The benefits of lactose as an excipient
Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of using lactose as an excipient.
Medicines are…
Development of chitosan-coated agar-gelatin particles for probiotic delivery and targeted release in…
This study reports the development of a novel and simple formulation for probiotic delivery using chitosan-coated agar-gelatin gel particles. This methodology involves the production of agar-gelatin particles by thermally treating a mixture…
Dissolving Microneedles for Rapid and Painless Local Anesthesia
Microneedles are emerging drug delivery methods for painless treatment. The current study tested dissolving microneedles containing lidocaine (Li-DMN) for use in local anesthesia. An Li-DMN patch was fabricated by centrifugal lithography…
In-Situ Forming Vesicles for the Improvement of the Bioavailability of Fexofenadine HCl
Drug absorption from the gastrointestinal tract (GIT) is one of the major problems affecting the bioavailability of orally absorbed drugs. This work aims to enhance Fexofenadine HCl oral bioavailability in vivo, the drug used for allergic…
Mixed micelles of TPGS and Soluplus® for co-delivery of paclitaxel and fenretinide
Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects as a single agent and chemotherapy synergist in vitro. When a human ovarian cancer cells line (A2780s) was treated with both PTX and 4-HPR, there was a…
Nanoemulgel for Improved Topical Delivery of Retinyl Palmitate
Retinyl palmitate is a vitamin A ester belonging to the family of endogenous natural retinoid and used to treat various skin disorders like acne, skin aging, wrinkles, and dark spots, as well as to protect against psoriasis. Despite the…
Therapeutic effects of celecoxib polymeric systems in rat models of inflammation and…
The incidence of rheumatoid arthritis (RA), an autoimmune inflammatory disease, is rapidly increasing in aging societies. In the current study, celecoxib (CXB) micelles were developed to improve the oral absorption and anti-inflammatory…
Microwave-assisted β-cyclodextrin/chrysin inclusion complexation: An economical and green strategy…
Highlights
• 1:1 solid inclusion complex (IC) of chrysin with β-cyclodextrin prepared.
• Microwave irradiation method is time-saving and environmentally benign.
• Microwaved IC has highest drug content, solubility and…
Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for…
This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When fabricating the PC-based solid dispersion, we employed…
Top 200 Drugs 2019 – The Poster
Top 200 Pharmaceuticals by Retail Sales in 2019
Jon Njardarson from the University of Arizona has just published the poster with the Top 200 Brand Name Drugs by Retail Sales in 2019. It starts with Humira (Immunology) - USD 19.723…
Is cannabidiol a scheduled controlled substance? Origin makes the difference
Cannabidiol (CBD) is the main cannabinoid naturally occurring in hemp. It has recently attracted the attention of the scientific community because of its numerous pharmacological activities. However, its legal status changes depending on…
Feeding of particle-based materials in continuous solid dosage manufacturing: a material science…
The pharmaceutical industry today is experiencing a paradigm shift from batch to continuous manufacturing, which promises greater flexibility to target diverse populations, as well as more-consistent product quality to ensure best efficacy.…
The Evolution of Cellulose in Tableting Technology
How the evolution from traditional powdered cellulose to microcrystalline cellulose to a new generation of co processed high functionality excipients can benefit tableting processes including continuous manufacturing applications. This…
Enhancing in vivo oral bioavailability of cajaninstilbene acid using UDP-glucuronosyl transferase…
Cajaninstilbene acid (CSA) exerts wide pharmacological activities, such as anti-inflammation, hypoglycaemic activity, analgesic effect and cognition improvement. However, it underwent severe phase II metabolism mediated by…
Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient…
Polydopamine (PDA) is a bioinspired fascinating polymer which is considered nowadays as a material of choice for designing drug delivery nanosystems. Indeed, PDA exhibits multiple interesting features including simple preparation protocols,…
Nanostructured lipidic carriers for dual drug delivery in the management of psoriasis: Systematic…
In the present study, we selected two potential herbal drugs (Smilax china and Salix alba) and developed nano lipidic carriers (NLC) gel for safe and effective topical therapy against psoriasis. Optimization of formulation of NLCs was…
Determining Particle Size of Polymeric Micelles in Thermothickening Aqueous Solutions
Many active pharmaceutical ingredients (APIs) are poorly soluble and cause inadequate drug absorption. Soluplus®, a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, is a commercial excipient (BASF Corp) that…
Process analytical technology tools for process control of roller compaction in solid…
Powders are often granulated to improve their flow properties, content uniformity and processability. Dry granulation is increasingly becoming a preferred granulation technique in the pharmaceutical industry because it makes manufacturing…
Preparation of Bilayer ODTs with Superior Interfacial Strength Using GRANFILLER-D
In recent years, multilayer tablets have drawn attention as dosage form that enable the production of combination drugs with API stability and precisely controlled dissolution rates, and many studies on such tablets have been reported.…
A dual pH and microbiota-triggered coating (PhloralTM) for fail-safe colonic drug release
Enteric-coated dosage forms are widely used for targeting the ileo-colonic region of the gastrointestinal (GI) tract. However, accurate targeting is challenging due to intra- and inter-individual variability in intestinal paramaters such as…
What makes a drug discovery consortium successful?
Consortia are enabling drug discovery in areas that individual organizations are unable to support alone because of the high risk or the need to pool information. This article discusses desirable features that can underpin the success of…
Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles:…
Background: Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there’s a need for designing efficient novel drug delivery systems that may enhance of precorneal retention…
Recent Advances of D-α-tocopherol Polyethylene Glycol 1000 Succinate Based Stimuli-responsive…
D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) is a pharmaceutical excipient approved by Chinese NMPA and FDA of USA. It’s widely applied as a multifunctional drug carrier for nanomedicine. The advantages of TPGS include…
The Role of Functional Excipients in Solid Oral Dosage Forms to Overcome Poor Drug Dissolution and…
Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds is usually very…
Enhancement of loading and oral bioavailability of curcumin loaded self-microemulsifying lipid…
The therapeutic applications of curcumin, a phenolic compound extracted from Curcuma species, is limited due to poor bioavailability. To enhance the bioavailability, self-microemulsifying drug delivery systems (SMEDDS) with curcumin were…
Application of star poly(ethylene glycol) derivatives in drug delivery and controlled release
Multi-arm star poly(ethylene glycol) (PEG) polymers have a number of advantages over linear PEG polymers when used as carriers for drug delivery and controlled release. For instance, they have more terminals that can be modified to form…
MEDICINAL CANNABIS AND THE GACP/GMP JUNGLE
Medicinal Cannabis can support various treatments in reducing side effects and symptoms, such as nausea and pain. Medicinal Cannabis, however, has to comply to GMP requirements as any medicinal substance or product has. Navigate the…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 Lactose properties and behavior in 3D powder bed printing
#2 Superior Lubrication Performance of Sodium Stearyl Fumarate in…
OPTICORE™, an innovative and accurate colonic targeting technology
Inflammatory bowel disease (IBD) is a debilitating condition, estimated to affect 7 million people worldwide. Current IBD treatment strategies are substandard, relying on colonic targeting using the pH gradient along the gastrointestinal…
The race for coronavirus vaccines: a graphical guide
More than 90 vaccines are being developed against SARS-CoV-2 by research teams in companies and universities across the world. Researchers are trialling different technologies, some of which haven’t been used in a licensed vaccine before.…
Development and Evaluation of an In-line and On-line Monitoring System for Granule Size…
Roll compaction/dry granulation is established in manufacturing of solid oral dosage forms and, within the context of continuous manufacturing, it has sparked interest as material is fed, processed, and ejected continuously while also…
Calcitriol Tablets with Hybrid Lipid based Solid Dispersions with Enhanced Stability and Content…
Calcitriol, as the biologically active form of vitamin D3, is essential for patients with renal osteopathy. The solubilization, stabilization, and content uniformity are key issues in its formulation development. In our previous study, the…
Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets
Solidification of self-microemulsifying drug delivery systems (SMEDDS) is a rising experimental field with important potential for pharmaceutical industry, however fluid-bed granulation with SMEDDS is yet an unexplored solidification…
Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals— The…
In this paper, the role of mesoporous silica (MS) particle size in the stabilization of amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug, the two MS materials (Syloid® XDP 3050 and Syloid®…
Immediate Hypersensitivity Reactions Caused by Drug Excipients: A Literature Review
The European Medicines Agency defines excipients as the constituents of a pharmaceutical form apart from the active substance. Immediate hypersensitivity reactions (IHRs) caused by excipients contained in the formulation of medications have…