Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Nanocrystal-chitosan particles for intra-articular delivery of disease-modifying osteoarthritis…
Osteoarthritis is the most common chronic joint disease and a major health care concern due to the lack of efficient treatments. This is mainly related to the local and degenerative nature of this disease. Kartogenin was recently reported…
In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and…
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the…
Quantitative analysis of wet kneading states by a novel compression test
Kneading is a process that mixes powders with liquid to produce homogeneous wet powders, with the process of kneading significantly affecting the quality and productivity of the final product. However, most kneading operations are…
Chitosan coated lipid carriers as nanoplatform for repurposed anti-breast cancer activity of…
Drug repurposing is promising strategy with niclosamide showing encouraging results against breast cancer. However, niclosamide hydrophobicity limits its oral bioavailability and minimizes its anti-cancer activity. Nano-structured lipid…
Taste Masking of Dexketoprofen Trometamol Orally Disintegrating Granules by High-Shear Coating with…
Abstract
Orally disintegrating granules (ODGs) are a pharmaceutical form commonly used for the administration of NSAIDs because of their easy assumption and fast dispersion. The development of ODGs is not easy for drugs like dexketoprofen…
Swissmedic updated its requirements for dealing with potential nitrosamine impurities in medicinal…
In summer 2018, drug regulatory authorities first became aware of nitrosamine impurities in a number of medicinal products, including antihypertensives in the sartans class. Trace amounts of nitrosamine impurities were also subsequently…
In Vitro and In Vivo testing of 3D-Printed Amorphous Lopinavir Printlets by Selective Laser…
The aim of this paper was to investigate the effects of formulation parameters on the physicochemical and pharmacokinetic (PK) behavior of amorphous printlets of lopinavir (LPV) manufactured by selective laser sintering 3D printing method…
Determining the Impact of Roller Compaction Processing Conditions on Granulate and API Properties:…
Previous work demonstrated that roller compaction of a 40%w/w theophylline–loaded formulation resulted in granulate consisting of un-compacted fractions which were shown to constitute between 34 and 48%v/v of the granulate dependent on…
Changes in Tablet Color Due to Light Irradiation: Photodegradation of the Coating Polymer,…
The color of the tablets and capsules produced by pharmaceutical companies is important from the perspectives of product branding and counterfeiting. According to some studies, light can change tablet color during storage. In this study,…
Chitosan film of thiolated TPGS-modified Au-Ag nanoparticles for combating multidrug-resistant…
The widely used vitamin-E based amphiphilic material, tocopheryl polyethylene glycol succinate (TPGS) is further improvised as redox-sensitive thiolated TPGS (TPGS-SH), which has been developed by attaching 4-aminothiophenol. Further, TPGS…
Cleaning of Direct Compression Continuous Manufacturing Equipment through displacement of API…
Abstract
This feasibility study evaluates a cleaning process designed to avoid the use of detergents and reduce operator exposure to the active pharmaceutical ingredient (API). The continuous manufacturing equipment was cleaned using…
Roquette´s MICROCEL® microcrystalline cellulose family is growing
Microcrystalline Cellulose
MICROCEL® Microcrystalline cellulose is used as a filler/binder as well as a fiber source in various oral dosage forms in both pharmaceutical and nutraceutical applications. Microcrystalline cellulose has a long…
3D printing in vaginal drug delivery: a revolution in pharmaceutical manufacturing
Introduction
The Food and Drug Administration’s approval of the first three-dimensional (3D) printed tablet, Spritam®, led to a burgeoning interest in using 3D printing to fabricate numerous drug delivery systems for different routes of…
A novel methodology for data analysis of dynamic angle of repose tests and powder flow…
We present a new post-processing methodology to analyse powder flow image data gathered via dynamic angle of repose tests. We aim to expand the flow descriptors, allowing a more detailed and nuanced measurement of flow rheology. This makes…
CBD Oil Tablets Chewable – Direct Compression with PROSOLV 730
Aim of the Study
Due to the physico-chemical properties of cannabidiol (CBD), the vast majority of the marketed products containing CBD are oils. To provide greater convenience in dosing, the goal of this experiment was to make…
Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular…
Recent studies have demonstrated that Sirtuin-1 (SIRT-1)-activating molecules exert a protective role in degenerative ocular diseases. However, these molecules hardly reach the back of the eye due to poor solubility in aqueous environments…
Developing a pharmaceutical Fluid bed granulation & drying process via design of experiments…
This manuscript presents a lean industrial workflow to establish an operating design space for a commercial scale fluid bed granulation and drying process. The workflow involves confirming the operating design space by demonstrating that…
Breaking Boundaries in Veterinary Medicines – webinar series
Gattefossé Pharmaceuticals is presenting a webinar series focusing on veterinary medicines. These webinars are specifically designed for formulators in veterinary laboratories worldwide, providing them with comprehensive insights into the…
Addiction to Psychoactive Prescription Drugs: Can the Excipients of the Formulations Play a Role?
Abstract
In the development of drugs misuse and addiction, references are often made to the study of the API (active principle ingredient) as the main cause, which is certainly true, but there is a tendency to overlook the possible role of…
Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate
Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle…
Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving…
The lymphatic system possesses the main viral replication sites in the body following viral infection. Unfortunately, current antiretroviral agents penetrate the lymph nodes insufficiently when administered orally and, therefore, cannot…
An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production…
Abstract
Three-dimensional printing (3DP) technologies are characterized as a set of innovative manufacturing techniques that allow for the creation of complex and/or personalized three-dimensional physical objects on the work surface of a…
Hydroxyapatite and pore former effects on the microstructure and mechanical strength of porous…
Porous hydroxyapatite (HAP) pellets were prepared by extrusion/spheronization/sintering and loaded with Lactobacillus (La-5). Micronized (PFm) or coarse size (PFc) microcrystalline cellulose were the pore formers, while HAP grades from…
Extending the Use of Optical Coherence Tomography to Scattering Coatings Containing Pigments
Coating thickness is a critical quality attribute of many coated tablets. Functional coatings ensure correct drug release kinetics or protection from light, while non-functional coatings are generally applied for cosmetic reasons.…
Artificial intelligence generates novel 3D printing formulations
Formulation development is a critical step in the development of medicines. The process requires human creativity, ingenuity and in-depth knowledge of formulation development and processing optimization, which can be time-consuming. Herein,…
Oral Self-Nanoemulsifying System Containing Ionic Liquid of BX795 Is Effective against Genital HSV-2…
BX795 is an emerging drug candidate that has shown a lot of promise as a next-generation non-nucleoside antiviral agent for the topical treatment of herpes simplex virus type-1 (HSV-1) and herpes simplex virus type-2 (HSV-2) infections. Our…
Potentially Harmful Excipients: State of the Art for Oral Liquid Forms Used in Neonatology and…
Abstract
The pediatric population exhibits an important age-dependent heterogeneity in pharmacokinetics and pharmacodynamics parameters, resulting in differences in drug efficacy and toxicity compared to the adult population, particularly…
Nanoparticles targeting the intestinal Fc receptor enhance intestinal cellular trafficking of…
Semaglutide is the first oral glucagon-like peptide-1 (GLP-1) analog commercially available for the treatment of type 2 diabetes. In this work, semaglutide was incorporated into poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG)…
Multilevel categoric factorial design for optimization of raloxifene hydrochloride solid dispersion…
Raloxifene Hydrochloride (RLH) is a selective estrogen receptor modulator (SERM) used for the treatment and prevention of postmenopausal osteoporosis. This Active Pharmaceutical Ingredient (API) belongs to class II biopharmaceutics…
Electromechanical convective drug delivery devices for overcoming diffusion barriers
Abstract
Drug delivery systems which rely on diffusion for mass transport, such as hydrogels and nanoparticles, have enhanced drug targeting and extended delivery profiles to improve health outcomes for patients suffering from diseases…
Pharmeuropa 36.1 just released
All new European Pharmacopoeia (Ph. Eur.) texts that have undergone technical revisions are published in Pharmeuropa for public consultation. The deadline for comments on Pharmeuropa 36.1 is 31 March 2024.
Users and interested parties…
Understanding the Impact of Formulation Design on Microstructure and Drug Release from Porous…
For proportionally formulated intermediate strengths of a topical product, the relationship of drug release across multiple strengths of a given product is not always well understood. The current study aims to assess the proportionality of…
Design, development and scale up studies of metformin hydrochloride multiparticulate system: A…
Metformin hydrochloride (MH) is prescribed for treating diabetes mellitus. The most popular dosage form, viz., tablets has a bulky nature as MH dose ranges up to 1000 mg leading to large size. In geriatric or dysphagic patients, due to…
Study of Compaction Tools and Parameters on Critical Quality Attributes of High Drug Load…
Minitablets are prepared using multiple die openings and multi–tip punches for greater productivity. With multiple tips on the punch barrel, the overall compaction force to be applied is commonly estimated by multiplying the desired…