The benefits of lactose as an excipient
Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of using lactose as an excipient.
Medicines are…
Cost-Benefit of Stockpiling Drugs for Influenza Pandemic
Huerta M, Davidovitch N, Grotto I. Cost-benefit of stockpiling drugs for influenza pandemic. Emerg Infect Dis 2005 Aug http://dx.doi.org/10.3201/eid1108.041156
Abstract
We analyzed strategies for the use of stockpiled antiviral drugs in…
Current formulation approaches in design and development of solid oral dosage forms through…
Three-dimensional (3D) printing technologies are continuously applied to novel fields, laying the foundations for a new industrial revolution. With regard to pharmaceutical sciences, 3D printed drug products are emerging as attractive and…
Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer’s disease
Quercetin was encapsulated in lipid nanoparticles (SLN and NLC) to take advantage of its neuroprotective properties in Alzheimer's disease. The nanoparticles were functionalized with transferrin to facilitate the passage across the…
EXCiPACT Press Release – Wacker Chemical Corporation Site
Wacker Chemical Corporation Site in Eddyville, Iowa, Usa receives EXCiPACT GMP Certification as pharmaceutical excipient supplier
EXCiPACT asbl is pleased to announce that the Wacker Chemical Corporation site in Eddyville, IOWA,…
Controlled and Manageable Release of Antimalarial Artemisone by Encapsulation in Biodegradable…
Nanofiber mats and films are advantageous platforms that can offer unique opportunities as drug carriers in drug delivery technologies. In this research, Artemisone (ART)-loaded polycaprolactone16500-b-α-hydroxy-ω-methoxy poly(ethylene…
Improving the cancer prevention/treatment role of carotenoids through various nano-delivery systems
One of the emerging and recent strategies to combat cancer is application of natural bioactive compounds and phytochemicals. Carotenoids including lycopene, β-carotene, astaxanthin, crocin, β-cryptoxanthin, and lutein, are the main group of…
The Effect of Inorganic Salt on Disintegration of Tablets with High Loading of Amorphous Solid…
Purpose
While including amorphous solid dispersion (ASD) in tablet formulations is increasingly common, tablets containing high ASD loading are associated with slow disintegration, which presents a challenge to control pill burden for less…
Respiratory Drug or Vaccine Delivery Using Nanoparticles
Respiratory diseases account for a very significant portion of worldwide morbidity and mortality but to-date only a limited number of therapeutics are available for direct delivery via inhalation. Nanotechnology offers a range of potential…
EXCiPACT Position Paper: Excipient manufacturer and distributor certification with regards to the…
This position paper indicates how EXCiPACT-Registered Certification Bodies can address some of the impacts arising from the current coronavirus crisis.
Update on March 24th, 2020:
EXCiPACT issued an updated position paper on the Covid19…
Fast dissolving nanofibrous matrices prepared by electrospinning of polyaspartamides
Owing to their versatile chemistry, polyaspartamides have recently attracted increased interest in various biomedical uses such as drug delivery systems and scaffolding materials. Their solubility in organic solvents and in water at…
Control of oral absorption of nutritional supplement using lipid-based formulations (LBFs):…
Among various formulations for oral use, lipid-based formulation (LBF) has been expected as a promising technology to improve the absorption of poorly water-soluble compounds. In the current study, three types of LBFs were tested for their…
Effect of the third component on the aging and crystallization of cinnarizine-soluplus® binary solid…
Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to investigate the effect of the third component on the physical stability and physical aging behavior of cinnarizine-soluplus…
Ginkgo terpenoid against COVID-19
Due to the reported high ability of virulence of COVID_19 in recent months, several studies have been conducted to discover and introduce COVID_19 antiviral drugs. The results of numerous studies have shown that protease inhibitors and…
Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics
Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the…
Liposomes for Enhanced Bioavailability of Water-Insoluble Drugs: In Vivo Evidence and Recent…
It has been known that a considerable number of drugs in clinical use or under development are water-insoluble drugs with poor bioavailability (BA). The liposomal delivery system has drawn attention as one of the noteworthy approaches to…
Continuous twin screw granulation – An advanced alternative granulation technology for use in the…
Hot melt extrusion has been an exciting technology in the pharmaceutical field owing to its novel applicability. Twin-screw granulation presents a great potential and offers many advantages relative to conventional granulation processes.…
Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery
Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as…
Docetaxel-loaded solid lipid nanoparticles prevent tumor growth and lung metastasis of 4T1 murine…
Background
Metastasis causes the most breast cancer-related deaths in women. Here, we investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the treatment of metastatic breast tumors using 4T1-bearing BALB/c…
Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of…
The physiological protective mechanisms of the eye reduce the bioavailability of topically administered drugs above all for those with high molecular weight and /or lipophilic characteristics, such as Cyclosporine A (CyA). The combined…
Design and Synthesis of Polymer Prodrugs for Improving Water-Solubility, Pharmacokinetic Behavior…
Purpose
TXA9, a novel cardiac glycoside, has a potent anti-proliferative effect against A549 human lung cancer cells, however, possesses a poor water-solubility and a rapid metabolic rate in vivo which limited the further development of…
Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s…
Direct nose-to-brain delivery has been raised as a non-invasive powerful strategy to deliver drugs to the brain bypassing the blood-brain barrier (BBB). This study aimed at preparing and characterizing an innovative composite formulation,…
Hydroalcoholic Gel – improvement opportunities to increase daily hygiene
Hydroalcoholic Gel: A range of polymers to formulate with high level of ethanol
Daily hygiene helps to limit illness. Hydroalcoholic gels are mainly composed of high level of alcohol for its disinfecting properties. This high amount of…
Machine Learning Uncovers Excipient-Drug Interactions
Summary:
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed…
What Defines an Ideal Film Coating Process?
Film coating is often considered to be a challenging step in tablet manufacturing. While the choice of film coating depends on factors like API’s characteristics, protective function, release profile of a drug and aesthetics of a tablet,…
Innovation in Laboratory Equipment for solid dosage forms
Glatt MultiLab. The first all in one solution for your lab scale OSD process. Maximum flexibility: All OSD processes are possible, future processes are easy to integrate, perfect space saving foot print for laboratories - fits through any…
Gastroretentive Microballons: A Novel Approach for Drug Delivery
Hollow microballoons (microspheres) are spherical empty particles without core. Microballoons (Hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug-delivery…
Lipid-Based Excipients with Advanced Functionality – Presentation from Drug Delivery &…
At this years Drug Delivery & Formulation Summit in Berlin, Sharareh Salar-Behzadi hold a presentation and showed this interesting research about Lipid-Based Excipients with Advanced Functionality.
Main Topics of the Presentation:…
Implications of superporous hydrogel composites-based gastroretentive drug delivery systems with…
The present research work describes the systematic development and characterization of novel gastroretentive drug delivery system containing superporous hydrogel composites for improving the bioavailability and antihyperlipidemic activity.…
Low temperature, easy scaling up method for development of smart nanostructure hybrid lipid capsules…
Lipid Nanocapsules (LNCs) have been used for drug delivery in cells and animal models for several years. LNCs with unique physicochemical properties for favorable biorecognition, biocompatibility and stimuli responsive (pH/temperature etc.)…
New universal carrier ink for 3D printing
Researchers at ETH have produced a gel from cellulose fibres and biodegradable nanoparticles that liquifies when pressed through the nozzle of a 3D printer, but then quickly returns to its original shape. Their invention paves the way for…
Effect of Solublising Aids on the Entrapment of Loratidine in Pre-Fabricated PVA Filaments used for…
Low drug loading efficiency is the limiting factor in the use of pre-fabricated filaments for 3D printing of pharmaceuticals. The aim of the present study was to modify the material properties of pre-fabricated filament by incorporating…
Design and Development of Darunavir Loaded Self Micro Emulsifying Drug Delivery System using Extreme…
The therapeutic utility of many poorly water-soluble drugs are severely restricted for their bioavailability. The present study was aimed to development of self-micro emulsifying drug delivery (SMEDDS) system for a poorly water soluble…
Review of Terahertz Pulsed Imaging for Pharmaceutical Film Coating Analysis
Terahertz pulsed imaging (TPI) was introduced approximately fifteen years ago and has attracted a lot of interest in the pharmaceutical industry as a fast, non-destructive modality for quantifying film coatings on pharmaceutical dosage…
Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung…
Non-small cell lung cancer (NSCLC) is a global disorder, treatment options for which remain limited with resistance development by cancer cells and off-target events being major roadblocks for current therapies. The discovery of new drug…