Formulation and Evaluation of Tamsulosin Hydrochloride Sustained Release Capsules Using Pelletization Technique
Tamsulosin HCl is an αq-1 adrenergic receptor antagonist that is primarily used to treat benign prostatic hyperplasia (BPH), a disease defined by an enlarged prostate. The aim of this project is to develop, analyze, and compare the developed formulations to the innovator product (Flomax). The formulations were prepared by integrating Eudragit…
Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung…
Non-small cell lung cancer (NSCLC) is a global disorder, treatment options for which remain limited with resistance development by cancer cells and off-target events being major roadblocks for current therapies. The discovery of new drug…
Non-Uniform Drug Distribution Matrix System (NUDDMat) for Zero-Order Release of Drugs with Different…
A decrease in the drug release rate over time typically affects the performance of hydrophilic matrices for oral prolonged release. To address such an issue, a Non-Uniform Drug Distribution Matrix (NUDDMat) based on hypromellose was…
Development of an Orodispersible Film Containing Stabilized Influenza Vaccine
Most influenza vaccines are administered via injection, which is considered as userunfriendly. Vaccination via oral cavity using an orodispersible film (ODF) might be a promising alternative. To maintain the antigenicity of the vaccine…
Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and…
Although dry powder inhalers (DPIs) have attracted great interest compared to nebulizers and metered-dose inhalers (MDIs), drug deposition in the deep lung is still insufficient to enhance therapeutic activity. Indeed, it is estimated that…
Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via…
The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the…
Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly…
Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic potential, but with a low aqueous…
Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of…
Drug loading is an important parameter known to impact the release rate of a poorly soluble drug from an amorphous solid dispersion (ASD). Recent studies have shown that small increases in drug loading can dramatically reduce the drug…
Moisture barrier films for herbal medicines fabricated by electrostatic dry coating with ultrafine…
Barrier film coating is the most appropriate and widely used approach to protect solid dosages from moisture, particularly for water-sensitive drugs including herbal medicines. This study aims to produce the barrier film of a typical herbal…
Mucoadhesive Buccal Films for Local Delivery of Lactobacillus brevis
The aim of this work was to prepare mucoadhesive buccal films for local release of Lactobacillus brevis CD2, which shows interesting anti-inflammatory properties due to its high levels of arginine deiminase.…
The role of excipients and tablet matrix porosity on aspirin stability
Excipient-moisture interaction can be a critical attribute in determination of product stability. This study aimed to investigate influence of integrating excipients having different moisture interaction into moisture sensitive drug…
High shear seeded granulation: Its preparation mechanism, formulation, process, evaluation, and…
Seeded granulation is one of the recently adopted wet granulation techniques. The seeded granules consist of high-density core nuclei and low-density particles layered on the outside. It depends on various process and formulation factors.…
Development and Characterization of Water-in-Oil Microemulsion for Transdermal Delivery of Eperisone…
Background: Eperisone hydrochloride possesses short biological half-life due to first pass metabolism resulting in low bioavailability and short duration of response with toxic effects, ultimately limits its utilization for treatment of…
Development, Skin Targeting And Antifungal Efficacy Of Topical Lipid Nanoparticles Containing…
Considering the increased incidence of sporotrichosis and other fungal infections in rural and urban areas, and the limitations and adverse effects of oral itraconazole therapy, we studied nanostructured lipid carriers (NLC) as topical…
The Sound of Tablets during Coating Erosion, Disintegration, Deaggregation and Dissolution
This research aims to address a gap in our understanding of the mechanisms by which pharmaceutical tablets achieve highly reproducible and predictable drug release. The present industrial and regulatory practice is centred around tablet…
Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing…
Aim
It was the aim of this study to synthesize a phosphorylated emulsifier possessing a PEG-linker for establishment of a potent zeta potential changing system in self-emulsifying drug delivery systems (SEDDS).
Methods…
Evaluation of the stability and absorption of tacrolimus self-microemulsifying drug delivery system
Tacrolimus (FK506) is one of the most usually used drugs for organ transplantation. The poor bioavailability of FK506 is mainly caused by its low solubility, which can be improved by the application of self-microemulsifying drug delivery…
Design of self-nanoemulsifying system to enhance absorption and bioavailability of poorly permeable…
The aim of this study was to develop self-nanoemulsifying system (SNES) to improve the oral bioavailability of Aliskiren hemi-fumarate (AF). The solubility of AF in various oils, surfactants and, co-surfactants was studied to select the…
EXCiPACT Publishes a New Brochure
Regulators require excipient users to qualify their suppliers based on GMP/GDP audits. They have indicated that third party auditing of suppliers is acceptable if a creditable certification body issues certificates and audit reports by…
Pending Monographs for Excipients – Background & Guide
Do you want to use the USP Pending Monograph process? Or have you ever wondered what the USP Pending Monograph process is and how it works in detail? See our article explaining the PMP with a full overview or have a look at our summarizing…
Development of Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate
The objective of the present investigation was to understand the effect of sucrose acetate isobutyrate (SAIB) on abuse-deterrent properties (ADPs) of abuse-deterrent formulations (ADFs) based on Polyox™. SAIB would enhance ADPs of…
Polyelectrolyte–surfactant–complex nanoparticles as a delivery platform for poorly soluble drugs: A…
Previously, we reported on the surfactant cetylpyridinium chloride (CPC) as a crosslinker of alginate for the formation of stable polyelectrolyte–surfactant–complex nanoparticles. Here, we evaluate this system for increased solubility of a…
Nanoscale investigation of human skin and study of skin penetration of Janus nanoparticles
Janus nanoparticles (JNP) are innovative nanocarriers with an interesting pharmaceutical and cosmetic potential. They are characterized by the presence of a lipid compartment associated with an aqueous compartment delimited by a…
Evolution of the microstructure and the drug release upon annealing the drug loaded lipid-surfactant…
The present study investigates the drug release-governing microstructural properties of melt spray congealed microspheres encapsulating the drug crystals in the matrix of glyceryl behenate and poloxamer (pore former). The solid-state,…
The crucial effect of water and co-solvent on Liqui-Pellet pharmaceutical performance
Liqui-Pellet is considered to be the next generation oral dosage form. It is highly commercially feasible unlike its predecessor, liquisolid formulation. Liqui-Pellet uses Liqui-Mass system, allowing the formulation to overcome some of the…
Liquisolid pellets: Mixture experimental design assessment of critical quality attributes…
A Quality by Design approach was taken to assess the influence of several formulation parameters on critical quality attributes of liquisolid pellets (LPs) obtained by extrusion-spheronization. Two mixture experimental designs were used,…
Fluidized and Spouted Bed for the preparation of directly processable amorphous solid dispersions
One of the major challenges for modern formulation development is the increasing number of poorly water-soluble drugs. A common formulation approach to improve the solubility of those poorly soluble active ingredients is to formulate them…
Defining design space for optimization of escitalopram ultra-fast melting tablet using suspension…
In the pharmaceutical industry, the systematic optimization of formulation using Quality by Design (QbD) approach is economic, highly precise and ensures product quality. The current endeavor was aimed to prepare escitalopram ultra-fast…
Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in…
Since health care systems dedicate substantial resources to Alzheimer’s disease (AD), it poses an increasing challenge to scientists and health care providers worldwide, especially that many decades of research in the medical field revealed…
Model-dependent pharmacokinetic analysis of enalapril following the administration of novel…
Despite the legislative initiatives by the regulatory European medical agency (EMA) and the United States Food and Drug Administration Authority (FDA), an approved drug with child-appropriate dosage formulations are still absent for many…
Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening…
The major challenge of conventional lipid-based excipients (LBE) for drug delivery is their unstable solid state, affecting the stability of pharmaceutical product. Polyglycerol esters of fatty acids (PGFAs) are oligomeric hydroxyethers of…
Application of Supercritical Fluid Technology for Preparation of Drug Loaded Solid Lipid…
Small changes in pressure or temperature, close to the critical point, lead to large changes in solubility of supercritical carbon dioxide (CO2). Environmentally friendly supercritical CO2 is the most popular and inexpensive solvent which…
A novel approach to avoid capping and/or lamination by application of external lower punch vibration
Capping as well as lamination are two common problems, which affect the resulting product quality of the tablet. Usually, capping and lamination occur during or after tablet manufacturing, and may therefore influence follow-up processes…
Solubility Enhancement of Poorly soluble Drugs by using Novel Techniques : A Comprehensive Review
The primary aim of this review was to improve the solubility and Bioavailability of BCS Class-II drugs because of their low solubility and dissolution rate. Solubility is one of the imp parameter to achieve desired concentration of drug in…
FDA Advances Work Related to Cannabidiol Products with Focus on Protecting Public Health, Providing…
Statement from Commissioner of Food and Drugs - Food and Drug Administration
Stephen M. Hahn M.D. at March 05, 2020
Over the past year, the U.S. Food and Drug Administration has embarked on a comprehensive evaluation of cannabidiol…