The benefits of lactose as an excipient
Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of using lactose as an excipient.
Medicines are…
Carvacrol loaded nanostructured lipid carriers as a promising parenteral formulation for…
Leishmaniasis are a group of neglected infectious diseases caused by protozoa of the genus Leishmania with distinct presentations. The available leishmaniasis treatment options are either expensive and/or; cause adverse effects and some are…
Novel interpenetrating polymeric network based microbeads for delivery of poorly water soluble drug
A well-designed drug delivery platform improves the pharmacological properties of therapeutics. Here, we report a biodegradable interpenetrating polymer network (IPN) microbeads delivery technology developed by crosslinking a polymer blend…
Oral delivery of non-viral nucleic acid-based therapeutics – do we have the guts for this?
Gene therapy with RNA and pDNA-based drugs is limited by poor enzymatic stability and poor cellular permeation. The delivery of nucleic acids, in particular by the oral route, remains a major hurdle. This review will focus on the barriers…
Antifungal and Antiparasitic Drug Delivery
Fungal and parasitic diseases affect more than a billion people across the globe, one-sixth of the world’s population, mostly located in developing countries. The lack of effective and safer treatments combined with a deficient diagnosis…
Excipients Week
Highlight Article
Learn more about "Phospholipid-Based Delivery Systems – Advanced Vaccines in Modern Medicine" - The routine use of vaccines is one of the most outstanding accomplishments of modern medicine. The first major milestone was…
Partial Tablet Coating by 3D Printing
In the last decade 3D printing (3DP) technology has gained increasing interest in the pharmaceutical field addressing several novel challenges such as on-demand manufacturing at the point of need, customization of drug release profiles and…
Inhalable Nano into Micro Dry Powders for Ivacaftor Delivery: The Role of Mannitol and Cysteamine as…
In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles…
Contribution to the Improvement of an Oral Formulation of Niclosamide, an Antihelmintic Drug…
Niclosamide (NCL) is an effective anthelmintic agent that has been shown to possess broad-spectrum antiviral activity, including against SARS-CoV-2. Due to its poor solubility in aqueous medium, however, the commercially available NCL…
Oral administration of protein nanoparticles: An emerging route to disease treatment
Over the last two decades, developments in nanomedicine have resulted in technical advances with application to clinical science. Both organic and inorganic nanoparticles (NPs) have shown tolerability, pharmacologic specificity and…
Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid…
Andrographolide (AG), a major diterpene lactone isolated from Andrographis paniculata (Burm. f.) Nees (Acanthaceae), possesses a wide spectrum of biological activities. However, its poor water solubility and low bioavailability limit its…
Lipid nanocapsules to enhance drug bioavailability to the central nervous system
The central nervous system (CNS), namely the brain, still remains as the hardest area of the human body to achieve adequate concentration levels of most drugs, mainly due to the limiting behavior of its physical and biological defenses.…
Dual drug-loaded coaxial nanofibers for the treatment of corneal abrasion
Corneal abrasion is a scratch wound on the surface of the anterior segment of the eye, which can predispose a patient to corneal infection and scarring, particularly if the cut penetrates to the deep corneal layers. Here we investigate a…
How to clean enteric polymers
Why Common Approaches Are Not Effective
The mechanism of action for cleaning enteric polymers is straightforward. Because enteric polymers are chemically acidic, their solubility and therefore their release is pH dependent. As a result,…
Ebselen nanoemulgel for the treatment of topical fungal infection
Superficial mycoses are the fungal infections of skin, hair and nail which affect thousands of people worldwide. Emerging resistance to azole antifungals is a common problem in the treatment of superficial or systemic fungal infection.…
Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to…
Rutin is one of the most important flavonoids with poor bioavailability. This work aimed at addressing the issue of poor biopharmaceutical performance of rutin by applying a combination of complexation with secondary processing into…
Development and Evaluation of Mucoadhesive Buccal Dosage Forms of Lidocaine Hydrochloride
Intraoral lidocaine formulations are applied in children and adults for pain relief. The potential risks associated with orally administered lidocaine due to accidental ingestions were highlighted in a warning letter by the US Food and Drug…
Physical modification of Thai rice starch and its application as orodispersible film former
The objective of this study was to investigate the application of the physically modified rice starch (MRS) produced by alcoholic-alkaline (MRS-AA) and planetary ball-milling (MRS-BM) methods as an ODF film former. Rice starch was isolated…
How Pharmaceutical Companies Can Increase Production to Help Fight Covid-19
Since the Corona cases soared in February 2020, the world has come to a halt, except for the Healthcare sector, where, people are doing whatever it takes to stop the spread of this infection and cure the thousands that are infected.…
Excipact Procedure For Audit Postponement And Remote Audits
6th April 2020
In response to the COVID-19 pandemic and following the EXCIPACT position paper of 24 March 2020, this document sets out a new procedure for audit postponement and the use of remote audits for those pharmaceutical…
Oral Drug Delivery: Oral Delivery of Biologics for Precision Medicine
The emerging field of precision medicine is rapidly growing, fostered by the advances in genome mapping and molecular diagnosis. In general, the translation of these advances into precision treatments relies on the use of biological…
Engineering approaches for drug delivery systems production and characterization
To find and to test the therapeutic effectiveness (and the limited adverse effects) of a new drug is a long and expensive process. It has been estimated a period of ten years and an expense of the order of one billion USD are required.…
New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19
Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to fight the coronavirus outbreak. College of Pharmacy researchers at The University of Texas at Austin are now…
Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral…
In this study, we developed ticagrelor-dispersed nanosuspension (TCG-NSP) to enhance the dissolution and oral bioavailability of ticagrelor (TCG) through a statistical design approach. TCG, a reversible P2Y12 receptor antagonist, is…
Pharma Excipients – A platform for academia and pharmaceutical students
It is estimated that more than 90% of drugs need a pharmaceutical excipient to be formulated in an administrable form. Not all drugs are created equal. Each requires its own manufacture and excipients to be formulated in a drug product.…
Roquette launches an online technical platform for researchers and drug developers
The new platform – “Innovation Hub” – and its virtual assistant – “Rosa”- offer pharmaceutical scientific community new opportunities for formulation ideas and information exchange
Geneva, IL (USA), March 31, 2020 – As virtual…
End-to-End Continuous Manufacturing of Conventional Compressed Tablets: From Flow Synthesis to…
An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time. The output reaction mixture of the flow synthesis of…
Dosage form designs for the controlled drug release of solid dispersions
Although solid dispersions have been reported as an efficient drug delivery system, the design of specific dosage forms for pharmaceutical therapy is necessary to improve the solubility and bioavailability of poorly water-soluble drugs.…
Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons
Drug-coated balloons (DCBs), which deliver anti-proliferative drugs with the aid of excipients, have emerged as a new endovascular therapy for the treatment of peripheral arterial disease. In this study, we evaluated the use of keratose…
Solving a sticking related tablet problem by multivariate statistics and computational tomographic…
This work identifies the cause of sticking of granules in an industrial process of tableting. Retrospective multivariate statistical analysis of industrial scale batches' records (PLS, properties and manufacturing conditions of granules and…
Lyophilisation Improves Bioactivity and Stability of Insulin-Loaded Polymeric-Oligonucleotide…
The oral bioavailability of therapeutic proteins is limited by the gastrointestinal barriers. Encapsulation of labile proteins into nanoparticles is a promising strategy. In order to improve the stability of nanoparticles, lyophilisation…
Zein as a water insoluble excipient for spray dry encapsulation of hydrophilic bioactives
Anti-solvent precipitation of zein was employed in conjunction with spray drying to reduce the usage of ethanol and to encapsulate the aqueous extract of green jelly leaf (Cyclea barbata Miers) antioxidants. Different concentrations of zein…
Localized Delivery of Ibuprofen via a Bilayer Delivery System (BiLDS) for Supraspinatus Tendon…
The high prevalence of tendon re‐tear following rotator cuff repair motivates the development of new therapeutics to promote improved tendon healing. Controlled delivery of non‐steroidal anti‐inflammatory drugs (NSAIDs) to the repair site…
Rational design to biologics development: the polysorbates point of view
Formulation development is an essential part of any biopharmaceuticals development programme, and this will affect quality, safety and efficacy of the final drug product. The vast majority of biopharmaceuticals on the market are therapeutic…
Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate
Purpose
Abiraterone acetate (AbA) is a poorly water-soluble drug with an oral bioavailability of <10% and a significant pharmaceutical food effect. We aimed to develop a more efficient oral solid-state lipid-based formulation for AbA…