Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention
#2 A novel hydroxypropyl methylcellulose…
Fully inkjet‐printed glucose assay fabricated on highly porous pigment coating
A simple paper-based microfluidic device, fabricated on a highly porous coating consisting of functionalised calcium carbonate (FCC) pigment and a microfibrillated cellulose (MFC) and/or polyvinyl alcohol (PVOH) binder, was developed for…
Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica…
Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent…
Drug Delivery Strategies for Poorly Water-Soluble Silymarin
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, is gaining an increasingly widespread clinical consensus as a natural remedy in the treatment of numerous…
Faster Disintegration, at Lower Use of Disintegrant
The superdisintegrant Ac-Di-Sol® provides excellent water uptake and rapid swelling properties, resulting in a fast disintegration and dissolution at low use levels (1-2%). Check the video to learn more:
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Acceptability of an orodispersible film compared to syrup in neonates and infants: A randomized…
Objectives
Reliable pediatric pharmacotherapy in all age groups requires the availability of age-appropriate drug administration. Orodispersible films (ODF) are a promising pediatric oral dosage form. ODFs would meet relevant targets:…
A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery
The aim of the present study was the development of a novel gellan gum derivative exhibiting mucoadhesive properties for nasal application.
Accomplishing this, amino groups have been introduced to the polymeric backbone. The resulting…
The effect of PLGA molecular weight differences on risperidone release from microspheres
The objective of the present study was to investigate the effect of molecular weight differences of poly (lactic-co-glycolic acid) (PLGA) on the in vitro release profile of risperidone microspheres. Four different PLGA molecular weights…
Enteric polymer-based microspheres by spray-drying for colonic delivery of Lactobacillus rhamnosus…
Antibiotics are well-known disruptive elements of the intestinal microbiota and antibiotic-associated diarrhea appeared as the most common complication related with post-antibiotic dysbiosis. Lactobacillus rhamnosus GG (LGG) strain is very…
Selective Laser Sintering 3D Printing – An Overview of the Technology and Pharmaceutical…
Food and Drug Administration (FDA) has approved a drug product (Spritam®) and many medical devices manufactured by 3-dimensional printing (3DP) processes for human use. There is immense potential to print personalized medicines using 3DP.…
Exploration of Fulvic acid as a functional excipient in line with regulatory requirement
Fulvic acid, a humic substance often considered as a geopolymer, extracted from different natural resources like Shilajit, Peat, dissolved organic matters, etc. There are several reports of its pharmacological properties and its potential…
Scintigraphic evaluation of the in vivo performance of dry-coated delayed-release tablets in humans
We characterized the gastrointestinal (GI) transit and drug release characteristics of dry-coated delayed-release tablets under both prandial states in humans using a gamma scintigraphy approach. We also estimated the onset time of drug…
Peptides for oral administration
The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist…
Encapsulation of Ferulic Acid in Lipid Nanoparticles as Antioxidant for Skin: Mechanistic…
Ferulic acid, though used in formulations of skin-care and cosmetic products, suffers from the problems of poor stability and low aqueous solubility. Encapsulation into nanoparticle can be a viable route to overcome these inherent problems.…
A Novel Natural GRAS-Grade Enteric Coating for Pharmaceutical and Nutraceutical products
In this study, enteric coatings based exclusively on naturally occurring ingredients were reported. Alginate (Alg) and pectin (Pec) blends with or without naturally occurring glyceride, glycerol monostearate (GMS), were initially used to…
Cyclodextrin complexation studies as the first step for repurposing of chlorpromazine
The antipsychotic drug chlorpromazine (CPZ) has potential for the treatment of acute myeloid leukemia, if central nervous system side-effects resulting from its passage through the blood–brain barrier can be prevented. A robust drug…
Modified cyclodextrins as broad-spectrum antivirals
Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We…
Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial…
Antibiotic resistance has become a global crisis, driving the exploration for novel antibiotics and novel treatment approaches. Among these research efforts two classes of antibiotics, bicyclic nitroimidazoles and antimicrobial peptides,…
What’s new in the field of phospholipid vesicular nanocarriers for skin drug delivery
Over the last three decades, research in the field of phospholipid nanocarriers as tools to improve dermal and transdermal drug delivery has grown substantially. In particular, liposomes have been the target of studies aimed at…
Spray drying of API nanosuspensions: Importance of drying temperature, type and content of matrix…
Active pharmaceutical ingredient (API) nanosuspensions from naproxen (Nap) and itraconazole (Itra) stabilized with Kollidon®VA64 (KVA) and sodium dodecyl sulfate (SDS) were produced in two different size classes each by wet media milling.…
Co-processed Excipient for Direct Compression Designed for Orally Disintegrating Tablets
Developing orally disintegrating tablets (ODTs) is a worldwide trend. In recent years, new excipients and excipient blends have enabled manufacturers to produce ODTs using conventional equipment, i.e., blenders and tablet presses. One such…
Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention
A new strain of coronavirus (2019-nCoV) started to emerge in late December 2019 from Wuhan, the capital of Hubei Province in central China, which is a city with a population of 11 million. The pneumonia- like illness, which has spread…
Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention
A new strain of coronavirus (2019-nCoV) started to emerge in late December 2019 from Wuhan, the capital of Hubei Province in central China, which is a city with a population of 11 million. The pneumonia- like illness, which has spread…
Vaccine Excipient Summary
Excipients Included in U.S. Vaccines, by Vaccine
In addition to weakened or killed disease antigens (viruses or bacteria), vaccines contain very small amounts of other ingredients – excipients.
Some excipients are added to a…
Comparison of induction methods for supersaturation: Amorphous dissolution versus solvent shift
Simple solvent shift is often used to induce supersaturation and investigate precipitation kinetics in early drug development as a substitute for amorphous dissolution. This study develops and compares a small-scale non-sink amorphous…
Full-Spectrum Cannabis Extract Microdepots Support Controlled Release of Multiple Phytocannabinoids…
The therapeutic effect of the Cannabis plant largely depends on the presence and specific ratio of a spectrum of phytocannabinoids. While prescription of medicinal Cannabis for various conditions constantly grows, its consumption is mostly…
Top 10 Trends in Excipients for the Nutraceutical Oral Solid Dosage Forms Market
The overall nutraceuticals market is growing at a higher rate than pharmaceuticals. However, the growth in the nutraceutical market does not entirely translate to excipients market growth for nutraceutical OSDFs. The reason: Excipients are…
Characterization of a novel hydroxypropyl methylcellulose (HPMC) direct compression grade excipient…
Controlled release tablets are important dosage forms enabling a slower release of the drug and better pharmacokinetics for some drugs and hydrophilic matrix tablets utilizing hydroxypropyl methylcellulose (HPMC) are one of the most common…
Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status,…
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell.…
A physiologically-based drug absorption modeling for orally disintegrating tablets
The aim of this research was to simulate oral pharmacokinetic (PK) profiles of atorvastatin from orally disintegrating tablets (ODTs) dosed without water ingestion in fasted humans. The in vitro dissolution profiles of three different…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 Dissolution is beautiful – see the wonders of dissolution with new eyes
#2 Top 200 Drugs 2019 – The Poster
#3 OPTICORE™,…
Lipid Nanoarchitectonics for Natural Products Delivery in Cancer Therapy
Therapeutic applications of natural products have been noteworthy. A large sum of the population thrives on these products for countering multiple diseases and ailments. However, poor pharmacokinetic and pharmacodynamic profile of these…
Compaction behavior of isomalt after roll compaction
Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow taste masking, the low glycemic and insulinemic response (Petzoldt, 1982), and the ability to be compacted directly. With…
Development of chitosan-coated agar-gelatin particles for probiotic delivery and targeted release in…
This study reports the development of a novel and simple formulation for probiotic delivery using chitosan-coated agar-gelatin gel particles. This methodology involves the production of agar-gelatin particles by thermally treating a mixture…