Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology…
Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption…
Ready-To-Use: When Film Coating Becomes Easy, Fast & Reliable
What are the differences in film coating of solid oral dosage forms? What challenges do I face in developing, sourcing and preparing a film coating? Or have you ever wondered what the advantages of the ready-to-use film coating are?…
Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based…
Highlights
Novel hydrogel-forming microneedles were produced.
Their physicochemical properties were promising.
Methotrexate was successfully delivered in vitro and in vivo.
Methotrexate (MTX) is one of the mainstays of…
Cushioning Pellets based on Microcrystalline Cellulose – Crospovidone Blends for MUPS Tableting
Compaction of multiple-unit pellet system (MUPS) tablets has been extensively reported to be potentially challenging. Thus, there is a need for non-segregating cushioning agents to mitigate the deleterious effect of the compaction forces.…
Biologic excipients: Importance of clinical awareness of inactive ingredients
Due to the complexity and fragility of biological drug products, several challenges exist in their formulation development. Excipients are added to increase product stability, maintain tonicity, and facilitate drug delivery. The potential…
ADAPT Aspirin Dose Accuracy in PaediaTrics – a survey
ADAPT is a research project which enables researchers from the University of Birmingham to work with nurses and pharmacists involved in the manipulation of tablets to provide doses for children.
Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained…
Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene…
Smart polymeric micelles (PMs) are of practical interest as nanocarriers for the encapsulation and controlled release of hydrophobic drugs. Two hydrophobic drugs, naturally-based curcumin (Cur) and synthetic 5-fluorouracil (5-FU), were…
Tylopur® DG-4T – Special polymer for the preparation of hand sanitizer gel
A special Hypromellose type
Hand sanitizer gel is a hydroalcoholic gel formulated with a high level of alcohol. The Center for disease control and prevention (CDC) recommends a minimum of 60 percent alcohol…
TABLET COATING: Discover Your Options And Avoid All Process Issues
Have you missed this webcast on tablet coating by Seppic covering the following topics?
Which coatings without TiO2?
Which coatings to optimize process time?
Which coatings to protect your tablets?
Troubleshooting: How to…
Kollidon® The original PVP for solid oral dosage forms – overview
Kollidon is the original povidone for solid dosage forms. In this summary page you find the overview on the different types and information on the products including different manufacturing locations and product brochure.
The innovative…
Nanostructured lipid carriers as oral delivery systems for improving oral bioavailability of…
The aim of this study was to fabricate nanostructured lipid carriers, NLCs, of nintedanib (BIBF) to improve its oral bioavailability. Two types of NLCs loaded with BIBF (BIBF-NLCs-1 and BIBF-NLCs-2) were prepared by the melt-emulsification…
Stabilizing Enzymes within Polymersomes by Co-Encapsulation of Trehalose
Enzymes are essential biocatalysts and very attractive as therapeutics. However, their functionality is strictly related to their stability, which is significantly affected by the environmental changes occurring during their usage or…
Mucoadhesive bilayered buccal platform for antifungal drug delivery into the oral cavity
A drug delivery technology comprising a mucoadhesive bilayered buccally anchored tablet containing natamycin was developed. The concept was to anchor the tablet to the buccal tissue and allow controlled release of the drug through the…
Age-Appropriate Solid Oral Formulations for Pediatric Applications with a Focus on Multiparticulates…
This paper presents the output of a workshop held at the 11th Annual Conference of EuPFI (European Paediatric Formulation Initiative), in September 2019 in Malmo, Sweden, on the development of multiparticulates and minitablets as pediatric…
Impact of excipient choice on the aerodynamic performance of inhalable spray-freeze-dried powders
Spray-freeze-drying (SFD) is a process in which a solution is dispersed into a freezing medium and dried by sublimation, resulting in lyophilized powders with spherical particles. This study aims at screening and evaluating the impact of…
In Vitro-In Silico Evaluation of Apremilast Solid Dispersions Prepared via Corotating Twin Screw…
Highlights
• Solubility enhancement of Apremilast using Hot melt extrusion technology via Corotating Twin Screw Extruder.
• Theoretical and experimental determination of drug-polymer miscibility.
• Influence of Extruder…
Ciprofloxacin Loaded Nanostructured Lipid Carriers Incorporated into In-Situ Gels to Improve…
Bacterial endophthalmitis (BE) is a potentially sight-threatening inflammatory reaction of the intraocular fluids or tissues caused by bacteria. Ciprofloxacin (CIP) eye drops are prescribed as first-line therapy in BE. However, frequent…
Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus,…
Friday’s Top 5 by pharmaexcipients
You have you missed the most popluar articles of this week? No worries you will find them here. We also include the top phama excipient pages of last month and the most popular posts of the current year.
Top posts of the week
#1 StarLac®…
Developing HME-Based Drug Products Using Emerging Science: a Fast-Track Roadmap from Concept to…
This paper presents a rational workflow for developing enabling formulations, such as amorphous solid dispersions, via hot-melt extrusion in less than a year. First, our approach to an integrated product and process development framework is…
Effect of particle size on the pharmacokinetics and biodistribution of parenteral nanoemulsions
Highlights
Labeling by ACQ fluorophores enabled accurate bioimaging of nanoemulsions.
Nanoemulsions were cleared rapidly from the blood.
Nanoemulsions were mainly taken up by the liver after intravenous administration.…
Mechanodegradation of polymers: a limiting factor of mechanochemical activation in the production of…
In this study we report on the influence of mechanochemical activation on the chemical stability of amorphous solid dispersions made up of indomethacin and HPMC, PVP, PVPVA or Soluplus®. In agreement with our recently published work, all…
Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting:…
Adefovir dipivoxil (AD), a nucleoside reverse transcriptase inhibitor is effective against Hepatitis B virus. Its poor oral bioavailability leads to frequent administration causing severe adverse effects. Thereby the entrapment of AD within…
In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous…
Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been…
Sublingual tablets containing spray-dried carvedilol-loaded nanocapsules: development of an…
The aim of this study was to propose the use of spray-dried mucoadhesive carvedilol-loaded nanocapsules in the formulation of sublingual tablets. There is no previous report describing the preparation of tablets containing spray-dried…
Microneedle-Based Delivery: An Overview of Current Applications and Trends
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum,…
Formulation aspects of intravenous nanosuspensions
Intravenous (IV) route is preferred for rapid onset of action, avoiding first pass metabolism and achieving site specific delivery. Development of IV formulations for poorly water soluble drugs poses significant challenges. Formulation…
Leveraging Digital Assistance to Address Oral Solid Dosage Formulation Challenges
Did you miss the live webcast on “Leveraging Digital Assistance to Address Oral Solid Dosage Formulation Challenges”? No problem! Watch the recording and learn more about ZoomLab™. Register here
What can you expect from the webcast?…
Guaranteeing excipient quality by Gattefossé
For Gattefossé, quality is a strategic driver for progress which is fully integrated in every process we undertake, from research to product delivery to our customers.
Our quality policies are constantly upgraded to meet and even exceed…
Computer-Aided Discovery of New Solubility-Enhancing Drug Delivery System
The poor aqueous solubility of active pharmaceutical ingredients (APIs) places a limit on their therapeutic potential. Cyclodextrins (CDs) have been shown to improve the solubility of APIs, but the magnitude of the improvement depends on…
Technological Approaches for Improving Vaccination Compliance and Coverage
Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global…
Temperature and Solvent Facilitated Extrusion Based 3D Printing for Pharmaceuticals
On demand manufacturing of patient-specific oral doses provides significant advantages to patients and healthcare staff. Several 3D printing (3DP) technologies have been proposed as a potential digital alternative to conventional…
Effect of thickener on disintegration, dissolution and permeability of common drug products for…
Dysphagia is a very common problem suffered by elderly patients. The use of thickeners during administration in these patients helps to prevent difficulties with swallowing larger solid dosage forms. However, there are several indications…