Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved…
The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were…
Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective…
The development of an efective oral therapeutics is an immediate need for the control and elimination of visceral leishmaniasis (VL). We exemplify the preparation and optimization of 2-hydroxypropyl-β-cyclodextrin (HPCD) modifed solid lipid…
Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug…
Electrospinning has emerged as most viable approach for the fabrication of nanofibers with several beneficial features that are essential to various applications ranging from environment to biomedicine. The electrospun nanofiber based drug…
3D printing for enhanced drug delivery: current state-of-the-art and challenges
Three-dimensional (3D) printing has recently appeared as one of the most promising additive manufacturing techniques to fabricate 3D objects, with uses spanning from engineering prototyping to medicines and cell-laden models for biomedical…
Enhanced oral delivery of insulin via the colon-targeted nanocomposite system of organoclay/glycol…
This study aimed to develop a ternary nanocomposite system of organoclay, glycol-chitosan, and Eudragit®S100 as an effective colon targeted drug delivery carrier to enhance the oral absorption of insulin. A nanocomplex of insulin and…
Orodispersible Tablets (ODTs) – Overcoming you main challenges
Orally Disintegrating Tablets (ODTs) are getting increasingly interesting delivery systems in the pharmaceutical and nutraceutical fields. They are an innovative way to handle the product lifecycle management, generate market…
Electrospun tri-layer nanodepots for sustained release of acyclovir
New strategies based on complex nanostructures for developing advanced functional materials providing sustained release of loaded active ingredients are highly desired in various scientific fields. In the present study, a new strategy was…
Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing
Remdesivir, an investigational broad-spectrum antiviral agent, has shown in vitro activity against SARS-CoV-2. To maximize direct delivery to the target site, the lungs, we aim to develop remdesivir as a dry powder for inhalation using thin…
Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of…
Hydrochlorothiazide (HCT) is widely used in pediatrics for hypertension management. Due to the lack of pediatric commercial forms, community or hospital pharmacies generally prepare HCT extemporaneous pediatric suspensions by dispersing in…
In Vitro Evaluation of Enteric-Coated HPMC Capsules – Effect of Formulation Factors on Product…
A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations…
Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel…
Many drug molecules that are currently in the market suffer from short half-life, poor absorption, low specificity, rapid degradation, and resistance development. The design and development of lipophilic prodrugs can provide numerous…
New EMA Guideline on use of pharmaceutical water
The guideline has been adapted based on the removal of the monograph for Highly Purified Water from the European Pharmacopoeia as well as changes in the European Pharmacopoeia including the revised monograph for Water for Injections…
Evaluation of an external lubrication system implemented in a compaction simulator
The internal blending of magnesium stearate is often associated with decreasing tensile strengths and longer disintegration and dissolution times. Therefore, external lubrication has gained interest in the pharmaceutical industry as these…
Suitability of phosphatidylcholine-based formulations for liquid filling in hard capsules
The current study aimed to evaluate whether phosphatidylcholine-based formulations have suitable properties for liquid filling in hard capsules. Liquid or semisolid formulations were obtained with Miglyol 812 (medium chain triglycerides) or…
Quantification of surface composition and surface structure of inhalation powders using TOF-SIMS
A multivariate TOF-SIMS methodology has been developed and applied to quantify surface composition and chemical distribution for dry powder blends. Surface properties are often critical to the behavior of powder formulations, especially in…
Tablet Quality-Prediction Model Using Quality Material Attributes: Toward Flexible Switching Between…
Purpose
The purpose of the study was to develop a model to predict the critical quality attribute (CQA) of tablets during continuous and batch manufacturing using only critical material attributes (CMAs).
Methods
Experiments were…
Strategies for High Concentration Drug Substance Manufacturing to Facilitate Subcutaneous…
In order to achieve the high protein concentrations required for subcutaneous administration of biologic therapeutics, numerous manufacturing process challenges are often encountered. From an operational perspective, high protein…
Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro…
The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact…
Micro and nanoscale technologies in oral drug delivery
Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that…
Boosting drug bioavailability in men but not women through the action of an excipient
Active pharmaceutical ingredients are routinely formulated with a range of excipients in the manufacture of drug products. Excipients are considered to be inert components of the formulations, although recent research has contested its…
Immobilization of β-CD on a Hyper-Crosslinked Polymer for the Enhanced Removal of Amines from…
In this paper, we adopted a simple and efficient strategy to prepare a β-cyclodextrin (β-CD)-modified hyper-crosslinked polymer (CDM-HCP). The structures and physicochemical properties of the as-synthesized polymer were also evaluated. It…
Hot-Melt Extrusion – Enabling Technologies from Dupont
"Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME…
Friday’s Top 5 by pharmaexcipients
The trending interest on how to improve API bioavailability goes on. The second week in a row the most viewed post on pharma excipients is now also ranking as the top post of the year. Let's see what is coming next!
Top posts of the week…
The activities of drug inactive ingredients on biological targets
Excipients, considered “inactive ingredients,” are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored.…
Characterization of Nanoparticles Using DSPE-PEG2000 and Soluplus
The aim of this study was to evaluate the characterized hydration method to prepare nanoparticles using Soluplus, a block copolymer with amphipathic properties, and distearoyl phosphatidyl ethanolamine (DSPE)-PEG2000 owing to particle size…
Tabletting Solid Dispersions of Bicalutamide Prepared Using Ball-milling or Supercritical Carbon…
The studies were aimed at formulating tablets containing bicalutamide-PVP K-29/32 solid dispersions and accessing the interrelationships between the properties of obtained binary systems in the form of powder and compacts. The effect of the…
Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of…
Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase. In recent years,…
Studies to predict the effect of pregelatinization on excipient property of maize and potato starch…
This study focuses on the effect of co-processing on physicochemical and drug release properties of starch mixtures. Different mixtures of native maize and potato starch were pregelatinized for different time intervals. The pregelatinized…
Development of a dental pocket drug delivery system based on temperature responsive polymer by the…
Controlled delivery systems are used to improve therapeutic efficacy and safety of drugs by delivering them at a rate dictated by the need of the physiologi- cal environment over a period of treatment to the site of action. A wide…
A review of regime maps for granulation
Granulation, a size enlargement technique to form agglomerates of primary particles, has proven to be effective in the production of solid dosage forms. Numerous granulation techniques can be applied, such as roll compaction, drum…
Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization
Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short…
3D printing for drug delivery and biomedical applications
Pharmaceutical product development is continuously witnessing innovations for the design of new delivery systems to improve the therapeutic efficacy of drugs. 3D-printing technology has been used to design customized personalized medication…
A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances…
Compaction and tableting properties of composite particles of microcrystalline cellulose and…
Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of…