Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Customized continuous solutions for oral solid dosage forms
With the technology platform MODCOS you can run several OSD processes: from powder to tablet, from powder to straw, from powder to stickpack, from powder to sachet, from powder to dry suspension and from powder to capsule. One solution for…
Biopharmaceutical implications of excipient variability on drug dissolution from immediate release…
Elucidating the impact of excipient variability on oral product performance in a biopharmaceutical perspective would be beneficial and allow excipient implementation on Quality by Design (QbD) approaches. The current study investigated the…
An Analytic Investigation of the Drug Formulation-Based Recalls in the USA: See More Beyond the…
High numbers of drug recalls persist despite the tremendous time and effort invested by pharmaceutical organizations and regulatory bodies such as the Food and Drug Administration (FDA) to ensure the quality of safe and effective medicines…
Compression behaviour of granules produced via twin-screw melt granulation: Effect of initial…
This study focuses on the impact of initial particle size on the tabletability and the deformation behaviour (i.e. plasticity) of granules produced by twin-screw melt granulation (TSMG). As model substances, three different grades of…
Semi-Phyto Universal Solubilizer (SPUS) for enhancing solubility and bio availability of Bioactive…
Aqueous Solubility of Bio actives plays a significant role in Drug, Biopharma, Food, Dietary and Cosmetic formulations. Poor solubility is one of the biggest hurdles in developing these formulations as well as desired therapeutic effect. It…
COVID-19 vaccine development and a potential nanomaterial path forward
The COVID-19 pandemic has infected millions of people with no clear signs of abatement owing to the high prevalence, long incubation period and lack of established treatments or vaccines. Vaccines are the most promising solution to mitigate…
Jet lag treatment with controlled release melatonin and caffeine
Multi-particulate Dome matrix with sustained-release melatonin and delayed-release caffeine was designed to restore jet lag sleep-wake cycle. The polymeric pellets were produced using extrusion-spheronization technique and fluid-bed coated…
Various Adsorbent Carriers used for Enhancing Dissolution Profile – A Review
In recent times, a large number of studies concerning the improvement of the dissolution rate of poorly water-soluble drugs are focused on the application of various porous materials as the drug carriers. These materials have attracted the…
Effect of particle size and deformation behaviour on water ingress into tablets
Drug release performance of tablets is often highly dependent on disintegration, and water ingress is typically the rate-limiting step of the disintegration process. Water ingress into tablets is known to be highly influenced by the…
Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules
Oral ingestion remains as the most convenient route of administration for the application of pharmaceuticals since it is non-invasive and does not require trained personnel to administer the drugs. Despite significant progress in novel oral…
In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules
Due to their relatively large molecular sizes and delicate nature, biologic drugs such as peptides, proteins, and antibodies often require high and repeated dosing, which can cause undesired side effects and physical discomfort in patients…
Friday’s Top 5 by pharmaexcipients
You have you missed the most popluar articles of this week? No worries you will find them here. It seems that the reaction on the question "How to improve API Bioavailability" is a major concern in the industry and reflects the evolution in…
Rectal Drug Delivery with Lipid Excipients
RECTAL DRUG DELIVERY
Lipid excipients can be used to formulate suppositories, creams, ointments and foams. Suppocire® is a well-established brand of semisynthetic hard fat bases comprising fatty acid esters. Their physicochemical…
Fabrication of Montelukast sodium loaded filaments and 3D printing transdermal patches onto…
The main objectives of this work were to develop and characterize new 3D printing filaments and print them directly onto a packaging material. Different blends of polymers were tested to achieve low-temperature printing filaments, which are…
Characterization of Controlled Release Microspheres Using FIB-SEM and Image-Based Release Prediction
For polymer-based controlled release drug products (e.g. microspheres and implants), active pharmaceutical ingredient distribution and microporosity inside the polymer matrix are critical for product performance, particularly drug release…
European Paediatric Formulation Initiative – 12th EuPFI Conference
It is our great pleasure to welcome you to the EuPFI 12th Annual Conference. The Scientific Committee, together with the EuPFI members, have been working diligently to prepare for the first virtual EuPFI conference. While we are…
Utilization of natural superdisintegrants in mouth dissolving tablet: A simplified review
Many drugs belong to BCS class-2 having poor solubility in water requires enhancement in solubility and dissolution rate for increasing its oral bioavailability; however, in many cases, immediate onset of action is required than…
Emerging trends in inhaled drug delivery
Ideally, inhaled therapy is driven by the needs of specific disease management. Lung biology interfaces with inhaler performance to allow optimal delivery of therapeutic agent for disease treatment. Inhalation aerosol products consist of…
Taste Masking of Pharmaceutical Formulations: Review on Technologies, Recent Trends and Patents
The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have unpleasant or obnoxious taste. Taste is one of the important parameters which governs patient compliance and also decides the success of a product in…
Edible polymers: An insight into its application in food, biomedicine and cosmetics
Edible polymers refer to the polymeric materials which can be consumed by human beings, animals or microorganisms without any noxious effects towards health. They are categorized into polysaccharides, proteins and lipids, and have gained…
Nanoliposomes in polymeric granules: Novel process strategy to produce stable and versatile delivery…
Liposomes, due to their mimetic cellular composition, are gaining great attention as release systems for lipophilic and hydrophilic molecules. However, liposomes can present a high tendency to degrade and aggregate into biological fluids…
Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and…
Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among…
Solubility and oral bioavailability enhancement: Gelucire® 48/16 pellets
Gelucire 48/16 is a non-ionic surfactant recommended for use in Lipid-Based Formulations (LBFs) to increase aqueous solubility and oral bioavailability of poorly soluble active ingredients. It is a PEG 32 ester lipid excipient comprising a…
Development of Low Dose Micro-tablets by High Shear Wet Granulation Process
Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU…
Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of…
The thermodynamically unstable nature of amorphous drugs has led to a persistent stability issue of amorphous solid dispersions (ASDs). Lately, microwave-induced in situ amorphization has been proposed as a promising solution to this…
In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the…
Smart polymers for colon targeted drug delivery systems: a review
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local…
How to improve API Bioavailability?
Today, poor solubility of New Chemical Entities is one of the most frequent and greatest challenges for formulators in the development of oral solid dosage forms. Improving API solubilization is thus of interest to increase bioavailability.…
Pfanstiehl Launches New cGMP-produced, Parenteral Grade Histidine and Histidine HCl For…
Pfanstiehl has launched high purity, low endotoxin, low metal L-Histidine and L-Histidine Hydrochloride Monohydrate and established a new quality standard for amino acids.
Amino acids are critical components utilized in bioprocessing for…
Tackling Coronavirus: The role of Roquette’s KLEPTOSE® HPβCD in the fight against COVID-19 –…
Hydroxypropyl β-cyclodextrin (HPβCD) has been shown to be effective as solubilizing and stabilizing agents in vaccines, monoclonal antibodies, and oral formulations.
Watch our expert video, featuring Pharma and BioPharma Scientists – Dr.…
The influence of porosity on tablet subdivision
A tablet microstructure, especially the porosity, is a crucial parameter that influences the mechanical properties. Herein, tablet subdivisions were studied as a function of tablet porosity. The tablets were manufactured in the presence of…
Mechanistic understanding of underperforming enteric coated products: Opportunities to add clinical…
Over the last 70 years several cases of in vivo failure of enteric coated (EC) formulations have been reported. The observed failures seem to be due to the slower than expected in vivo performance of EC products. Upon reaching the…
Pediatric dosage forms—challenges and recent developments: A critical review
Pediatric population is a diverse group comprising of different subgroups. The use of unlicensed and off-label medicines for treating children is widespread due to the non-availability of suitable dosage forms for this age group. Although…
A Comparison of Drug Release and Adsorption Under Supersaturating Conditions for Ordered Mesoporous…
Incomplete drug release from mesoporous silica systems has been observed in several studies. This work aims to increase understanding of this phenomenon by investigating the mechanism of drug-silica interactions and adsorption behaviour…