A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
Evaluation Of Self-Emulsifying Drug Delivery Systems For Oral Insulin Delivery Using An In Vitro…
The gentle preparation and the functionalization potential of self-emulsifying drug delivery systems (SEDDS) make them an interesting formulation strategy for oral administration of peptide and protein (p/p) drugs.
A series of Kolliphor®…
Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality…
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. However,…
INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION…
As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated towards this novel granulation process. Binder suitability depends on binder effectiveness, which is affected by…
Benefits of Co-processed High-Functionality Excipients in a Continuous Direct Compression Process…
Continuous manufacturing offers significant advantages over conventional batch processing such as smaller equipment, less footprint and no need for upscaling experiments. With these benefits, come challenges as well. In a fully continuous…
Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of…
Gellan gum was chemically modified by the reaction with methacrylic anhydride to produce derivatives with 6, 14 and 49% methacrylation. The structure and substitution degrees of these derivatives were confirmed by 1H NMR- and…
Towards a molecular understanding of the impact of crystal size and shape on punch sticking
Punch sticking during tablet manufacturing is a common problem facing the pharmaceutical industry. Using several model compounds, effects of crystal size and shape of active pharmaceutical ingredients (API) on punch sticking propensity were…
Novel approach for overcoming the stability challenges of lipid-based excipients. Part 2:…
The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously…
Nanotechnology for Oral Drug Delivery 1st Edition
Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery…
Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening…
The major challenge of conventional lipid-based excipients (LBE) for drug delivery is their unstable solid state, affecting the stability of pharmaceutical product.
Polyglycerol esters of fatty acids (PGFAs) are oligomeric hydroxyethers…
Systematic implementation of quality-by-design (QbD) to develop NSAID-loaded nanostructured lipid…
The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release ocular drug delivery using a quality-by-design (QbD) approach. The BCS class II drug…
Download guidelines and get practical tips for successful formulation of sustained release tablets…
Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent:
Drug release from a Compritol® 888 ATO matrix is diffusion controlled and not driven by swelling and erosion. This facilitates simple product…
Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to…
Since psoriasis is an immuno-mediated skin disease, long-term therapies are necessary for its treatment. In clinical investigations, tacrolimus (TAC), a macrolide immunosuppressive inhibitor of calcineurin, arises as an alternative for the…
Development and Validation of an In‐Line API Quantification Method Using AQbD Principles Based on…
A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls. Quality by design principles that have…
Recent strategies and advances in the fabrication of nano lipid carriers and their application…
In last two decades, the lipid nanocarriers have been extensively investigated for their drug targeting efficiency towards the critical areas of the human body like CNS, cardiac region, tumor cells, etc. Owing to the flexibility and…
In-line particle size measurement and process influences on rotary fluidized bed agglomeration
In-line particle size measurement with a spatial filter velocimetry probe for process control was already carried out successfully in conventional fluidized bed coating and agglomeration but has not yet been investigated in rotary fluidized…
Poorly Water-Soluble Drugs and Formulation Strategy to Improve Oral Bioavailability
Poor water solubility of a drug is a tough and difficult task for researchers and pharmaceutical scientists during the formulation and development of dosage forms. Poor drug solubility often leads to inadequate and variable bioavailability.…
Investigation of powder flowability at low stresses: Influence of particle size and size…
At moderate stresses, shear cells are the preferred method of powder flow measurement. However, several industrial processes operate at low stresses, where the determination of unconfined yield strength by the shear cell technique may be…
Polymer/lipid interplay in altering in vitro supersaturation and plasma concentration of a model…
Supersaturation drug delivery system (SDDS) based on amorphous solid dispersion (ASD) is a widely used strategy to improve oral absorption of poorly water-soluble drugs by achieving a supersaturated state where drug concentration is…
Development of sustained release tablets with Compritol® 888 ATO – guidelines and practical…
Compritol® 888 ATO combines several advantages when used as a sustained release matrix agent. These will be explained and illustrated throughout this Guideline.
Download Gattefossé guidelines and get practical tips for successful…
Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug…
The presence of different excipient types/brands in solid oral dosage forms may affect product performance and drug bioavailability. Understanding the biopharmaceutical implications of superdisintegrant variability (changes in material…
Enhanced Solid-State Stability of Amorphous Ibrutinib Formulations Prepared by Hot-Melt Extrusion
One of the applications of Hot-Melt Extrusion (HME) is the stabilization of amorphous drugs through its incorporation into polymeric blends in the form of Amorphous Solid Dispersions (ASDs). In this study, HME was applied to solve a real…
Best practices in dealing with novel excipients
Novel excipients play a crucial role in bringing new, improved and safer drugs to the pharmaceutical market. There are however significant challenges in the development of innovative excipients, mainly because of the absence of globally…
EMDEX®: The Multi-Functional Excipient for Multiple Formulations
EMDEX® is a directly compressible, 100% water soluble, and lactose-free tablet binder. It is composed of a unique combination of glucose monohydrate and different polysaccharides derived from starch. When used in direct compression, EMDEX®…
Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality…
This study aimed to transfer a high shear granulation (HSG) process to a twin-screw granulation (TSG) process while maintaining equivalent dissolution profiles. Ibuprofen (IBP) was used as poorly soluble model drug. Granules were obtained…
SEPICLEAR™ 01 PPI – Solubilizer and antiaggregant
Poorly water-soluble drug candidates often emerge from contemporary drug discovery programs. Additionally, with the rising number of therapeutic biological drugs aggregation also become one of the major concerns in new drug developments.…
Continuous twin screw granulation: A complex interplay between formulation properties, process…
Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly gaining importance in pharmaceutical production. Since a large knowledge gap on the importance of…
Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant.…
Preparation and Evaluation of Controlled-Release Solid Dispersion Granules Containing a Poorly…
The study aim was to develop controlled-release, solid dispersion granules containing a poorly water-soluble drug, Hydrated Silicon Dioxide (HSD), and Polyvinylpyrrolidone (PVP), and to elucidate the mechanism underlyingsustained release…
Roller compaction: Infrared thermography as a PAT for monitoring powder flow from feeding to…
Roller compaction is a continuous dry granulation process, in which powder is compressed by two counter-rotating rollers. During this process, the powder feeding to the compaction zone has a significant effect on product quality. This work…
Data on the drug release profiles and powder characteristics of the ethyl cellulose based…
Ethyl cellulose (EC) based microparticles (MPs) could provide sustained release for Huperzine A. The drug release mechanism of MPs was exploited to achieve an ideal drug release profile. We previously found that the wettability of MPs…
Monitoring lubricant addition in pharmaceutical tablet manufacturing through passive vibration…
In tablet manufacturing, a lubricant is added in a tumbling mixer prior to compression to ensure that the tablet is ejected smoothly without sticking or breakage. Control and monitoring of this process is critical as process parameters can…
Multi-functional chitosan polymeric micelles as oral paclitaxel delivery systems for enhanced…
Chitosan is widely used as a permeation enhancer for oral drug delivery, although its drawbacks include a limited enhancement of drug bioavailability and an inability to form micelles.
In this study, we designed a novel chitosan derivative…
Safety Assessment of Excipients (SAFE) for Orally Inhaled Drug Products
The development of new orally inhaled drug products requires the demonstration of safety which must be proven in animal experiments. New in vitro methods may replace, or at least reduce, these animal experiments provided they are able to…
PVA in Sustained Release Matrix Tablets – Wet Granulated vs Direct Compression – Poster
Polymer-based long-acting matrix tablets are often used to ensure patient compli- ance and API efficacy of orally applied drugs. Increasingly, polyvinyl alcohols (PVAs) are used as hydrophilic, swellable and erodible matrices in such…