The benefits of lactose as an excipient
Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of using lactose as an excipient.
Medicines are…
Multicomponent solid dispersion: A new generation of solid dispersion produced by spray-drying
The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In…
Mechanistic understanding of granule growth behavior in bi-component wet granulation processes with…
Two case studies were studied in a high shear wet granulator using a hydrophobic API and a hydrophilic excipient An increase in granule growth was observed with an increase in percentage composition of the hydrophobic API Regime map…
Webcast – Market Trends & Clean Label Solutions for Solid Oral Dosage Forms – with…
Webcast - Wednesday, 6th May 2020 - 3:00 PM CET
Want to discover what drives the dietary supplement consumer today and in future? What does the industry has to do to satisfy the consumer needs? What does Clean Label mean for manufacturers…
A study on the impact of HPMC viscosity grade and proportion on the functional properties of…
The co-processing of multiple excipients is driven by the potential of diversifying the properties and functionality of excipients when they are combined. Bulk freeze-drying-milling is a novel secondary processing approach to develop…
Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges
Additive manufacturing (AM) is considered the latest technology that creates breakthrough innovations and addresses complex medical problems. This is clearly demonstrated by the promising results obtained in regenerative medicine,…
Personalised 3D Printed Medicines:Optimising Material Properties for Successful Passive Diffusion…
Although not readily accessible yet to many community and hospital pharmacists, fuse deposition modelling (FDM) is a 3D printing technique that can be used to create a 3D pharmaceutical dosage form by employing drug loaded filaments…
Preclinical evaluation of new formulation concepts for abiraterone acetate bioavailability…
Abiraterone acetate is a potent drug used for the treatment of metastatic castration resistant prostate cancer. However, currently marketed product containing crystalline abiraterone acetate exhibits strong positive food effect which…
Oral tablet formulations containing cyclodextrin complexes of poorly water soluble cefdinir to…
Cefdinir (CFD) is an oral cephalosporin antibiotic commonly used in the treatment of community-acquired infections. The oral bioavailability of CFD is limited due to its poor aqueous solubility. Cyclodextrins (CyDs) and their chemically…
Personalised 3D Printed Medicines: Optimising Material Properties for Successful Passive Diffusion…
Although not readily accessible yet to many community and hospital pharmacists, fuse deposition modelling (FDM) is a 3D printing technique that can be used to create a 3D pharmaceutical dosage form by employing drug loaded filaments…
Webcast – Qualit-e: Securely upload and share quality documents – with Nadine Blaettler…
Webcast - Thursday, 30th April 2020 - 4 PM CET
Do you get more inquiries about quality documents than you sell raw materials? Is the rule 1 kg raw material = 1 kg documents true to you?
Then let us show you how you can easily reduce this…
Kolliphor® P 188 Bio – High purity poloxamer in biologics manufacturing
Manufacture of biologics in suspension cell culture causes damage to the cell membranes (shear stress). The majority of the damage occurs due to agitation from the impellor, and during gas sparging at the bubble layer, regardless of the…
Friday’s Top 5 by pharmaexcipients
Find a summary of the most popular posts on excipients and formulation of the last week:
Top posts of the week
#1 New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
#2 European CMOs capability mapping
#3…
Multiple-component dual-phase solid lipid nanoparticles with conjugated transferrin for formulating…
Internal aqueous phase was incorporated in solid lipid nanoparticles (SLNs) containing 5 lipid components to form dual-phase SLNs (DPSLNs), which were then conjugated with transferrin (Tf) to transport nerve growth factor (NGF), rosmarinic…
Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the…
This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and…
Experimental design approach for development of novel microemulsion system and immediate release…
The objective of this study was to determine specific combination of pharmaceutical excipients that lead to formulation of efficient nebivolol hydrochloride SMEDDS and its subsequent formulation into IR-SET (Immediate release- Self…
European Pharma Companies Mapping
Fuliginous Management Ltd is a service providing company to the Contract Manufacturing Market, supporting both CMOs and Pharma Companies cooperating with CMOs.
The main services provided to CMOs include support in business development in…
Non-intrusive high resolution in-vitro measurement of regional drug powder deposition
Optical Coherence Tomography (OCT) is a high-resolution and non-invasive cross-sectional imaging technique mainly used for medical imaging and industrial non-destructive testing. However, its feasibility in the quantification of pulmonary…
Mixed micelles of TPGS and Soluplus® for co-delivery of paclitaxel and fenretinide: in vitro and in…
Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects as a single agent and chemotherapy synergist in vitro. When a human ovarian cancer cells line (A2780s) was treated with both PTX and 4-HPR, there was a…
Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of…
Abstract
Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients.
Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin…
Bioavailability enhancement of repaglinide from transdermally applied nanostructured lipid carrier…
Repaglinide (RG) is an effective anti-diabetic drug (BCS class II) with limited oral bioavailability < 55% due to poor solubility and high first-pass hepatic metabolism. The aim of the paper was to formulate repaglinide loaded…
Oral Delivery of Teriparatide Using a Nanoemulsion System: Design, in Vitro and in Vivo Evaluation
PURPOSE:
Investigate the possibility of delivering teriparatide orally using nanoemulsion.
METHOD:
Teriparatide was allowed to interact with chitosan in the presence of HPβCD.The formed polyelectrolyte complex (PEC) was characterized by…
The Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks
In light of the current novel coronavirus (COVID-19) pandemic as well as other viral outbreaks in the 21st century, there is a dire need for new diagnostic and therapeutic strategies to combat infectious diseases worldwide. As a convergence…
European CDMOs capability mapping – Small Molecules and Biologics
Fuliginous Management Ltd is a service providing company to the Contract Manufacturing Market, supporting both CMOs and Pharma Companies cooperating with CMOs. Get prepared for 2021 and acquire the updated CDMOs capibility mapping.…
Overcoming the yuk factor: effective taste-masking approaches for bad tasting drugs
Learn about two relatively straight forward approaches for taste-masking bitter API with a lipid excipient. A short case study on formulation and characterization will be presented to illustrate proof of concept.
Thursday 23rd April: Two…
A Microfluidic Platform to design Multimodal PEG – crosslinked Hyaluronic Acid Nanoparticles…
The combination of different imaging modalities can allow obtaining simultaneously morphological and functional information providing a more accurate diagnosis. This advancement can be reached through the use of multimodal tracers, and…
Triamcinolone Acetonide-Loaded PEGylated Microemulsion for the Posterior Segment of Eye
Present work investigates the possibility of a polyethyleneglycolylated (PEGylated) microemulsion (ME) to deliver drug to the posterior segment of eye. Triamcinolone acetonide (TA), a widely used drug in intraocular diseases, was selected…
Solubility Improvement of Progesterone from Solid Dispersions Prepared by Solvent Evaporation and…
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl…
Maximizing the bioavailability of carbamazepine with cosolvent-based formulation
The purpose of this research was to investigate drug dose, solubility, permeability, and their interplay, as key factors in oral formulation development for lipophilic drugs. A PEG400-based formulation was studied for five doses of the…
Evaluating two nanocarrier systems for the transdermal delivery of sodium alendronate
Sodium alendronate is a nitrogen-containing bisphosphonate, widely used for osteoporosis treatment. However, due to its several oral administration drawbacks, the transdermal route represents an interesting option. The aim of this study was…
Enhancement of abiraterone acetate oral bioavailability by supersaturated-silica lipid hybrids
Abiraterone acetate (AbA) has an oral bioavailability of <10% due to its poor water solubility. Here we investigate the performance of silica-lipid hybrids (SLH) and supersaturated SLH (super-SLH) in improving oral bioavailability of…
Development and evaluation of zopiclone compression coated tablet for time-controlled pulse release
Early-morning awakening is a special insomnia characterized with circadian rhythm. In this study, zopiclone (ZOP), one of the common hypnotics, was selected to prepare zopiclone pulse release tablet via compression coating. Single-factor…
Hopper Design & Powder Flow – Hopper Design Cliff Notes
There are two general flow patterns that can occur when a bulk solid is discharged from a hopper: funnel flow and mass flow. In funnel flow, an active flow channel forms above the outlet, with stagnant material remaining at the periphery.…
Strawberry-Enabled Oral Delivery of Protein Drugs
Although oral drug delivery is preferred by patients, it is not possible for proteins because the gastrointestinal tract is not sufficiently permeable. To enable the non-toxic oral uptake of protein drugs, we investigated plant-based foods…
New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now…