Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
The molecule of natural origin that inhibits SARS-CoV-2
An international study involving the Institute of Nanotechnology of the Cnr has found that quercetin acts as a specific inhibitor for the virus responsible for Covid-19, showing a destabilizing effect on 3CLpro, one of the key proteins for…
Lyophilization of Small-Molecule Injectables: An Industry Perspective on Formulation Development,…
Lyophilization is a pivotal manufacturing process to obtain a stable drug product that is unstable as a ready-to-use formulation. Some formulations may require the addition of drug-specific excipients such as stabilizers, buffers, and…
Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and…
Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of…
Evolution of the COVID-19 vaccine development landscape
The COVID-19 vaccine R&D landscape has developed at unprecedented scale and speed since our initial analysis in April identified 115 candidates in the pipeline (Nat. Rev. Drug Discov. 19, 305–306; 2020). In this updated overview, we…
Impact of Reverse Micelle Loaded Lipid Nanocapsules on the Delivery of Gallic Acid into Activated…
Gallic acid (GA) is a polyphenolic compound with proven efficacy against hepatic fibrosis in experimental animals. However, it suffers from poor bioavailability and rapid clearance that hinders its clinical investigation. Accordingly, we…
Development of an abuse deterrent formulation using hot melt extrusion – Thesis
In recent years prescription drug diversion, misuse, abuse represent a growing problem for the United States. Oral ingestion, snorting, injection are most commonly employed routes of abuse. To circumvent this problem hot melt extrusion…
Remdesivir: First Approval
The antiviral agent remdesivir (Veklury®; Gilead Sciences), nucleotide analogue prodrug, has broad-spectrum activity against viruses from several families. Having demonstrated potent antiviral activity against coronaviruses in preclinical…
Monoolein Assisted Oil-Based Transdermal Delivery of Powder Vaccine
An increasing number of protein vaccines have been researched for cancer, inflammation, and allergy therapies. Most of the protein therapeutics are administered through injection because orally-administered proteins are metabolized by the…
Cannabidiol aqueous solubility enhancement: Comparison of three amorphous formulations strategies…
Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming…
Friday’s Top 5 by pharmaexcipients
As every Friday - find the top posts of the week!
Top posts of the week
#1 Chinese Excipient DMF
#2 ZoomLab™ – The interview with Dr. Ferdinand Brandl from BASF
#3 Development and Evaluation of Astaxanthin Orally Disintegrating Tablets…
Quality of Water for Pharmaceutical Use – ISPE Video
This training is intended to provide guidance to the audience on the pharmaceutical use of different grades of water from a European regulation perspective. The control of the microbiological quality of water is extremely important. A…
Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of…
Graphene oxide (GO) is an amphiphilic, high surface area material with great potential as a functional excipient in drug delivery. The present study aimed at incorporating GO in buccal polyelectrolyte films for delivery of antifungal drugs…
Novel Water-Soluble Lubricant for the Preparation of Tiemonium Methylsulfate Fast-Dissolving Tablets
The rapid delivery and self-administration of antispasmodics are very essential for the treatment of pain associated with smooth muscle spasms. Tiemonium methylsulfate (TMS) is a well-known antispasmodic drug used in the treatment of muscle…
Mechanisms of Water Permeation and Diffusive API Release from Stearyl Alcohol and Glyceryl Behenate…
This work aims to develop complimentary analytical tools for lipid formulation selection that offer insights into the mechanisms of in-vitro drug release for solid lipid MR excipients. Such tools are envisioned to aide and expedite the time…
DiCOM-DC, a co-processed excipient for direct compression – Webinar
In this webinar organised by the School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune you will learn more about DiCOM-DC, a co-processed excipients for direct compression.
Day, Date and Time: Saturday, September 5,…
Optimize the cost of your tablets by using Directly Compressible Excipients – Webinar
Why should I attend?
- Understand the design process of Direct Compression
- Risk Assessment of DC Process
- Understand the cost effectiveness of DC method vs. granulation method
Event Details:
Date: 15th September, 2020
Webinar…
Nanostructured lipid carriers loaded with curcuminoids: Physicochemical characterization, in vitro…
Four formulations of nanostructured lipid carriers (NLC) loaded with curcuminoids where prepared, testing two types of solid lipids (Compritol® 888 ATO and Precirol® ATO 5) and two kinds of stabilizers (poloxamer 407 and polysorbate 80).…
Fused deposition modeling of API-loaded mesoporous magnesium carbonate
In this thesis, the incorporation of drug loaded mesoporous magnesium carbonate as an excipient for the additive manufacturing of oral tablets by fused deposition modeling was investigated. Cinnarizine, a BCS class II drug, was loaded into…
Safe, swallowable and palatable paediatric mini-tablet formulations for a WHO model list of…
More than 10 years after the Paediatric Regulation came into place there is still a strong need for pure paediatric medicines for off-patent drug substances. Numerous compounds for which a paediatric formulation does not exist can be found…
Omeprazole nanoparticles suspension: development of a stable liquid formulation with a view to…
Omeprazole (OME) is often used to treat disorders associated with gastric hypersecretion in children but a liquid pediatric formulation of this medicine is not currently available. The aim of this study is to develop OME loaded…
Nanoparticles in the Biological Context: Surface Morphology and Protein Corona Formation
A recent paper demonstrated that the formation of a protein corona is not a general property of all types of nanosized objects. In fact, it varies between a massive aggregation of plasma proteins onto the nanoparticle down to traces (e.g.,…
Kollicoat® MAE: comparing the three different grades regarding preparation and functionality…
Various active pharmaceutical ingredients (APIs) are either aggressive to the stomach’s mucosa or vulnerable to the acidic nature of the gastric juice. Solid oral dosage forms carrying one of these APIs thence require gastric resistant…
Optimizing Lipid-Based Formulation for Commercial Success – Webinar
Join this live 90-minute virtual workshop to hear experts present on the fundamental principles, strategies, and advantages of lipid-based drug delivery for enabling commercial success. Presentations from BASF and Catalent will demonstrate…
Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired…
The objective of this work was to develop taste-masked donut-shaped tablet formulations utilizing fused filament fabrication three-dimensional printing paired with hot-melt extrusion techniques. Caffeine citrate was used as the model drug…
Design and In Vitro Evaluation of Solid SEDDS for Breast Cancer Therapy
Lipid-based drug delivery systems have been used as a useful tool for the formulation of hydrophobic drugs giving us the opportunity to enhance permeation from biological membranes, protecting active ingredients from harsh in vivo…
ZoomLab™ – The interview with Dr. Ferdinand Brandl from BASF
ZoomLab™ is the Virtual Pharma Assistant from BASF. Pharma Excipients had the chance to interview one of the "masterminds" behind ZoomLab™, Dr. Ferdinand Brandl. Ferdinand answered all our questions on ZoomLab™.
See the video of the…
Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain…
Multiparticulates Webinar Series Part III: Multiparticulates From Matrix Core Pellets – Glatt…
Thursday, 10 September 2020 – 03:00 PM CEST
Multiparticulates such as micropellets, pellets, granules and mini-tablets represent modern and innovative technology platforms. Multiparticulates can provide a number of advantages compared with…
Effect of Hydroxypropyl Cellulose Level on Twin-Screw Melt Granulation of Acetaminophen
This study investigated the effect of binder level on the physicochemical changes and tabletability of acetaminophen (APAP)-hydroxypropyl cellulose (HPC) granulated using twin-screw melt granulation. Even at 5% HPC level, the tablet tensile…
Self-emulsifying drug delivery systems: hydrophobic drug polymer complexes provide a sustained…
The aim of this study was to develop hydrophobic ionic drug polymer complexes in order to provide sustained drug release from self-emulsifying drug delivery systems (SEDDS). Captopril (CTL) was used as an anionic model drug to form ionic…
An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction…
Liquisolid technology, as a promising approach for bioavailability enhancement, has received increasing attention in recent years. However, literature reports addressing the challenges for its industrial application, particularly those…
Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model…
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications. The reasons for this are probably…
Preparation and in vitro characterization of rosuvastatin calcium incorporated methyl beta…
Despite being the most effective hypolipidemic agent, poor physicochemical properties of Rosuvastatin calcium (RCa) remain challenging obstacles in the development of pharmaceutical dosage forms. Inclusion complexes (ICs) of RCa with…
Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art
Highlights
• Film technology provides platforms adaptable to the desired drug release profile.
• Several natural and synthetic polymers have been considered to obtain vaginal films.
• Plasticisers and other excipients allow…