Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Co-Processed Product Selection Guide – Avicel®
Co-processed excipients (CPEs) provide functional synergy with the convenience of reduced testing and scale-up. When manufactured under tightly controlled conditions, CPEs deliver consistent, cost-effective performance and are particularly…
Percutaneous delivery of levetiracetam as an alternative to topical nonsteroidal anti-inflammatory…
The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as…
Residual film formation after emulsion application: understanding the role and fate of excipients on…
This study focuses on the fate of excipients contained in topical emulsions once applied on the skin. The aim was thus to develop a methodology to characterize the residue left on the skin shortly after emulsion application. To this end,…
Central Composite Design-Based Optimization of Lopinavir Vitamin E-TPGS Micelle: In Vitro…
Highlights
• Lopinavir was successfully loaded into Vitamin E-TPGS micelles.
• Micelle were prepared by thin film hydration technique.
• Polymer concentration and rotational speed are key parameters in micelle preparation.…
Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation…
The effect of a wide variety of binders on the quality of granules produced via continuous twin screw wet granulation was studied. Anhydrous dicalcium phosphate was used as poorly soluble filler and was granulated applying dry or wet…
Converting a batch based high-shear granulation process to a continuous dry granulation process
When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies which can be adopted. Theoretically, the most straightforward way would be to…
Erodible Coatings Based on HPMC and Cellulase for Oral Time-Controlled Release of Drugs
Oral drug delivery systems for time-controlled release, intended for chronotherapy or colon targeting, are often in the form of coated dosage forms provided with swellable/soluble hydrophilic polymer coatings. The latter are responsible for…
Design and development of polymethylmethacrylate-grafted gellan gum (PMMA-g-GG)-based pH-sensitive…
The objective of the present study was to develop a pH-sensitive drug delivery system by using polymethylmethacrylate-grafted gellan gum (PMMA-g-GG). PMMA-g-GG was synthesized by free radical polymerization reaction by using redox initiator…
Viscosity of API/fatty acid suspensions: Pitfalls during analysis
This article describes how to obtain reliable data during rheological analysis of active pharmaceutical ingredient/fatty acid suspensions. These materials are specifically used for prilling, an innovative pharmaceutical technique for the…
XStraw®: Easy way of administering correctly dosed medication
XStraw® is the name of a new dosage form using a drinking straw. The straw is pre-filled with a drug and enables a more comfortable intake for children and patients having diffculty swallowing.
With XStraw®, the intake is based on a…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 Cyclodextrin complexation studies as the first step for repurposing of chlorpromazine
#2 Design (QbD) Approach to Match…
Parteck® Coat: When coating runs smoothly – Reduce coating time with optimized particle…
Parteck® COAT Excipient - Start rapidly, coat flexibly.
It can be a challenge to find the right coating for your formulation, and it can be even more frustrating when your workflow is restrained due to slow processing times. With Parteck®…
A shear cell study on oral and inhalation grade lactose powders
Shear cell tests have been conducted on twenty different lactose powders, most of which commercially available for oral or inhalation purposes, spanning a wide range of particle sizes, particle morphologies, production processes. The aims…
In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet…
Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid occurs. Wetting is a critical step to allow granule growth and consolidation, but also to ensure uniform active…
Ultrathin coating of particles in fluidized bed using submicron droplet aerosol
In this work, we demonstrate that particles can be coated in a fluidized bed with coating solution provided by a novel aerosol generator. Aerosol droplets are smaller than 1 µm in volume-based diameter, hence they are very much smaller than…
Stimulatory Effects of Soluplus® on Flufenamic Acid β-Cyclodextrin Supramolecular Complex:…
The present study demonstrates the solubility and dissolution of flufenamic acid (FLF)/β-cyclodextrin (β-CD)/Soluplus® supramolecular ternary inclusion complex. The binary and ternary inclusion complexes were prepared using solvent…
Sustained release – made from nature with Tylopur Xtend Nutra®
XTENDED RELEASE OF ACTIVE INGREDIENTS FOR NUTRACEUTICAL & NUTRITIONAL APPLICATIONS
Tylopur Xtend Nutra® is a plant derived cellulose-based ingredient produced by Shin-Etsu. It is specifically developed for nutraceutical and…
Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets
This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen…
Sulfobutylether-β-cyclodextrin – Captisol®
This review presents the early history, the motivation, the research and some of the backstories behind the discovery and development of sulfobutylether-β-cyclodextrin as a novel parenterally safe solubilizer and stabilizer. A specific…
Optimization and evaluation of encapsulated brimonidine tartrate-loaded nanoparticles incorporation…
Highlights:
PCL-TPGS nanoparticles of BRT were prepared using nanoprecipitation method.
Drug nanoparticles were incorporated into thermosensitive in situ gel systems which provide sustained release than commercial eye drops.…
Zein-based micro- and nano-constructs and biologically therapeutic cues with multi-functionalities…
The selection of polymer with biologically tunable functionalities is a key point for its suitable application. Natural polymers (especially proteins) are preferred over synthetic counterparts, in this regard. Zein is a natural protein…
New generation of supramolecular mixtures: Characterization and solubilization studies
In this work, a series of novel low melting mixtures (LMM) based on cyclodextrins (CD) and levulinic acid and inspired by the deep eutectic solvents (DES), were prepared. These supramolecular mixtures are the first reported CD-based…
Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment
Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop…
Enhanced Intestinal Absorption of Insulin by Capryol 90
Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration. However, the effects of…
Free Whitepaper – Lactose properties in 3D powder bed printing
The whitepaper shows results of tested 20 lactose grades in 3D powder bed printing. The primary objective of this study was to select lactose with sufficient flow, wetting and binding to be used effectively in the powder bed 3D printing of…
Artificial neural networks applied to quality-by-design: From formulation development to clinical…
Quality-by-Design (QbD) is a methodology used to build quality into products and is characterized by a well-defined roadmap. In this study, the application of Artificial Neural Networks (ANNs) in the QbD-based development of a test drug…
Quality by Design (QbD) Approach to Match Tablet Glossiness
A quality by design (QbD) approach was used for a PVA-based coating to develop a “look-alike” placebo tablet, which can match the glossiness (shine) of an innovator tablet. Critical coating parameters such as exhaust temperature, drying…
Moisture sorption and desorption properties of gelatin, HPMC and pullulan hard capsules
The moisture sorption and desorption properties of hard capsules have a great influence on the quality of capsule products. However, studies on them have rarely been reported. Herein, we studied the moisture sorption and desorption…
Quality by Design thinking in the development of long-acting injectable PLGA/PLA-based microspheres…
Adopting the Quality by Design (QbD) approach in the drug development process has transformed from ‘nice-to-do’ into a crucial and required part of the development, ensuring the quality of pharmaceutical products throughout their whole life…
Metformin Hydrochloride- and Glyburide-Containing Orally Disintegrating Tablets
Diabetes is characterized by chronic hyperglycemia. Although metformin hydrochloride (MHCl)- and glyburide (GLB)-containing conventional tablets are available in the market and used to treat diabetes, orally disintegrating tablets (ODTs)…
Real-time monitoring of multi-layered film coating processes using Raman spectroscopy
Raman spectroscopy was used as an in-line PAT tool to predict the applied coating mass of three different coating layers on caffeine cores. The different coating suspensions contained titanium dioxide in the anatase and rutile modification…
Influence of the Porosity of Cushioning Excipients on the Compaction of Coated Multi-Particulates
The compaction of multiple unit-pellet system (MUPS) tablets poses considerable challenges due to potential compaction-induced damage to the functional polymer coat and segregation of pellets from other excipients during the tableting…
Impact of Magnesium Stearate Presence and Variability on Drug Apparent Solubility Based on Drug…
Excipients are major components of oral solid dosage forms, and changes in their critical material attributes (excipient variability) and/or amount (excipient variation) in pharmaceutical formulations may present a challenge for product…
Self-emulsifying drug delivery systems: About the fate of hydrophobic ion pairs on a phospholipid…
Purpose
To investigate the fate of hydrophobic ion pairs (HIPs) and self-emulsifying drug delivery systems (SEDDS) containing HIPs on a phospholipid bilayer.
Methods
HIPs of fluorescein (FL) were formed using the lipophilic…