The benefits of lactose as an excipient
Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of using lactose as an excipient.
Medicines are…
Poloxamer modified florfenicol instant microparticles for improved oral bioavailability
Surfactants can improve the hydrophobicity of poorly water-soluble drugs and increase the stability of microparticles by reducing surface tension. This study describes that surfactant-engineered florfenicol instant microparticles (FIMs)…
Enhanced dissolution and oral bioavailability of poorly water-soluble herb (Kaempferia parviflora)…
Kaempferia parviflora (KP) is a Thai traditional herb. The primary pharmacologically active substances are methoxyflavones, namely, 5,7-dimethoxyflavone, 5,7,4′-trimethoxyflavone, and 3,5,7,3′,4′-pentamethoxyflavone. These methoxyflavones…
Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable…
In current study, it was investigated if the moisture-mediated polymorphic transition from δ- to β-mannitol during twin screw granulation (TSG) also took place in high drug loaded formulations and if the specific granule morphology…
A tunable extruded 3D printing platform using thermo-sensitive pastes
Extruded 3D printing is emerging as an attractive fabrication technology in the field of personalized oral medicines. The objective of this study was to develop a tunable extruded 3D printing platform based on thermo-sensitive gelatin…
Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble…
Over the last twenty years, the poor solubility profile of pipeline drugs has limited their development as solid oral dosage forms. Formulating these APIs as amorphous solid dispersions is one strategy to overcome their poor aqueous…
Which Tableting Process is Right for You?
Explore a world of tableting possibilities with 3 different methods: direct compression, wet granulation, and roller compaction. Have a look at this interesting video from 2016 from Merck.
Thermodynamic Aspects of the Preparation of Amorphous Solid Dispersions of Naringenin with Enhanced…
Amorphous ternary solid dispersions of poorly water-soluble Naringenin (NRG) in Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in a Hot- Melt Extruder (HME) using the principle of Low-Temperature Solubilization. Before HME, the…
ZoomLab™, Your Virtual Pharma Assistant
ZoomLab™ is a free online tool that has been developed for formulators, by formulators.
ZoomLab™ removes needless trial and error from the drug formulation process by testing and predicting multiple aspects of an oral solid dosage…
Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt…
Amorphous solid dispersions (ASDs) are commonly used in the pharmaceutical industry to improve the dissolution and bioavailability of poorly water-soluble drugs. Hot melt extrusion (HME) has been employed to prepare ASD based products.…
Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles
Aripiprazole (ARP) is an antipsychotic drug approved for the treatment of schizophrenia. It is poorly water-soluble and undergoes extensive hepatic metabolism and P-gp efflux, which lead to poor bioavailability and increased dose-related…
Superior Lubrication Performance of Sodium Stearyl Fumarate (Alubra®) in Direct Compression and…
Lubricants are agents added in small quantities to tablet and capsule formulations to improve certain processing characteristics such as decreasing friction, preventing adherence and improving flowability. For the last many decades, the…
Lactose properties and behavior in 3D powder bed printing
Working with the Netherlands Organization for Applied Scientific Research (TNO), DFE Pharma tested 20 lactose grades in 3D powder bed printing. The primary objective of this study was to select lactose with sufficient flow, wetting and…
Research and Review of Polymethyl-methacrylate Copolymers in the Development of Enhanced…
The following thesis shall primarily explore the current research regarding the implementation of modifiable microscopic and nanoscopic polymer particles as novel pharmaceutical delivery systems. Polymethacrylate-based copolymers, such as…
Review of Real-Time Release Testing of Pharmaceutical Tablets: State-of-the Art, Challenges and…
In the last decade significant advances have been made in process analytical technologies and digital manufacturing of pharmaceutical oral solid dosage forms leading to enhanced product knowledge and process understanding. These…
Characterization and comparison of deferasirox fast disintegrating tablets prepared by direct…
The aim of this study was to develop direct compressed and lyophilized fast disintegrating/dissolving tablets (FDTs) that enhanced disintegration and dissolution of deferasirox, a drug with poor solubility and bioavailability. Although…
Channelled tablets: An innovative approach to accelerating drug release from 3D printed tablets
Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling…
The influence of polymeric excipients on desupersaturation profiles of active pharmaceutical…
Polymeric excipients have proven to be beneficial in stabilizing supersaturated solutions of poorly soluble active pharmaceutical ingredients (APIs). They are therefore considered an important tool in improving oral bioavailability of such…
A first principle model for simulating the ribbon solid fraction during pharmaceutical roller…
Solid fraction is a key intermediate product attribute which significantly affects the granule characteristics prepared in a roller compaction (RC) process. Implementing the quality by design (QbD) in pharmaceutical manufacturing requires…
Innovative Technologies for amorphous solid dispersions
More and more poorly water-soluble or even water-insoluble drug candidates show up in pharmaceutical development. Achieving a good bioavailability and efficacy requires technical platforms and processes. Solid dispersions and amorphous…
Electrospun Nimodipine-loaded fibers for nerve regeneration
Nimodipine is a 1,4-Dihydropyridine type calcium antagonist routinely used to control blood pressure and reduce the risk of secondary ischemia after aneurismal subarachnoid hemorrhage. Additionally, Nimodipine has unique neuroprotective…
Characterization of a novel hydroxypropyl methylcellulose (HPMC) direct compression grade excipient…
Controlled release tablets are important dosage forms enabling a slower release of the drug and better pharmacokinetics for some drugs and hydrophilic matrix tablets utilizing hydroxypropyl methylcellulose (HPMC) are one of the most common…
Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for…
The purpose of this study was to develop Pickering water-in-oil nano-emulsions only stabilized by Eudragit RL100 nanoparticles (NPs), in order to increase the nano-emulsion stability and create a barrier to improve the drug encapsulation…
Development of alginate esters as novel multifunctional excipients for direct compression
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain…
European Paediatric Formulation Initiative workshop report: Improving the administration of oral…
Accurate dosing of the right medicine to the right patient is a key element of safe and efficacious pharmacotherapy, yet prone to technical challenges and human error when dosing involves the administration of small volumes of liquid…
Multi-Methodological Quantitative Taste Assessment of Anti-Tuberculosis Drugs to Support the…
The unpalatability of antituberculosis drugs is often cited as a major cause of non-adherence in children, yet limited quantitative taste assessment data are available. The aim of this research was to quantify the bitterness of isoniazid,…
A semi-theoretical model for simulating the temporal evolution of moisture-temperature during…
Moisture plays a major role in determining the attributes of granules prepared by fluidized bed granulation (FBG). Here, a semi-theoretical droplet-based evaporation rate model was developed and incorporated into moisture mass-enthalpy…
Static and dynamic structural features of single pellets determine the release behaviors of…
The multiple-unit sustained-release (MUSR) dosage forms containing numerous sustained-release subunits present a reliable choice for oral formulation of controlled release systems. As a typical MUSR, the metoprolol succinate…
Estimation of Water Content in Cellulose Materials
Many technical issues, such as those involved in developing wastewater remediation methods, concern the interaction between cellulose and water. That is why, it is important to understand how water interacts with cellulose materials. It is…
Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules…
The particle size reduction of active pharmaceutical ingredients is an efficient method to overcome challenges associated with a poor aqueous solubility. With respect to stability and patient’s convenience, the corresponding nanosuspensions…
Engineering oral delivery of hydrophobic bioactives in real-world scenarios
Bioactive compounds, often hydrophobic in nature, tend to degrade during processing outside or inside the body with rapid clearance rates, resulting in poor bioavailability. In this review, we survey recent scientific advances in…
Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl…
Excessive exposure to solar radiation induces injurious effects on human skin. Our previous study evidenced that protocatechuic acid (P0) and ethyl protocatechuate (P2) act against photodamage and photoaging. The present study aimed to…
Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol® Enabled Amorphous Solid…
Abiraterone is a poorly water-soluble drug. It has a high melting point and limited solubility in organic solvents, making it difficult to formulate as an amorphous solid dispersion (ASD) with conventional technologies. KinetiSol® is a…
The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the…
Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin
The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination…