Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Friday’s Top 5 by pharmaexcipients
You have you missed the most popluar articles of this week? No worries you will find them here. We also include the top phama excipient pages of last month and the most popular posts of the current year. This might give some hints which…
GranuLac® 80 a new grade of lactose monohydrate by Meggle
MEGGLE Excipients & Technology. MEGGLE has added GranuLac® 80 to its broad range of milled grade lactose monohydrate excipients.
GranuLac® 80
GranuLac® types consist of fine, sharp-edged lactose particles, having cohesive powder…
How COVID-19 is Changing Research Culture
LONDON, UK (4 June 2020) – Life Science Newswire – Digital Science, a leading technology company serving emergent needs across the research sector, has today released a report highlighting the global research landscape trends and cultural…
Hot melt extruded zein for controlled delivery of diclofenac sodium: Effect of drug loading and…
This study evaluates the potential use of zein as an excipient in hot-melt extrusion for controlled delivery of diclofenac sodium (DS). Mixtures of zein, polyethylene glycol and drug were hot melt extruded and cut into 2 mm extrudates.…
Hot Melt Coating of Amorphous Carvedilol
The use of amorphous drug delivery systems is an attractive approach to improve the bioavailability of low molecular weight drug candidates that suffer from poor aqueous solubility. However, the pharmaceutical performance of many neat…
Colon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods…
Advances in nutriology have suggested the colon as a superior site for nutrition absorption. Nutraceuticals, including phytochemicals, probiotics, etc., have received great attention owing to their health-promoting functionalities for…
Virtual Pharma Symposium by BASF June 16-18, 2020
Join experts from the pharmaceutical industry for a free 3-day webcast series. Each day a specific pharma-related topic will be discussed, and the audience will have the opportunity to ask questions directly to the experts. Each session has…
Application of Captisol® Technology to Enable the Formulation of Remdesivir in Treating COVID-19
James Pipkin, PhD, Vince Antle, PhD, and Rebecca Garcia-Fandiño, PhD, explain why more Captisol® than ever is required to meet Gilead’s bold goals of making remdesivir available to COVID-19 patients in the US and to hundreds of countries…
Formulation and evaluation of luteolin supersaturatable self-nanoemulsifying drug
The current investigation was aimed to enhance the solubility and oral bioavailability of luteolin by employing the supersaturable self-nanoemulsifying drug delivery system(S-SNEDDS). The formulation for SNEDDS consisted of caprylic/capric…
Analysis of available surface area can predict the long-term dissolution profile of tablets using…
Generally, since at least 6 months are usually needed for accelerated testing of tablet at 40°C/75% relative humidity (RH), it would be crucial important to predict the dissolution profiles during long-term storage period by using samples…
Polymer-Assisted Aripiprazole–Adipic Acid Cocrystals Produced by Hot Melt Extrusion Techniques
Pharmaceutical cocrystals offer a promising strategy to increase the solubility and dissolution rate of poorly soluble drugs. However, their manufacturing process requires a large quantity of solvents. The present study aimed to produce…
Webcast: Ready-to-use – When film coating becomes easy, fast & reliable – with…
Wednesday, 17 June 2020 - 03:00 PM CEST
What are the differences in film coating of solid oral dosage forms? What challenges do I face in developing, sourcing and preparing a film coating?
In our recorded webcast we will discuss…
Transformation of essential minerals into tablet formulation with enhanced stability
Essential minerals play a very important role in maintaining our physical well-being. In this work, essential minerals; copper sulphate, zinc sulphate, selenium dioxide, chromium picolinate, sodium molybdate and potassium iodide were…
Advanced formulations “supersaturating drug delivery systems” – A video by UNGAP
An UNGAP video further focussing on specific intraluminal behavior of advanced formulations such as supersaturating drug delivery systems, nanoparticles, and lipid-based and controlled release formulations.
About
Oral…
Fine grade engineered microcrystalline cellulose excipients for direct compaction: Assessing…
Recent work showed that contrary to conventional wisdom, fine surface engineered excipients outperform their larger counterparts in blends of highly loaded blends of cohesive drug powders in terms of their packing, flowability and tablet…
Development and Characterization of Liquisolid Tablets Based on Mesoporous Clays or Silicas for…
The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of…
Top drugs and pharmaceutical companies of 2019 by revenue
By Team PharmaCompass
Acquisitions and spin-offs dominated headlines in 2019 and the tone was set very early with Bristol-Myers Squibb acquiring New Jersey-based cancer drug company Celgene in a US$ 74 billion deal announced on January…
From powder to tablets: Investigation of residence time distributions in a continuous manufacturing…
The essence of Continuous Manufacturing (CM) resides in the fact that continuous process units are directly connected to each other forming a continuous process train. The thorough understanding of material flow in this train based on…
Hypromellose – A traditional pharmaceutical excipient with modern applications in oral and…
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights…
Xanthan Gum – Round table by USP to modernize the monograph
USP is interested in hosting a Virtual Round Table concerning the modernization of this monograph. We encourage all to participate to help us ensure the quality of medicines for our global patients!
If your company manufactures Xanthan…
Fabrication of modified-release custom-designed ciprofloxacin tablets via fused deposition modeling…
Aim: The aim of the present work was to fabricate customized tablets of ciprofloxacin hydrochloride through 3D printing for optimized dosing.
Materials & methods: A hot melt extrusion technique was employed to produce polyvinyl…
Effect of common excipients on intestinal drug absorption in Wistar rats
The aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and rhodamine (as P-Glycoprotein substrate). Apparent permeability was measured by in…
Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic…
Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun mat…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 Amorphous Solid Dispersions - Ask a specialist
#2 Viscosity of API/fatty acid suspensions: Pitfalls during analysis
#3…
Implications of Solid Lipid Nanoparticles of Ganoderic Acid for the Treatment and Management of…
Purpose
The present work describes the systematic development of ganoderic acid (GA)–loaded solid lipid nanoparticles (SLNs) for the treatment of hepatocellular carcinoma (HCC).
Methods
A full factorial design was employed for…
Self-Generating nano-emulsifying technology for alternatively-routed, bioavailability enhanced…
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of a hydrophobic or poorly-water soluble drug. The methodology…
Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches
In its 33 years, ADDR has published regularly on the potential of oral delivery of biologics especially peptides and proteins. In the intervening period, analysis of the preclinical and clinical trial failures of many purported platform…
Nanostructured lipid carriers loaded with Halobetasol propionate for topical treatment of…
The aim of this research was the development and characterization of three gel dosage forms of Halobetasol propionate loaded lipid nanoparticles (HB-NLC) for the treatment of inflammatory skin diseases. A Pluronic gel (Pl-HB-NLC), a…
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution…
The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the…
Can 3D printing of oral drugs help fight the current COVID-19 pandemic (and similar crisis in the…
The ongoing COVID-19 crisis has highlighted the importance of a robust drug supply chain which can be quickly and flexibly ramped up to produce life-saving drug treatments. 3D printing (3DP) of oral solid dosage forms (OSDF) could be…
Captisol®: an efficient carrier and solubilizing agent for essential oils and their components
Essential oils (EOs) and their individual components have several biological properties and are used in cosmetics, food and pharmaceutical industries. However, their application still presents a challenge owing mainly to their volatility…
Exploring the feasibility of biopolymers as potential carriers in the formulation of amorphous solid…
Adequate aqueous solubility of active pharmaceutical ingredients (APIs) is a crucial factor for therapeutic effectiveness. Today, more than fifty percent of the new potential APIs are exhibiting poor aqueous solubility/dissolution rate,…
EXCiPACT Pharmaceutical Excipients Certification Scheme – Free-to-Attend Seminar, DQS Office,…
Brussels, 02 June 2020
EXCiPACT asbl is pleased to announce details of their free-to-attend seminar to be held in Frankfurt at DQS offices on Wednesday, 25 November 2020 with the following program:
09.45h Registration/Coffee
10.15h…
Temperature: an overlooked factor in tablet disintegration
Disintegration is the first event in the bioavailability cascade after the ingestion of immediate release tablets. Although the influence of various physico-chemical parameters of media on tablet disintegration has been investigated in…