Formulation of semi-solid dosage forms indented for transdermal delivery of ivermectin
The story of ivermectin originated in 1974, when scientist Satoshi Omura discovered Streptomyces avermitilis, which later led to the isolation of an active compound, avermectin and finally, ivermectin . Ivermectin, which consists of two homologs (namely dihydro-avermectin B1b and dihydro-avermectin B1a) , is a broad-spectrum anti-parasitic drug. It…
Development and Optimization of Self-nanoemulsifying Drug Delivery System of Ibrutinib
Objective: The present research demonstrates the formulation of novel self-nanoemulsifying drug delivery system (SNEDDS) for potential delivery of ibrutinib by oral route.
Materials and Methods: Ibrutinib SNEDDS formulation optimized…
Screening of stabilizing agents to optimize flurbiprofen nanosuspensions using experimental design
Although flurbiprofen (FB), as one of non-steroidal anti-inflammatory drugs, has various pharmacological applications, it shows low dermal bioavailability due to its low water solubility. To overcome this solubility problem, FB…
Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected
Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented…
Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical…
Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its…
PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of…
As the main symptom of Alzheimer’s disease-related dementia is memory loss, patient compliance for donepezil hydrochloride (donepezil), administered as once-daily oral formulations, is poor. Thus, we aimed to design poly(lactic-co-glycolic…
Influence of the Punch Speed on the Die Wall/Powder Kinematic Friction During Tableting
Influence of the compaction speed on the final tablet properties is an important challenge during the scale-up of a solid dosage form. This strain rate sensitivity is generally attributed to the time dependent deformation behavior of the…
USP: Pandemic Preparedness for Regulators in Low- and Middle-Income Countries
The COVID19 pandemic is testing global medical supply chains. Read the new US Pharmacopeia paper on Pandemic Preparedness for Regulators in Low- and Middle-Income Countries. This is the first one in the new series on pandemic preparedness…
Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes
Compaction simulators are frequently used in the formulation and process development of tablets, bringing about the advantages of flexibility, low material consumption, and high instrumentation to generate the most possible process…
Does the Formulation of Oral Solid Dosage Forms Affect Acceptance and Adherence in Older Patients? A…
Age-related changes mean that the older population can encounter barriers toward taking medication orally. Further work is needed to identify the characteristics of oral solid dosage forms that will improve patient acceptance and adherence.…
Image-based Characterization of Powder Flow to Predict the Success of Pharmaceutical Minitablet…
Powder flowability plays an important role in die filling during tablet manufacturing. The present study introduces a novel small-scale measuring technique for powder flow. Based on image analysis, the flow was defined depending on the…
Pfanstiehl Inc, USA- Helping accelerate COVID19 research to develop Vaccine, Diagnosis and Cure
Pfanstiehl (IL, USA) is a global leader in developing High Pure/Low Endotoxin Viral Vector, Protein and Vaccine stabilizers ( eg. HPLE-Trehalose, Sucrose, Histidine, Arginine ,Mannitol, Sodium Succinate etc.) that are used in producing many…
SPI Pharma expands line of mannitol products
Announced by SPI Pharma - The Company has added four mannitols to its Mannogem line, designed for optimala compressibility, binding, disintegration and particle size ranges. Read the full artile here:…
A Theoretical Study on Trehalose + Water Mixtures for Dry Preservation Purposes
The properties of trehalose + water mixtures are studied as a function of mixture composition and temperature using molecular dynamics simulations. As trehalose disaccharide has been proposed for dry preservation purposes, the objective of…
Ellagic Acid Containing Nanostructured Lipid Carriers for Topical Application: A Preliminary Study
Ellagic acid (EA) is a potent antioxidant substance of natural origin characterized by poor biopharmaceutical properties and low solubility in water that limit its use. The aim of the present study was to develop lipid-based nanoparticle…
Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side effects,…
Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of…
The clinical translation of the multiple pharmacological effects of resveratrol (RSV) found in preclinical studies has been impaired by its poor bioavailability, due to poor solubility and rapid metabolism and elimination. The inclusion of…
Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nanoemulsion using Liquisolid…
Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced approach that can address low oral bioavailability issues. The antihypertensive drug, nebivolol (NBH), has low bioavailability, about 12%, due to its poor solubility and…
Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral…
Pioglitazone (PGL) is a hypoglycemic therapeutic agent used in the treatment of diabetes (type 2). The present research work was designed to prepare and optimize PGL loaded solid lipid nanoparticles (SLNs). The formulation was optimized…
Investigation of water vapour sorption mechanism of starch-based pharmaceutical excipients
Starch-based excipients are commonly used in oral solid dosage forms. The effect of particle size and pregelatinisation level of starch-based excipients on their water absorption behaviour have been evaluated. The results showed that…
Novel approach to evaluating granulation and segregation level considering the contribution of…
The granulation process is critical to the uniformity of not only the active ingredient (API) but also other excipients in granules. Insufficient granulation results in unexpected product quality, e.g. delayed dissolution and lack of…
Rifampicin nanocrystals: Towards an innovative approach to treat tuberculosis
Tuberculosis (TB) is one of the top ten causes of death worldwide and a leading cause of death in HIV patients. Rifampicin (Rif), a low water-soluble drug, is a critical first-line treatment and the most effective drug substance for therapy…
Formation of protein sub-visible particles during powder grinding of a monoclonal antibody
We have observed an interesting phenomenon in which grinding of freeze-dried monoclonal antibody X (mAb-X) formulation powder resulted to significant protein sub-visible particles (SbVPs) in the reconstituted liquid, which could only be…
Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for…
Freeze-drying, until now, has been a process that was designed using a trial and error experimental approach. This approach is often material and time consuming, and the resulting freeze-drying processes are neither optimum nor robust.…
Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus…
Currently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, formerly known as 2019-nCoV, the causative pathogen of Coronavirus Disease 2019 (COVID-19)) has rapidly spread across China and around the world, causing an outbreak of…
Overview of the Advantages and Disadvantages of Different Mucosal Sites for the Delivery of…
Nanoparticles (NPs) often improve the efficacy of therapeutic actives, and their delivery to mucosal sites allows for unique and localized effects compared to parenteral delivery. Sites of mucosal surfaces includes the eyes, nasal cavity,…
Approaches to improve intestinal and transmucosal absorption of peptide and protein drugs
The oral bioavailability of hydrophilic and macromolecular drugs is generally poor owing to their poor membrane permeability. For example, peptide and protein drugs are poorly absorbed because of their low stability and poor membrane…
Introduction to Nanomedicine in Drug Delivery
Recent advances in the field of nanotechnology have given a boost to the academic researchers, the pharmaceutical and biomedical industry, allowing its use in drug delivery and medical diagnosis. Nanotechnology allows the formulation of…
Impact of Particle and Equipment Properties on Residence Time Distribution of Pharmaceutical…
Paddle feeders are devices commonly used in rotary tablet presses to facilitate constant and ecient die filling. Adversely, the shear stress applied by the rotating paddles is known to affect the bulk properties of the processed powder…
A Mathematical Approach to Consider Solid Compressibility in the Compression of Pharmaceutical…
In-die compression analysis is an effective method for the characterization of powder compressibility. However, physically unreasonable apparent solid fractions above one or apparent in-die porosities below zero are often calculated for…
COVID-19: Beware of falsified medicines from unregistered websites
EMA is urging the general public not to buy medicines from unauthorised websites and other vendors aiming to exploit fears and concerns during the ongoing pandemic of coronavirus disease (COVID-19).
Vendors may claim that their products…
Elastic recovery in roll compaction simulation
Roll compaction/dry granulation is a widely used granulation method in the pharmaceutical industry. The simulation of the process is of great interest, especially in the early phase of formulation development of solid dosage forms. The…
Additive Manufacturing Technologies for Drug Delivery Applications
Patient to patient variability is one of the issues when administering medications to individuals with different health conditions, pharmacokinetic, age, fitness, gender, and race. This requires introducing smart and personalised drug…
Cost-Benefit of Stockpiling Drugs for Influenza Pandemic
Huerta M, Davidovitch N, Grotto I. Cost-benefit of stockpiling drugs for influenza pandemic. Emerg Infect Dis 2005 Aug http://dx.doi.org/10.3201/eid1108.041156
Abstract
We analyzed strategies for the use of stockpiled antiviral drugs in…
Current formulation approaches in design and development of solid oral dosage forms through…
Three-dimensional (3D) printing technologies are continuously applied to novel fields, laying the foundations for a new industrial revolution. With regard to pharmaceutical sciences, 3D printed drug products are emerging as attractive and…