Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
pH-Responsive Gamma-Irradiated Poly(Acrylic Acid)-Cellulose-Nanocrystal-Reinforced Hydrogels
A pH-sensitive poly(acrylic acid) composite hydrogel was successfully synthesized via gamma irradiation and reinforced with cellulosic materials of different sizes. Cellulose was extracted from rice husks via alkali and bleaching treatment,…
Novel high-drug-loaded amorphous dispersion tablets of posaconazole
Amorphous solid dispersions (ASDs) can increase bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and therefore large…
Friday’s Top 5 by pharmaexcipients
In 2020 pharmaexcipients.com has shared over 800 articles so far which is about 3 posts per day. This shows how much topics are related with pharmaceutical excipients and how important they are for the drug product development and…
Evaluating the suitability of a pH-dependent pore former in a sustained release film-coating…
Since the development of polymers for enteric coating in the late 1950’s, numerous investigations have illustrated the application of these functional excipients such as poly(methacrylic acid-co-ethyl acrylate). Also mixtures with other…
A study on the influence of the dissolution test factors on in vitro release of ibuprofen from…
Objectives
The aim of this study was to investigate the influence of in vitro release test parameters on the release of ibuprofen from sustained release inert matrix tablets.
Materials and methods
Ibuprofen sustained release inert…
Development and Evaluation of Astaxanthin Orally Disintegrating Tablets Prepared from Coprocessed…
The world’s population is aging; therefore, conventional pharmaceutical dosage forms designed for adult are not suitable. Orally disintegrating tablets (ODTs) are innovative dosage forms designed to overcome the problem of difficulty in…
Interfacial tension effects on the properties of PLGA microparticles
Today, many types of long-acting injectables have been developed and ultimately benefited numerous patients. The advantages of using long-acting injectables include greater patient compliance and more steady state drug plasma levels for…
Transdermal delivery of peptide and protein drugs
Peptide and protein drugs (PPDs) that possess the advantages of high specificity and tolerance, and low immunogenicity can effectively treat diabetes, osteoporosis, cancer, and genetic defects. However, the high molecular weight and poor…
Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage…
New Generation direct compression excipient for ODTs
HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between oral disintegration time and tablet hardness.
HiSORAD is composed of three compendial grade…
Novel analytical approaches for solid dispersion characterization
The overall aim of the thesis was to introduce new analytical techniques to characterize solid dispersion formulations. Solid dispersion formulations are employed to enhance the dissolution behavior and apparent solubility of poorly soluble…
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment
Ultra-small nanostructured lipid carriers (usNLCs) have been hypothesized to promote site-specific glioblastoma (GB) drug delivery. Envisioning a multitarget purpose towards tumor cells and microenvironment, a surface-bioconjugated usNLC…
Hand sanitizer virucidal testing, excipients and formulation information by SEPPIC
Seppic has confirmed through external testing the virucidal activity* of below hydroalcoholic gel formulas according to the EN 14476 standard.
* virucidal against enveloped viruses (Modified vaccinia virus Ankara), virucidal with limited…
Strategies to optimize the development of biopharmaceuticals: the influence of the culture medium…
One major challenge for Biotech companies is to optimize product development time while pursuing high productivity. The culture medium is a critical component in this equation and the use of the right ingredients will enable a decrease in…
METHOCEL™ Cellulose Ethers – versatile excipients in continuous production and many other…
Did you know that the METHOCEL™ products have been in continuous production for more than 70 years with facilities and deep polymer expertise from our experts located around the globe. Find out more about what this polymer delivers in…
A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for…
Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing…
Overcome CBD formulation challenges with solutions from Fuji Chemical
Do you want to develop a tablet, capsule, ODT or a powder for a drink mix or bar using cbd oil and are facing some formulation challenges? FujiChemical offers interesting solutions for this:
Learn more in the following video…
Nitrosamines Risk Assessments for BASF’s pharmaceutical excipients
Nitrosamines Risk Assessments for BASF’s pharmaceutical excipients are now available for instant download in RegXcellence™! These statements enable you to better understand potential risk for Nitrosamine formation and presence.
What are…
Evaluating drug distribution and release in ophthalmic emulsions: Impact of release conditions
The purpose of this study is to investigate the process of drug distribution and mechanism of drug release of ophthalmic emulsions in the context of factors associated with the drug release. Cyclosporine and difluprednate emulsions were…
Hybridized nanoamorphous micellar dispersion using a QbD–DM3 linked rational product design strategy…
A QbD-DM3 linked rational product design strategy was adopted to create a hybridized ritonavir (RTV, BCS Class IV) nanoamorphous micellar dispersion (RTV-NAD). A DM3 research strategy was employed in conjunction with the quality-by-design…
Studying effect of glyceryl palmitostearate amount, manufacturing method and stability on…
Rifaximin (RFX) exhibit polymorphism and commercial formulation contains the α form. The polymorphic transformation of the RFX in the drug product have significant effect on the clinical outcome. The focus of present work was to understand…
Preparation of delayed-release multiparticulate formulations of diclofenac sodium and evaluation of…
Diclofenac sodium was used as a model drug for preparation of delayed-release (DR) multiparticulates, which were further processed into solid oral dosage forms such as capsules and tablets. Multiple unit pellets systems (MUPS) were prepared…
Conversion of α-lactose monohydrate to anhydrous form with superior tabletability by twin-screw…
The purpose of this study was to improve tabletability (tensile strength versus compaction pressure) of α-lactose monohydrate by twin screw extrusion (TSE) near its dehydration temperature but below its melting point. When extruded at 150…
Synergistic and antagonistic effects of non-ionic surfactants with bile salt + phospholipid mixed…
The nature of the interaction of bile salt micelles with exogenous surfactants used in formulations and the consequent impact on drug solubilisation is not well understood. It is often assumed that addition of any surfactant will lead to an…
Nanoprecipitation: Applications for Entrapping Active Molecules of Interest in Pharmaceutics
Nanoprecipitation technique, also named solvent injection, spontaneous emulsification, solvent displacement, solvent diffusion, interfacial deposition, mixing-induced nanoprecipitation, or flash nanoprecipitation, is recognized as a useful…
Comparison between twin-screw and high-shear granulation – The effect of filler and active…
Highlights
• Twin-screw granulation was less sensitive for liquid amount used.
• API compaction properties had only minor effect on the tablet tensile strength.
• Tablets made of TSG granules had a higher tensile strength…
Non-Destructive Quantification of Fragmentation Within Tablets After Compression From Scattering…
Material deformation behaviour has a critical impact on tablet formation. Fragmentation is one of the key mechanisms affecting the strength of a final compact, however, quantitative methods for estimating fragmentation are often complex,…
Friday’s Top 5 by pharmaexcipients
Another week full of great scientific publications - find the one you liked most! Top post of the last 30 days is still "How to improve API Bioavailability?"as you can also see in the Top post of 2020.
Top posts of the week
#1 Chinese…
Hybrid Pectin-Liposome Formulation against Multi-Resistant Bacterial Strains
This work describes the development of a gastroresistant antimicrobial formulation composed of two carriers, pectin and liposomes, intended to improve the efficiency of norfloxacin (NOR) against multi-resistant bacterial strains. The…
Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products
Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under…
A review on developments and prospects of anti-inflammatory administration in microemulsions
Anti-inflammatory drugs often cause diverse side effects and have high lipophilicity, therefore there is a need to search for new anti-inflammatory agents or new drug delivery systems (NDDS) that improve their characteristics. Thus,…
Cellular uptake of self-emulsifying drug-delivery systems: polyethylene glycol versus polyglycerol…
Aim: Comparison of the impact of polyethylene glycol (PEG) and polyglycerol (PG) surface decoration on self-emulsifying drug delivery system (SEDDS)-membrane interaction and cellular uptake
Materials & methods: PEG-, PEG/PG- and…
Preparation of Hot-Melt Extruded Dosage Form for Enhancing Drugs Absorption Based on Computational…
The aim of this study was to control the dissolution rate and permeability of cilostazol. To enhance the dissolution rate of the active pharmaceutical ingredient (API), hot-melt extrusion (HME) technology was applied to prepare a solid…
Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally…
Orally disintegrating tablets (ODTs) manufactured by freeze-drying, also called oral lyophilizates, are a patient-centred dosage form. They possess ultra-fast disintegration dynamics, have acceptable mechanical strength and have a smooth…