.
Top posts of the week
#1 DiCOM-DC, a co-processed excipient for direct…
Preparation, optimization and preliminary pharmacokinetic study of curcumin encapsulated turmeric…
The present investigation aimed to develop curcumin loaded turmeric oil microemulsion for brain targeting. An effort has been made to investigate the role of functional components in developing brain targeted formulation which could enhance…
Comparing various plasticisers regarding their effect on the film-coating properties of Kollicoat®…
Various active pharmaceutical ingredients (APIs) are either aggressive to the stomach’s mucosa or vulnerable to the acidic nature of the gastric juice. Solid oral dosage forms carrying one of these APIs thence require gastric resistant…
FDA DMF filings 2020
In case you thought Covid-19 had slowed down the speed at which generic active pharmaceutical ingredient (API) manufacturers were submitting Drug Master Files (DMFs) to the US Food and Drug Administration (FDA), you are in for a pleasant…
The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at…
Inorganic polyphosphate (polyP) is a morphogenetically active and metabolic energy-delivering physiological polymer that is released from blood platelets. Here, we show that polyP efficiently inhibits the binding of the envelope spike…
Controlled Release of Metformin Hydrochloride for Improving the Oral Bioavailability Based on a…
This paper demonstrated that a novel enteric osmotic pump capsule (EOPC) could effectively deliver metformin hydrochloride (MH) into the small intestine and keep releasing in a sustained manner consistently. The MH EOPC was composed of…
Comparison between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol
Nebivolol (NBH) is a third-generation β1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion…
A Novel Composite Dosage Form for Buccal Drug Administration
The potential of alternative routes of application compared to the traditional oral route is constantly growing. Especially in transmucosal applications for the oral cavity, easy accessibility is an attractive feature with many new…
Cellulose and its derivatives for application in 3D printing of pharmaceuticals
Background
Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available…
Melt Dispersion Adsorbed onto Porous Carriers: An Effective Method to Enhance the Dissolution and…
The objective of the present investigation is to enhance the dissolution and flow properties of raloxifene hydrochloride (RXH), a biopharmaceutical classification system class II drug. Melt dispersion of RXH with polyethylene glycol (PEG)…
CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator
Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round,…
Application of percolation threshold to disintegration and dissolution of ibuprofen tablets with…
The study presented was conducted to determine whether a percolation threshold value, previously determined for ibuprofen/microcrystalline cellulose (MCC) blends using percolation theory and compression data (Queiroz et al., 2019), could…
Water-soluble CBD powder
Orocan is a start-up company from Switzerland focused in the cannabidiol marketplace. We are driven by the goal of providing CBD-users with a consistent high-quality product which is easy and convenient to use and a real and improved…
Amphiphilic Polyacrylamide Excipients Lead to a Record-Breaking Fast-Acting Insulin
Fast-acting insulins are central to the regulation of prandial glucose in diabetic patients. Current fast-acting insulins require 20–30 min for the onset and longer for the peak blood concentrations. The recent work by Mann et al. used…
Evaluating the impact of various aspects on the functionality of poly (methacrylic acid-co-ethyl…
Various active pharmaceutical ingredients (APIs) are either aggressive to the stomach’s mucosa or vulnerable to the acidic nature of the gastric juice. Solid oral dosage forms carrying one of these APIs thence require gastric resistant…
Reducing Friability of Tablets for Film Coating by Using Ceolus KG-1000
In the tablet film coating process, especially when it comes to large tablets especially with the size more than ø9mm, friability can be an issue at the early stage of the process. The purpose of the experiment was to confirm if Ceolus™…
A smartphone-supported portable micro-spectroscopy/imaging system to characterize morphology and…
A smartphone-based analysis system is favored for point-of-care testing applications. The present work proposes a novel micro-spectroscopy/imaging system comprising a portable spectrometer as an optical sensor and a compact homemade…
Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation…
Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug…