Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Screening of Pharmaceutical Polymers for Extrusion-Based Additive Manufacturing of Patient- Tailored…
The main objective of this work was to explore the potential of coupling hot-melt extrusion (HME) to Fused Filament Fabrication (FFF), also known as Extrusion-Based Additive Manufacturing (EBAM) or 3D Printing, in order to manufacture 3D…
5 solutions to common formulation challenges
1. Trouble finding a soluble DC filler/binder with pleasant taste and mouthfeel for non-GMO, lactose free formulations?
TRY EMDEX® - REQUEST A SAMPLE
EMDEX® is a directly compressible, water-soluble tablet binder and filler. Its…
Friday’s Top 5 by pharmaexcipients
You have you missed the most popluar articles of this week? No worries you will find them here. We also include the top phama excipient pages of last month and the most popular posts of the current year. This week even some changes in the…
Self-emulsifying excipient for solubility and oral bioavailability enhancement: Gelucire® 44/14
Gelucire® 44/14 is a non-ionic water dispersible surfactant recommended for use in lipid-based formulations to increase the aqueous solubility and oral bioavailability of poorly water soluble drugs.
A multi-component excipient…
Online Seminar Multiparticulates
Multiparticulates such as micropellets, pellets, granules and mini-tablets represent modern and innovative technology platforms. Multiparticulates can provide a number of advantages compared with larger-sized monolithic forms such as…
Essential oils: a review on their salient biological activities and major delivery strategies
Essential oils are volatile, complex products of plants as secondary metabolites and include terpenes and their oxygenated derivatives, such as alcohols, aldehydes, esters, ketones, phenols and oxides. In recent years, out of 3000 essential…
Most recent FDA approval for drugs using Vitamin E TPGS in the formulation
Ubrelvy™ December 2019 and Koselugro™ April 2020 are the most recent FDA approval of drug using Vitamin E TPGS in the formulation.
TPGS properties: Emulsifier - solubilizer of poorly soluble drugs - absorption enhancer - PgP inhibitor -…
Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney…
Recent studies reported adverse liver effects and intestinal tumor formation after oral exposure to titanium dioxide (TiO2). Other oral toxicological studies, however, observed no effects on liver and intestine, despite prolonged exposure…
3D printing: principles and pharmaceutical applications of selective laser sintering
Pharmaceutical three-dimensional (3D) printing is a modern fabrication process with the potential to create bespoke drug products of virtually any shape and size from a computer-aided design model. Selective laser sintering (SLS) 3D…
The prominence of the dosage form design to treat ocular diseases
The eye is susceptible to various diseases commonly difficult to treat. To overcome the barriers imposed by this organ for required drugs penetration, technological strategies have been implemented to ocular formulations. Among them are the…
Pharmacokinetic Investigation of Synthetic Cannabidiol Oral Formulations in Healthy Volunteers
Recent advances in the research of medicinal cannabis has placed the non-intoxicating cannabinoid cannabidiol (CBD) at the front of many investigations. The reasons behind this popularity is the compound’s therapeutic properties, alongside…
Interactive dashboard of COVID-19 drugs in world pharmacopeias
Through the World Health Organization, ten international pharmacopeias—including USP—have collaborated to publish this interactive dashboard of active pharmaceutical ingredients and monographs for existing generic drugs being investigated…
The extraordinary transformation of traditional Chinese medicine: processing with liquid excipients
The Chinese medicinal materials originate from animals, plants, or minerals must undergo appropriate treatment before use as decoction pieces. Processing of Chinese medicines with liquid excipients is a pharmaceutical technique that…
Fabrication of Polylactic Acid/Paclitaxel Nano Fibers by Electrospinning for Cancer Therapeutics
Background: Polylactic acid (PLA) is a thermoplastic and biodegradable polyester, largely derived from renewable resources such as corn starch, cassava starch and sugarcane. However, PLA is only soluble in a narrow range of solvents such as…
Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for…
Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance delivery of poorly water-soluble drugs, protect drugs against degradation and achieve modified release and drug targeting. This review focuses on the use of…
Performance tuning of particle engineered mannitol in dry powder inhalation formulations
Typically, smooth lactose particles are used as carrier in dry powder formulations for inhalation. Two classical approaches to improve their aerodynamic behaviour are the addition of fines (milled lactose) or magnesium stearate (MgSt).…
3D Printed Drug Delivery Systems Based on Natural Products
In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated…
Innovation in starter pellets – PharSQ® Spheres CM unique calcium-phosphate based starter…
Drug layering on starter pellets is a standard technology to achieve multiparticulate dosage forms. The most widely used are still sugar spheres / non-pareils but also neutral pellets made of microcrystalline cellulose such as Cellets are…
Conversion of indomethacin nanosuspensions into solid dosage forms via fluid bed granulation and…
Preparation of pharmaceutical nanosuspensions is a popular technique to increase the dissolution velocity of poorly water-soluble drugs. Subsequent drying into a compaction-ready powder or granule is a critical process due to possible…
An investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa plant, has been investigated for its medicinal properties including anti-psychotic, anti- emetic, anti-inflammatory, anxiolytic and anti- convulsant effects1,2.…
Dermal Pharmacokinetics of rivastigmine-loaded liposomes: an Ex vivo- in vivo correlation study
The aim of the present study was to develop a topical liposomal formulation as a transdermal delivery of rivastigmine for the treatment of Alzheimer disease as an alternative to the oral dosage form and to achieve smooth continuous drug…
Improved oral bioavailability and target delivery of 6-Shogaol via Vitamin E TPGS-modified…
6-Shogaol is one component of ginger, which has been described to possess various health-promoting effects including anticancer, anti-inflammatory, antioxidant and antiatherogenic. However, poor water solubility has limited the…
A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo…
We previously reported a novel method for the precise prediction of tablet properties (e.g., tensile strength (TS)) using a small number of experimental data. The key technique of this method is to compensate for the lack of experimental…
Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These barriers to oral…
Solid lipid nanocarriers diffuse effectively through mucus and enter intestinal cells – but where is…
Peptides are therapeutic molecules with high potential to treat a wide variety of diseases. They are large hydrophilic compounds for which absorption is limited by the intestinal epithelial border covered by mucus. This study aimed to…
Enteric-coated HPMC capsules: Comparison of enteric coatings and investigation of relationship…
Polymeric film coating of oral solid dosage forms may generate products that exhibit controlled release of active ingredients, physical and chemical protection of the ingredients from the external environment as well as taste masking…
Design and evaluation of bioenhanced oral tablets of Dunaliella salina microalgae for treatment of…
The application of Dunaliella salina (D. salina) microalgae in nutraceutical products is limited due to poor aqueous solubility and consequently low bioavailability of the existing β-carotene. The aim of the present study is the design of…
Friday’s Top 5 by pharmaexcipients
You have you missed the most popluar articles of this week? No worries you will find them here. We also include the top phama excipient pages of last month and the most popular posts of the current year.
Top posts of the week
#1 Kollidon®…
Alginate-based complex fibers with the Janus morphology for controlled release of co-delivered drugs
Hydrogels are soft materials consisting of a three-dimensional network of polymer chains. Over the years, hydrogels with different compositions have been developed as drug carriers for diverse biomedical applications, ranging from cancer…
High-Dose Methotrexate-Induced Idiopathic Intracranial Hypertension in Infant Acute Lymphoblastic…
A 7-month-old female patient with B-cell acute lymphoblastic leukemia (ALL) developed recurring anterior fontanelle bulging after completing both of her first and second courses of high-dose methotrexate (HD-MTX) induction. She did not,…
Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing…
Dissolution media based on bicarbonate buffers closely mimic the environment of intestinal fluids and thus improve in vitro in vivo correlation compared to phosphate buffers. Purging gases into the medium is used as a method to stabilise…
Using thin film freezing to minimize excipients in inhalable tacrolimus dry powder formulations
We investigated the feasibility of preparing high-potency tacrolimus dry powder for inhalation using thin film freezing (TFF). We found that using ultra-rapid freezing can increase drug loading up to 95% while maintaining good aerosol…
Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review
Background and objective: Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for…
Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally…
Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry…