Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Nanocomposite Cryogel Carriers from 2-Hydroxyethyl Cellulose Network and Cannabidiol-Loaded…
In this contribution, we report the development of original nanocomposite cryogels for sustained topical delivery of hydrophobic natural active substances such as cannabidiol (CBD). The cryogels were fabricated by a method involving…
3D-printed microfluidic chip for the preparation of glycyrrhetinic acid-loaded ethanolic liposomes
18-α-Glycyrrhetinic acid (GA) is a bioactive compound extracted from licorice that exhibits many biological and pharmacological effects such as anti-inflammatory and antioxidant activities on the skin. However, its lipophilic nature results…
Functionality of disintegrants with different mechanisms after roll compaction
The aim of this study was to investigate the functionality of two disintegrants (crospovidone and croscarmellose sodium) in tablet formulations processed via roll compaction and subsequent tableting. The influence of different fillers and…
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol…
Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention
#2 Curcumin-loaded solid self-emulsifying drug…
Ac-Di-Sol® SD-711 Superdisintegrant – Whitepaper
DuPont’s portfolio of Pharma solutions and formulation and process expertise drive improved product, process and cost performance based on real-world experience. Using Ac-Di-Sol® SD-711 at lower levels and earlier in the development process…
How to prepare a ready-to-use film coating suspension – a Video explanation
Here is BIOGRUNDs step-by-step guide how to prepare a suspension.
Equipment & Material
Equipment: propeller stirrer, beaker
Material: Water, AquaPolish
Here is a simple calculation for a suspension with for example 20 %…
Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of…
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system under investigation for their aptitude to enhance the oral bioavailability of poorly water-soluble drugs. The cholesterol-lowering agent, simvastatin…
Rheological & Suspending Properties of Commonly Used Oral Suspending Vehicles
Little is documented about the rheology of commonly oral used suspending vehicles (which include everything from water through commercial suspending agents to semi-solid foods such as yoghurt which are often used in the administration of…
Characterization of lipid composition and diffusivity in OLA generated vesicles
Giant Unilamellar Vesicles (GUVs) are a versatile tool in many branches of science, including biophysics and synthetic biology. Octanol-Assisted Liposome Assembly (OLA), a recently developed microfluidic technique enables the production and…
Electrospinning of natural polymers for the production of nanofibres for wound healing applications
Wound healing is a highly regulated process composed of four overlapping phases: (1) coagulation/haemostasis, (2) inflammation, (3) proliferation and (4) remodelling. Comorbidities such as advanced age, diabetes and obesity can impair…
Quantification of tablet sensitivity to a stress concentration: Generalization of Hiestand’s…
Sensitivity to a stress concentration is important for the development of pharmaceutical tablets as it is related to defects like capping. The Brittle Fracture Index (BFI) was introduced by Hiestand et al. to test this sensitivity.…
SeDeM-ODT Expert System: A Solution to Challenges in Characterization of Pharmaceutical Powders and…
In the field of pharmaceutical sciences, material characterization has been a focus of research as properties of the powder ingredients govern characteristics of the finished dosage form. It has been a tedious and time-consuming job to…
Nanoencapsulation approaches for oral delivery of vitamin A
Vitamin A is essential to human health. Encapsulation in lipid nanoparticles was used to overcome vitamin A poor water solubility in beverages. This work aimed to develop and characterize lipid nanoparticles, containing vitamin A, for food…
Tailored granule properties using 3D printed screw geometries in twin screw granulation
Twin screw granulation is becoming increasingly relevant due to its compact size, continuous and robust mode of operation, customizable design, and flexible production capacity. This work describes the experimental study undertaken to…
Current update on nanoplatforms as therapeutic and diagnostic tools: a review for the materials used…
In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held of great attention. Up to date, several approaches have been employed in order to develop smart…
The Ouzo effect: A tool to elaborate high-payload nanocapsules
Higlights
• The Ouzo effect enables high loading of Hybridosomes (hybrid capsule).
• The cargo is nanoprecipitated within the core of Hybridosomes.
• The cargo is released to the body while the capsule is captured by the…
Learn more about: Qualit-E – Securely Upload And Share Quality Documents
Do you get more inquiries about quality documents than you sell raw materials? Is the rule 1 kg raw material = 1 kg documents true to you?
Then let us show you how you can easily reduce this workload and start with Qualit-e Cloud:
See our…
The Stabilizing Excipients in Dry State Therapeutic Phage Formulation
Phage therapy has gained prominence due to the increasing pathogenicity of “super bugs” and the rise of their multidrug resistance to conventional antibiotics. Dry state formulation of therapeutic phage is attractive to improve their…
Formation of nanoparticles for the oral delivery of small molecules by Flash Nanoprecipitation
Nanoparticles have shown considerable potential in many biological applications including drug delivery, bio-imaging, and medical diagnostics. Specifically, the development of nanoparticle-based drug formulations holds opportunities to…
Rifampin and Cis-2-Decenoic Acid Co-entrapment in Solid Lipid Nanoparticles as an Efficient…
Purpose
This study was performed to explore the physicochemical and anti-biofilm properties of rifampin (Rif) and cis-2-decenoic acid (C2DA) co-entrapped in solid lipid nanoparticles, Rif-C2DA-SLN, against staphylococcal biofilm.
Methods…
Learn more about Market Trends & Clean Label Solutions For Solid Oral Dosage Forms
Want to discover what drives the dietary supplement consumer today and in future? What does the industry has to do to satisfy the consumer needs? What does Clean Label mean for manufacturers of solid oral dosage forms?
See our recording…
Influence of Oil Composition on the Transformation, Bioaccessibility, and Intestinal Absorption of…
The influences of liquid medium chain triglycerides (MCT) and solid glyceryl tristearate (GTS) contents in the lipid matrix of nanostructured lipid carriers (NLCs) on their delivering capacities for Cur were investigated herein by simulated…
Convert oily actives (CBD oil) into flowable and compressible powder
FujiSil™ is a highly porous silica material. It allows you to convert oily actives into flowable and compressible powder. It is ideal for formulations with CBD oil.
Very high adsorption capability
Turn your oily active into a…
Sugar-free medicated high-boiled lozenges with long shelf-life
BENEO’S galenIQ makes sugar-free medicated high-boiled lozenges with long shelf-life
When it comes to producing medicated hard-boiled lozenges, then galenIQ™ 900, the pharmaceutical excipient grade of BENEO’s isomalt, is the number one…
Characterization of ternary amorphous solid dispersion containing hypromellose phthalate and…
Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation or residual crystallinity formation. This caveat may be addressed by optimizing formulations and…
Compression-Induced Phase Transitions of Bicalutamide
The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improves the dissolution characteristics of poorly soluble drugs. Although they provide an improved absorption after oral administration, the…
Easy to Swallow “Instant” Jelly Formulations for Sustained Release Gliclazide Delivery
It is a challenge to safely administer sustained release medicines to patients with dysphagia. Sustained release tablets must not be crushed and multiparticulates with large particle sizes cause gritiness reducing patient acceptability. The…
The core benefits of Neusilin® as an excipient – Oil adsorption
Neusilin® is a Multi-problem solver. It solves common problems associated with tableting by facilitating improved and consistent flow of powder mix, providing optimum tablet hardness at low compression forces, protecting the active…
Design of ocular drug delivery platforms and in vitro – in vivo evaluation of riboflavin to…
Highlights
• Riboflavin salt showed higher nanoparticle drug loading than riboflavin base.
• Riboflavin salt leads to higher corneal drug transport than riboflavin base.
• Transcutol p (permeation enhancer) increased the…
Development and characterization of curcumin-loaded solid self-emulsifying drug delivery system…
Highlights
• Soluplus® could be used as a carrier for the entrapment of SEDDS.
• Spray drying is efficient for the preparation of Solid SEDDS with Soluplus®.
• Solid SEDDS in Soluplus® exhibit comparable flow as Neusilin®…
Simultaneous Investigation of the Liquid Transport and Swelling Performance during Tablet…
Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the…
New Orodispersible Mini Tablets of Enalapril Maleate by Direct Compression for Pediatric Patients
BACKGROUND:
In many countries, the hypertension in the pediatric population is considered an important risk of mortality and morbidity. In this sense, it is important to design and develop new pharmaceutical forms for pediatric patients…
Quality Risk Management and Quality by Design for the Development of Diclofenac Sodium…
The aim of the present study was to evaluate the development of an intra-articular nonsteroidal anti-inflammatory drug gelatin microsphere formulation based on quality risk management and quality by design approaches. Specifically, after…