A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
The role of Roquette’s KLEPTOSE® HPβCD in the fight against coronavirus
Geneva, IL (USA), February 11, 2020 – Roquette has recently identified that its KLEPTOSE® hydroxypropyl beta-cyclodextrins (HPβCD) product, a functional excipient and a specialty active pharmaceutical ingredient (API), may be effective to…
Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes:…
The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes.…
Amphiphilic hyperbranched polyester coated rod mesoporous silica nanoparticles for pH-responsive…
Rod-like mesoporous silica nanoparticles with pH-responsive amphiphilic hyperbranched polyester shells were prepared for doxorubicin (DOX) delivery. First, rod-shaped mesoporous silica nanoparticles (MSNs) were obtained, then hydrophobic…
Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved…
Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low solubility and intestinal glucuronidation. The nano-lipid carriers are characterized by small particle size,…
Design, Optimization and Characterization of Nanostructured Lipid Carriers of Raloxifene…
Raloxifene Hydrochloride (RXL), a BCS class II drug, is used for the treatment of invasive breast cancer and osteoporosis in post menopausal women. Even though the drug is highly efficient, it shows poor bioavailability of 2% when…
Gelatin nanoparticles for NSAID systemic administration: Quality by design and artificial neural…
The present study evaluates the preparation of systemic administrated NSAID gelatin nanoparticles with the aid of quality by design and artificial neural networks (ANNs). Specifically, two different preparation techniques (i.e.…
Bile acid transporter mediated STC/Soluplus self-assembled hybrid nanoparticles for enhancing the…
The nano-particulate system for oral delivery faces a big challenge across the gastrointestinal bio-barriers. The aim was to explore the potential applications of bile acid transporter mediated the self-assembled hybrid nanoparticles…
Simplification of Fused Deposition Modeling 3D-Printing Paradigm: Feasibility of 1-step Direct…
Direct powder three-dimensional (3D)-printing (DPP) of tablets to simplify fused deposition modelling (FDM) was explored. The FDM paradigm involving hot-melt extrusion for making 3D-printable drug-loaded filaments as intermediate products…
Polymers for Extrusion‐Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process…
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of ʹone size fits for allʹ. Using 3D printing, it is…
CBD loaded microparticles as a potential formulation to improve paclitaxel and doxorubicin-based…
Cannabidiol (CBD) has emerged as a potential agent for breast cancer management.
In this work, the potential use of cannabidiol in solution (CBDsol) and encapsulated in polymeric microparticles when combined with paclitaxel (PTX) and…
A material-saving and robust approach for obtaining accurate out-of-die powder compressibility
Density is an important material property for evaluating, or developing a tablet formulation. In-die compressibility data can be obtained using a small amount of powder with the help of a compaction simulator. However, compacts undergo…
How to measure coating thickness of tablets: Method comparison of optical coherence tomography,…
Film coating of pharmaceutical dosage forms, such as tablets and pellets, can be used to tailor the drug release profile. With that regard, a uniform coating thickness of a single tablet (intra-tablet), all tablets (inter-tablet) and…
Development of a Novel Nanoemulsion Formulation to Improve Intestinal Absorption of Cannabidiol
Cannabidiol (CBD) is highly lipophilic, and its oral bioavailability is known to be very low in humans. In this study, we developed a novel nanoemulsion preparation of CBD (CBD-NE) to improve the poor solubility and absorption of CBD. The…
Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model
Cannabidiol (CBD) and the potential benefit is the current hot topic. Just found this publication by the group of Elka Touítou Hebrew University of Jerusalem from 2003. She will hold at this years PBP Worldmeeting the presentation:…
USP Comment to FDA Proposed Novel Excipient Review Program
The United States Pharmacopeia (USP) appreciates the opportunity to provide comments on a potential FDA novel excipient review program. USP is supportive of a novel excipient review program. Establishing new pathways for the development and…
A model to simultaneously evaluate the compressibility and compactibility of a powder based on the…
The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously. Eighteen types of pharmaceutical excipients were studied via direct compaction. The model was established as CR…
Easy cleaning of hot melt extrusion
More than half of New Chemical Entities (NCEs), which were developed recently, tend to show high crystallinity and poor solubility in water. Solid dispersion is a technique to improve the solubility and bioavailability of these NCEs.…
Influence of compression at elevated temperature on the compactibility of thermo-mechanically…
Hot-melt extrusion (HME) is increasingly applied in the pharmaceutical industry for the formulation of solid dispersions of drugs with improved solubility and release. However, tableting of milled extrudates may present problems due to…
Aspects to Consider in Drug Development of Age‐Appropriate Formulations for Children
Oral drug administration to pediatric patients is characterized by a lack of age‐appropriate drug products and the off‐label use of medicines. However, drug administration practices at hospital wards is a scarcely studied subject.
The aim…
Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug‐cyclodextrin…
Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
Despite the increasing interest in pharmaceutical use of mesoporous silica, there is still only limited knowledge on mechanisms of pore loading and subsequent drug desorption and release. Hence the aim of this work was to address the…
Microstructural characterization of carrier-based dry powder inhalation excipients: Insights and…
The growing interest in development of dry powder inhalation (DPI) products raises a need for development of standard testing methods and specifications for DPI excipients. The pharmaceutical industry, meanwhile, yet lacks compendial…
Improvement water-solubility of ellagic acid for use as an antimalarial drug through oral…
Ellagic acid (EA) is a polyphenolic compound, classed as a BCS IV drug, having anti-plasmodial activity on plasmodium-infected cell cultures. However, this class of molecules has a low oral bioavailability. The aim of our study is to…
Human volunteer, in vitro, and molecular level evaluation of an optimized taste-masked…
For the first time, isoniazid (INH) bitterness value, threshold, and sensitivity (low, moderate, high, and extremely high) was determined in six human volunteers. INH demonstrated a large range in bitterness sensitivity.
The current work…
Advantages and disadvantages of Hot Melt Coating
Advantages of Hot Melt Coating (HMC)
One advantage for the pharmaceutical industry is the simplification of complex dosage schemes, as several active ingredients can be combined, even those that cannot normally be combined. As the…
Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: Effect…
The objective of the study was to assess the effect of enhanced mucoadhesion of a cationic mucoadhesive nanostructured lipid carrier (NLC) on its ocular disposition after topical administration. The NLC was made mucoadhesive by surface…
In-silico discovery and experimental verification of excipients for biologics
Protein-based pharmaceuticals such as monoclonal antibodies are the fastest growing class of therapeutic agent. As with all protein therapeutics, antibody aggregation must be avoided during production, storage and use. With recent advances…
Fabrication of efavirenz loaded nano-formulation using quality by design (QbD) based approach:…
Quality by design (QbD) approach was practically applied in fabrication of nanostructured lipid carrier (NLC) encapsulating efavirenz (EF) to ensure the quality in product. Initially, risk factors were categorised based on risk priority…
Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet…
Ligustrazine (or Tetramethylpyrazine, TMP) is an active pharmaceutical ingredient that faces the challenges of bitter taste and low oral bioavailability by the commercial phosphate salt (TMP-Pho). We tackled these challenges by forming…
Towards an Improved Understanding of Drug Excipient Interactions to Enable Rapid Optimization of…
Suspensions of drug nanoparticles known as nanosuspensions have emerged as a successful enabling formulation approach for poorly soluble drug candidates. These nanoparticles typically require stabilization with specific polymer or…
Non-destructive dose verification of two drugs within 3D printed polyprintlets
Three-dimensional printing (3DP) is a revolutionary technology in pharmaceuticals, enabling the personalisation of flexible-dose drug products and 3D printed polypills (polyprintlets). A major barrier to entry of this technology is the lack…
The functionality of Hot Melt Coating
Guidance for an excellent Hot Melt Coating
Part 2 in the series of 3 articles
In order to reduce the problems of other solvent-based coating processes, such as time and cost intensity, the active ingredient coating by means of Hot Melt…
Semisolid-filled Capsules of Carvedilol for Improving Dissolution Behaviour
The present investigation was aimed at enhancing the dissolution properties of carvedilol, a poorly water-soluble drug using a combination of solid dispersion and semisolid-filled capsule. The use of lauroyl polyoxyl-6 glycerides as a…
Reimagine ODT
SuperTab® 50 ODT is a new product within DFE Pharma’s portfolio. It provides a solution for orodispersible formulations, helping to deliver medication to pediatrics and geriatric patients, or to those who suffer from Dysphagia.…