Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Nanotechnology-based antiviral therapeutics
The host immune system is highly compromised in case of viral infections and relapses are very common. The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges…
The COVID-19 Vaccine Race: Challenges and Opportunities in Vaccine Formulation
In the race for a safe and effective vaccine against coronavirus disease (COVID)-19, pharmaceutical formulation science plays a critical role throughout the development, manufacturing, distribution, and vaccination phases. The proper choice…
Preparation, characterization, and pharmacokinetics of tilmicosin taste-masked formulation via…
Tilmicosin (TMS) is a macrocyclic antibiotic specially used in veterinary clinics, but its extreme bitterness limits its use. This study aimed to obtain a taste-masked formulation of TMS by hot melt extrusion (HME) technology and to…
Design of telmisartan-weak acid solid dispersion to improve its solubility and stability
Telmisartan (TEL), an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. However, low solubility of TEL has resulted in solubilized commercial products with alkalizers. On the contrary, our study aims to…
Orphan Formulations for Pediatric Use: Development and Stability Control of Two Sildenafil Citrate…
Sildenafil citrate causes vasodilatation, relaxation of the smooth muscle, and reduction of pulmonary arterial pressure. The latter property makes sildenafil citrate efficient for the treatment of cardiovascular diseases, including…
Crystallization inhibition for enhanced bioavailability – BASF functional solutions for solid and…
Crystallization inhibition is an important factor to maintain drug solubility and bioavailability out of solid and liquid dosage forms in particular. BASF offers a range of well established crystallization inhibitors that ensure that your…
Friday’s Top 5 by pharmaexcipients
Another week full of great scientific publications - find the one you liked most!
Top posts of the week
#1 Webinar: Reduce the cost of your tablets by using directly compressible excipients
#2 Soluplus-Mediated Diosgenin Amorphous Solid…
In Silico Investigation of First-Pass Effect on Selected Small Molecule Excipients and Structural…
In this study, the interaction of selected pharmaceutical excipients on the function of P-glycoprotein (P-gp) and activity of 6 cyto- chrome P450 (CYP) isoforms were computationally investigated. At binding free energy cut-off value of −5.0…
Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental…
Supersaturable SMEDDS, a versatile dosage form, was investigated for improving the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug efavirenz.
Objective: The present research pursues development…
Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic…
The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First,…
Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro…
The improvement of drug solubility is a challenging task in the pharmaceutical industry; moreover, drug stability is also important. This study was designed to improve the dissolution (%) and in vitro anti-inflammation effects of piroxicam…
Effects of Formulation Excipients on Skin Barrier Function in Creams Used in Pediatric Care
Semisolid dosage forms are recommended for the dermal care of babies and children.
If we look at the ingredients of these preparations, there are still many cases in which there are
substances (occlusive agents, preservatives) that no…
Novel Excipients: Gaining Traction in the Industry
By Patricia Van Arnum - DCAT Editorial Director - August 5, 2020
The FDA is considering a pilot program for the toxicological and quality evaluation of novel excipients. Excipients now are not separately reviewed by the FDA, and some say…
Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets…
The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms with food carriers is often necessary to ease swallowing and provide the taste-masking effect. The…
Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria
A model anaerobic bacterium strain from the gut microbiome (Clostridium butyricum) producing anti-inflammatory molecules was incorporated into polymer-free fibers of a water-soluble cyclodextrin matrix (HP-β-CD) using a promising scaled-up…
Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin…
A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed to improve nail…
VaxiPatch™, a novel vaccination system comprised of subunit antigens, adjuvants and microneedle skin…
This work introduces VaxiPatch, a novel vaccination system comprised of subunit glycoprotein vaccine antigens, adjuvants and dermal delivery. For this study, rHA of influenza virus B/Colorado/06/2017 was incorporated into synthetic…
Asahi Kasei Providing Samples of Hyaluronic Acid Nanogel as a New Pharmaceutical Excipient
Advancing toward commercialization as base material for drug delivery systems
August 04, 2020 10:00 PM Eastern Daylight Time
TOKYO--(BUSINESS WIRE)-- Asahi Kasei has established industrial manufacturing technology…
Webinar: Reduce the cost of your tablets by using directly compressible excipients
Join the tableting experts of Kerry for a live webinar where they will be discussing how direct compression tableting method helps in bringing down the overall cost of your tablets and various factors that influence the design of direct…
Formulation development and evaluation of Silybum marianum tablets
In popular medicine Silybum marianum is used as a hepatoprotective agent. Silymarin is the major constituent. The present work deals with the formulation and evaluation of S. marianum tablets from ethanolic extract by direct compression.…
Formulating Cannabinoids
Cannabinoids are challenging APIs to formulate:
Being highly lipophilic compounds with low water solubility, cannabinoids need to be solubilized for subsequent absorption in the gastro-intestinal tract
With high first-pass…
How to Clean Sustained-Release Polymers
by Priya Poduval | July 22, 2020
Solubilizing SR excipients are difficult unless solvents are used for cleaning. Most of the companies using this method have a similar cleaning process – manual application using a lint-free wipe followed…
New Research Reveals a Promising Functional Alternative to Surfactants within Biologic Formulations
One of the most common challenges when formulating biological molecules for therapeutic use is overcoming the molecules’ tendency to aggregate. Currently, the nonionic surfactants polysorbate 80 and polysorbate 20 are widely used to…
Characterization and modeling of the viscoelasticity of pharmaceutical tablets
Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be…
FDA Approves New Indication for Drug Containing an Active Ingredient Derived from Cannabis to Treat…
Today, the U.S. Food and Drug Administration approved Epidiolex (cannabidiol) oral solution for the treatment of seizures associated with tuberous sclerosis complex (TSC) in patients one year of age and older. Epidiolex was previously…
Water-assisted synthesis of mesoporous calcium carbonate with a controlled specific surface area and…
A carbonation process to control the specific surface area of mesoporous calcium carbonate and the dissolution profile of ferulic acid on mesoporous carbonate particles are presented. The effects of water content on the physicochemical…
Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability:…
The traditional Chinese medicine, diosgenin (Dio), has attracted increasing attention because it possesses various therapeutic effects, including anti-tumor, anti-infective and anti-allergic properties. However, the commercial application…
Effect of TPGS surfactant on dissolution sensitivity of a poorly water-soluble drug using high-shear…
d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been widely used in a variety of oral applications to enhance dissolution, solubility, and/or bioavailability of poorly-water soluble drugs. In addition, the use of TPGS could…
Introduction of the energy to break an avalanche as a promising parameter for powder flowability…
Dynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder excipients, break energy (BE) is introduced as a new promising avalanche parameter. Conventional…
3D printed gummies: Personalized drug dosage in a safe and appealing way
Obtention of customized dosage forms is one of the main attractions of 3D printing in pharmaceuticals. In this sense, children are one of the groups within the population with a greater need for drug doses adapted to their requirements…
Efficient skin delivery with Transcutol P
Transcutol® P is a high purity grade of diethylene glycol monoethyl ether (DEGEE) manufactured by the condensation of ethylene oxide and ethanol, followed by distillation. The presence of an ether and an alcohol function explains the…
Design and Characterization of Bioactive Bilayer Films: Release Kinetics of Isopropyl Palmitate
Active packaging incorporating antioxidants and antimicrobials is creating a niche in the market and becoming increasingly important. The main goal of this work was the design of bioactive bilayer films (zein/pullulan) incorporating…
Friday’s Top 5 by pharmaexcipients
Another week full of great scientific publications - find the one you liked most!
Top posts of the week
#1 Hot-Melt Extrusion – Enabling Technologies from Dupont
#2 Tablet Quality-Prediction Model - Toward Flexible Switching Between…
Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer
Background
Pyridoclax is an original lead, recently identified as very promising in treatment of chemoresistant ovarian cancers. To correct the unfavorable intrinsic physico-chemical properties of this BCS II drug, a formulation strategy…