Formulation and Evaluation of Tamsulosin Hydrochloride Sustained Release Capsules Using Pelletization Technique
Tamsulosin HCl is an αq-1 adrenergic receptor antagonist that is primarily used to treat benign prostatic hyperplasia (BPH), a disease defined by an enlarged prostate. The aim of this project is to develop, analyze, and compare the developed formulations to the innovator product (Flomax). The formulations were prepared by integrating Eudragit…
Solubility enhancement, formulation development, characterization and IVIVC of sustained release…
Ketoprofen granules were prepared by a relatively newer method, namely surfactant-assisted wet granulation (SAWG) approach using different concentrations (1-5%) of Soluplus®, polyethylene glycol (PEG) 6000, PEG 4000, poloxamers L6200 and…
Lipid-Based Gliclazide Nanoparticles for Treatment of Diabetes: Formulation, Pharmacokinetics,…
Introduction: Solid lipid nanoparticles (SLNs) are considered a promising system in enhancing the oral bioavailability of poorly water-soluble drugs; owing to their intrinsic ability to increase the solubility together with protecting the…
The protection effect of trehalose on the multinuclear microcapsules based on gelatin and high…
Drying of coacervates can cause various stresses which may lead to the damage of the outer layer membrane, aggregation, and poor rehydration properties. Gelatin/pectin coacervates prepared with addition of trehalose as cryoprotectant were…
Formulation and evaluation of hyaluronic acid-based mucoadhesive self nanoemulsifying drug delivery…
The present study was intended to develop a papain grafted S-protected hyaluronic acid-lithocholic acid co-block (PAP-HA-ss-LCA) polymeric excipient as an amphiphilic muco permeating stabilizer for targeting breast cancer epithelial cells…
Trehalose Conjugated, Catechin Loaded Polylactide Nanoparticle for Improved Neuroprotection against…
Intracellular/extracellular protein aggregation is linked to variety of neurodegenerative diseases. Current research focusses on identifying anti-amyloidogenic small molecules to inhibit such protein aggregation and associated cytotoxicity.…
Solid Lipid Nanoparticles
Recent advances in the development of nanocarriers have started a new era in Formulation Science. Among various nanoparticles, solid lipid nanoparticles (SLNs) offer an attractive carrier system to conventional colloidal carriers, such as…
Preparation and evaluation of captopril loaded gastro-retentive zein based porous floating tablets
In this study, gastro-retentive porous floating tablets of captopril based on zein are reported using l-menthol as a porogen. Tablets were prepared by the direct compression method. Removing of l-menthol through sublimation process generate…
Tefose® 63: Oil-in-water emulsifier for topical dosage forms
A multi-component system
Tefose® 63 is a physical mixture of three components: PEG-6 palmitostearate, ethylene glycol palmitostearate and PEG-32 palmitostearate. The exact quantity of each component has been carefully selected to obtain a…
Influence of cellulose and acetate-based polymers on the release of ciprofloxacin hcl from extended…
The objectives of the current study were to investigate the influence of different types and concentration of polymers on release of ciprofloxacin HCl as well as to formulate an extended release tablets of ciprofloxacin hydrochloride by…
Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at…
The therapeutic efficacy of orally administered drugs is often restricted by their inherent limited oral bioavailability. Low water solubility, limited permeability through the intestinal barrier, instability in harsh environment of the…
An investigation into the use of low quantities of functional additives to control drug release from…
The motivation of this study is to demonstrate the practicality of producing slow release and fast release products in a single-step hot melt extrusion (HME) process.
HPMCAS as the carrier material showed good potential in monolithic…
Developing sustained release tablets with Compritol® 888 ATO
Compritol® 888 ATO is a fine white powder, insoluble in water and organic solvents. It has no odor and no taste. It is used as lubricant, coating agent for the protection of sensitive drugs, in taste masking and as a matrix former in…
A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of…
Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was used to develop and produce nano co-crystals of 3TC and AZT. Equimolar amounts of 3TC dissolved…
Structure-Properties Relationship in the Evaluation of Alginic Acid Functionality for Tableting
The aim of this study is to investigate the relationship between the structural, molecular, and particulate properties of alginic acid and its functional characteristics in direct compression (tabletability, compressibility, elasticity,…
Digital UV/VIS imaging: a rapid PAT tool for crushing strength, drug content and particle size…
The Process Analytical Technology (PAT) and the Quality-by-Design (QbD) approaches can efficiently facilitate the shift to the desired continuous manufacturing and real-time release testing (RTRT). By this, it is vital to develop new,…
Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in…
Presented work focuses on the development of biodegradable polymer nanoparticles loaded with antibiotics as drug delivery systems deposited on electrospun scaffolds for tissue engineering. The innovative ciprofloxacin-loaded…
An evaluation of the Johanson model for roller compaction process development for a high dose API
Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation for high drug load formulations can be challenging due to flow issues and a high consumption of…
Encapsulation of an insulin-modified phosphatidylcholine complex in a self-nanoemulsifying drug…
Insulin is a dimeric hormone commonly administered by subcutaneous injection as the primary treatment for diabetes. This strategy, while efficient, does carry potential complications i.e., lipodystrophy with a decrease in absorption and…
Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the…
This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous…
Tab-in-Tab process
What is a Tab-in-Tab as a pharmaceutical dosage form? Only few articles about Tab-in-Tab pharmaceutical dosage forms can be found and specific tableting equipment is needed for such. It can be interesting as a novel approach for sustained…
Mechanistic understanding regarding the functionality of microcrystalline cellulose and powdered…
Powdered cellulose (PC) and microcrystalline cellulose (MCC) show considerable different behavior during wet-extrusion and spheronization. While MCC is an appropriate pelletization aid, PC is not suitable. The differences were explained by…
Influence of guest and host particle sizes on dry coating effectiveness: When not to use high mixing…
The effects of material stiffness, host and guest particle sizes, and mixing intensity on dry coating quality were investigated using a high-intensity vibrational mixer, using KCl, cornstarch, aluminum silicate and nano-sized silica. The…
Food Colors Progress of Color Provisions & Considerations for Upcoming CCFA – Webinar…
If you want to learn about the safety of food and drug colors and the current status of the JECFA and CODEX Committee on Food Additives (CCFA) evaluations of the colors for various food categories for listing in the international CODEX…
Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning
New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in…
3D printed opioid medicines with alcohol-resistant and abuse-deterrent properties
In the past decade, prescriptions for opioid medicines have been exponentially increasing, instigating opioid abuse as a global health crisis associated with high morbidity and mortality. In particular, diversion from the intended mode of…
Development and structural characterization of a novel nanoemulsion for oral drug delivery
The objective of this work has been to develop a template for the design and characterization of dried nanoemulsion (NE) for oral administration of hydrophobic compounds. A rational optimization of the nanosystem using an experimental…
Antisolvent precipitation of lipid nanoparticles in microfluidic systems – A comparative study
Microsystems offer promising possibilities to produce nanoparticles which can be used as carriers for poorly water-soluble active substances. The aim of the present study was to compare the preparation of lipid nanoparticles by…
Hot-melt extruded lipidic pellets for pediatric applications: An investigation of the effects and…
The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®)…
Quality by Design (QbD) approach to optimize the formulation of Multiunit Particulate System (MUPS)
The objective of this study was to develop and evaluate a MUPS formulation intended for treatment digestive tract ulcers.Work involves evaluation of different formulations of esomeprazole magnesium having enteric polymer and plasticizers to…
Three-dimensional aspects of formulation excipients in drug discovery: A critical assessment on…
Formulation/pharmaceutical excipients play a major role in formulating drug candidates, with the objectives of ease of administration, targeted delivery and complete availability. Many excipients used in pharmaceutical formulations are…
Problems during tablets manufacturing
Learn more about capping, lamination, picking and sticking as well as mottling, weight and hardness variations in tableting. All brought to to by Dr. Karim Maarif - founder of KMCD
Download the presentation here:…
Coronavirus highlights the $35 billion vaccine market. Here are the key players
The coronavirus outbreak is bringing attention to the fast-growing vaccine industry.
The vaccine market has grown sixfold over the past two decades, worth more than $35 billion today, according to AB Bernstein. The firm said the industry…
Comparison of two encapsulation processes to protect the commensal gut probiotic bacterium…
Anaerobic commensal gut bacteria are among the most promising future treatments for many diseases. Because of their sensitivity to oxygen and to the harsh conditions of the gut, few studies on formulations that deliver bacteria in a viable…
Evaluation Of Self-Emulsifying Drug Delivery Systems For Oral Insulin Delivery Using An In Vitro…
The gentle preparation and the functionalization potential of self-emulsifying drug delivery systems (SEDDS) make them an interesting formulation strategy for oral administration of peptide and protein (p/p) drugs.
A series of Kolliphor®…