Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Oral Fixed-Dose Combination Pharmaceutical Products: Industrial Manufacturing Versus Personalized 3D…
Fixed-dose combination (FDC) products containing at least two different active pharmaceutical ingredients are designed to treat more effectively different pathologies as they have demonstrated to enhance patient compliance. However, the…
Phospholipid-Based Delivery Systems – Phospholipids as Excipients in Advanced Veterinary Drugs
Advanced Veterinary Drugs by Using Phospholipids as Excipients
Phospholipids have been widely used as excipients in human medicine for decades. In veterinary medicine, too, there are various products on the market, which take advantage of…
Injectable Lipid-Based Depot Formulations: Where Do We Stand?
The remarkable number of new molecular entities approved per year as parenteral drugs, such as biologics and complex active pharmaceutical ingredients, calls for innovative and tunable drug delivery systems. Besides making these classes of…
Designing optimal formulations for hot-melt coating
Hot-melt coating (HMC) as a solvent-free technology grants faster and more economic coating processes with reduced risk of dissolving the drug during the process. Moreover, traditional coating equipment can be modified to enable the…
How To Formulate Medicine That Tastes Better
Recent trends show that patients and consumers want to take their medicine and nutritional supplements in a more comfortable and pleasant form.
If you’re looking to improve the palatability of your medicine, this webcast from beneo is…
StarLac® for Orally Disintegrating Tablets
Oral application of drugs is not only the most common way for systemic drug application, it is also patient’s route of choice. Oral formulations are – compared to injections or infusions – convenient and painless. As they do not require…
Polymeric Materials to Improve the Stability and Delivery of Insulin and Glucagon
Proteins and peptides have become an important class of therapeutics due to their high specificity and general biocompatibility. However, using proteins and peptides as drugs has several intrinsic challenges. These macromolecules are…
The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion…
Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors such as limited drug loading, poor stability,…
continuous twin screw granulation and fluid bed drying: a mechanistic scaling approach focusing…
This study provides the results of investigation on scaling approaches for three differently-sized continuous granulation lines, each consisting of a twin screw wet granulation process and a continuous fluid bed drying process. To check the…
Sensory aspects of acceptability of bitter-flavoured 7.5 mm film-coated tablets in adults, preschool…
There is great interest in demonstrating acceptability of solid oral formulations in paediatric populations. This study investigated the acceptability of small, 7.5 mm, bitter-flavoured, coated tablets in healthy children and adults. A…
Investigating the Potential of Transmucosal Delivery of Febuxostat from Oral Lyophilized Tablets…
Gout is the most familiar inflammatory arthritis condition caused by the elevation of uric acid in the bloodstream. Febuxostat (FBX) is the latest drug approved by the United States Food and Drug Administration (US FDA) for the treatment of…
Deep learning for continuous manufacturing of pharmaceutical solid dosage form
Continuous Manufacturing (CM) of pharmaceutical drug products is a new approach within the pharmaceutical industry. In the presented paper, a GMP continuous wet granulation line for production of solid dosage forms was investigated. The…
Friday’s Top 5 by pharmaexcipients
You have you missed the most popluar articles of this week? No worries you will find them here. We also include the top phama excipient pages of last month and the most popular posts of the current year.
Top posts of the week
#1 Amorphous…
Lipid Based Excipients for Modified Release
Modified- or sustained-release matrices are designed to release a drug slowly over an extended period of time. Formulations must be robust to ensure drug release over time and avoid dose-dumping. Lipid-based matrices are water-insoluble and…
Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery…
High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. This hampers their…
Enhanced Oral Bioavailability of Felodipine from Solid Lipid Nanoparticles Prepared Through…
Felodipine (FLD), a dihydropyridine calcium channel blocker with excellent antihypertensive effect, is poorly soluble and undergoes extensive hepatic metabolism, which lead to poor oral bioavailability (about 15%) and limit its clinic…
Solving the Insoluble with AFFINISOL™ HPMC
AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
More sophisticated drug…
Properties of κ-carrageenan aerogels prepared by using different dissolution media and its…
Highlights
Kappa-carrageenan aerogel materials were successfully prepared by dissolution into ionic liquids.
Dissolution into ionic liquids allows for a lower volume shrinkage with repercussions on the porosity of the aerogels.…
Copolymeric Micelles Overcome the Oral Delivery Challenges of Amphotericin B
Classified as a Biopharmaceutical Classification System (BCS) class IV drug, amphotericin B (AmB) has low aqueous solubility and low permeability leading to low oral bioavailability. To improve these limitations, this study investigated the…
Development of an Innovative, Carrier-Based Dry Powder Inhalation Formulation Containing Spray-Dried…
Most of the marketed dry powder inhalation (DPI) products are traditional, carrier-based formulations with low drug concentrations deposited in the lung. However, due to their advantageous properties, their development has become justified.…
Feasibility of Self-Emulsifying Drug Delivery System for Dissolution Enhancement of Indapamide
Purpose: Poorly water-soluble drugs when given orally experience limited dissolution due to their low solubility in aqueous solutions. This study aimed to investigate the dissolution enhancement using self-emulsifying drug delivery systems…
Excipients for Lubrication
During tablet and capsule production, lubricants are necessary to improve powder flow and reduce friction and adherence. Lubrication is a critical step since over- or underlubrication is responsible for many production and quality issues.…
Hierarchical mesoporous silica templated by the combination of fine emulsion and micelles
Highlights
• Mixed Organized Molecular Systems are formed by the mixture of Kolliphor and P123 templates.
• Hierarchical mesoporous silicas obtained by combining fine emulsion and micelles.
• Porosity features controlled by…
Studies on spectral characterization and solubility of hydroxypropyl β-cyclodextrin/iloperidone…
The antipsychotic drug Iloperidone (ILO) suffers from drawbacks of low solubility and poor bioavailability. In order to overcome such problems, we proposed to prepare binary and ternary complexes using kneading method and further compared…
Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs
Poor aqueous solubility is currently a prevalent issue in the development of small molecule pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate and bioavailability of Biopharmaceutics Classification…
QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic…
Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high first pass metabolism. Present study was aimed to…
Recent advances in polymeric drug delivery systems
Polymeric drug delivery systems have been achieved great development in the last two decades. Polymeric drug delivery has defined as a formulation or a device that enables the introduction of a therapeutic substance into the body.…
Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible…
A human panel study was performed to investigate the acceptability of orodispersible electrospun and solvent cast films. 50 healthy volunteers took two drug-free samples of polyvinyl alcohol films prepared by the two methods. On a 5-point…
Excipients for Solubility and Bioavailability Enhancement
Active pharmaceutical ingredients (APIs) exhibiting low aqueous solubility or poor intestinal permeability will be associated with poor or variable drug absorption. Lipid-based drug delivery (LBDD) has emerged as a successful approach to…
Amorphous Solid Dispersions in Early Stage of Formulation Development: Predicting Excipient…
Excipients play an important role in the formulation of dosage forms and can be used to improve the bioavailability of a drug through physical interactions that alter the rate of dissolution of a drug. The objective of this study was to…
A microcrystalline cellulose based drug-composite formulation strategy for developing low dose drug…
The uniformity of active pharmaceutical ingredient (API) is a main challenge associated with manufacturing low dose tablets. Here, we present a binder enhanced API-microcrystalline cellulose (BEAM) approach to address this challenge. In the…
Application and Functional Characterization of Kollicoat Smartseal 30D as a Solid Dispersion Carrier…
Many new chemical entities that are getting developed are poorly aqueous soluble and have low bioavailability. Out of many methods available for improving solubility, the solid dispersion by melt extrusion (ME) and spray drying (SP) is…
Overcoming Pharmaceutical Formulation Challenges – Webcasts by Fuji Chemicals
In drug development here is no one-size-fits-all approach which can be applied to allactive pharmaceutical ingredients (APIs). The best formulations and solutions depend on many characteristics, including the API characteristics, route of…
Impact of powder composition on processing-relevant properties of pharmaceutical materials
In this work, we studied the influence of powder composition on packing density and other processing-relevant properties of binary mixtures, including powder flowability. Binary mixtures of pharmaceutical powders with different particle…