A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
Phase behavior of pharmaceutically relevant polymer/solvent mixtures
In the pharmaceutical industry, polymers are used as excipients for formulating poorly water–soluble active pharmaceutical ingredients (APIs) in so-called “amorphous solid dispersions” (ASDs). ASDs can be produced via solvent-based…
Why Hot Melt Coating?
Disadvantages of solvent-based coatings and why alternatives are needed
The coating of active substances requires the suspension of the auxiliary substances in a solvent. This mixture is then applied to the active ingredient particles. If…
Taste Masking Coating of Mini-Tablets with Cellulose Derivatives: Formulation and Analytical…
You wonder how to improve tablets swallowability and taste? Look at the poster describing solutions with HPMCAS (Shin-Etsu AQOAT®) and L-HPC from their originator, Shin-Etsu.
Download the Poster as a pdf here: Taste Masking Coating of…
Polymers and hydrogels to deter drug abuse – Engineering Drug Delivery Systems
In pharmaceutical formulations, polymers are traditionally and commonly used as viscosifier, binder, gelling agent, suspending agent, protective agent, controlled-release medium, adhesive, and packaging material.
With the development of…
Novel Excipients: New Hope for Therapeutic Innovations
Article By Dr. Catherine Sheehan - Senior Director of Science – Excipients at the United States Pharmacopeial Convention
With significant innovations in pharmaceuticals, including biologic drugs and treatments for rare diseases, the need…
How to register co-processed excipients – MEGGLE Excipients & Technology
Co-processed Excipients:
Drug approval process | Compendial vs. Novel Excipients
Common Technical Documentation Format – CTD
Throughout a drug approval process a team of drug regulatory experts needs to compile mandatory documentation,…
News Release – Pharmatrans at IPEC 2020
Book a meeting with Pharmatrans at IPEC annual forum to know more about new DICOM SANAQ Co-Processed platform
Allschwil, Switzerland: – Pharmatrans Sanaq (Pharmatrans) will be a leading presence at the upcoming IPEC Europe Forum excipients…
A systematic evaluation of poloxamers as tablet lubricants
Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to…
Interfacial bonding in formulated bilayer tablets
To take full advantage of the drug delivery benefits offered by bilayer tablets, the common issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This work seeks to characterize the effects of composition in…
Novel Approach for Overcoming the Stability Challenges of Lipid-Based Excipients. Part 2:…
The application of hot melt coating (HMC) as an economic and solvent-free technology is restricted in pharmaceutical development, due to the instable solid-state of HMC excipients resulting in drug release instability. We have previously…
Roller compaction
Roller compaction is the main technique employed in dry granulation.
Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally…
Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose…
The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were…
Micronization and Agglomeration: Understanding the Impact of API Particle Properties on Dissolution…
The study aims to investigate the effect of agglomeration on micronized model active pharmaceutical ingredient (API) and to unravel the influence of API agglomerate strength on dissolution and permeation.
Methods
Model API (micronized…
Olanzapine, improvement of biopharmaceutical performance in solid dosage form
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia.
It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive…
Multifunctional Nanocarriers for Lung Drug Delivery
Nanocarriers have been increasingly proposed for lung drug delivery applications.
The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of…
Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and…
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and…
Benznidazole Self-Emulsifying Delivery System: A Novel Alternative Dosage Form For Chagas Disease…
Benznidazole (BZ) tablets are a unique form of treatment available for treating Chagas disease. Development of a liquid formulation containing BZ easy to administer orally for the treatment of paediatric patients, particularly for newborns…
Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid…
Drug delivery of poorly soluble drugs in form amorphous solid dispersions (ASDs) is an appealing method to increase in vivo bioavailability. For rational formulation design, a mechanistic understanding of the impact of surfactants on the…
Continuous twin screw granulation: impact of binder addition method and surfactants on granulation…
Despite the recent commercialization of several drug products manufactured through continuous manufacturing techniques, knowledge on the formulation aspect of these techniques, such as twin screw wet granulation, is still rather limited.…
Oral formulation strategies to improve the bioavailability and mitigate the food effect of…
Abiraterone acetate, marketed as Zytiga®, is an antiandrogen medication used in the treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated with several oral delivery challenges. Its low solubility and high…
FDA and Cannabis: Research and Drug Approval Process
The FDA understands that there is increasing interest in the potential utility of cannabis for a variety of medical conditions, as well as research on the potential adverse health effects from use of cannabis.
To date, the FDA has not…
Polyester based polymeric nano and microparticles for pharmaceutical purposes: A review on…
The novel polymeric particulate systems show high potential in their clinical effectiveness.
Nevertheless, many of the drug delivery systems developed in the research laboratories have not found their way to clinics. The lack of…
Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation…
Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal imaging during…
Optimization and tracking of coating processes of pellets with polyvinylpyrrolidone solutions in an…
The purpose is to present the application of the acoustic levitation as a model system for a coating process with non-spherical and light particles in the fluidized bed reactor.
An acoustic levitator has been used to track a pellet in a…
Development of Non-Amorphous Solid Dispersions for Poorly-Soluble Drugs Using a Novel Excipient and…
Drug solubility is a persistent challenge in pharmaceutical product development. The objective of this research is to develop a formulation/processing strategy by means of a biodendrimeric solid dispersion (BDSD) platform, for increasing…
The Importance of Amorphous Stability: Mesoporous Silica for Poor Glass Formers – Webinar
Manufacturing Strategies Webinar Series
The Importance of Amorphous Stability: Mesoporous Silica for Poor Glass Formers
This webinar will discuss the theory of amorphous stabilization followed by a discussion on mesoporous silica as an…
Emerging role of nanosuspensions in drug delivery systems
Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility.
By virtue of the submicron particle size and distinct physicochemical…
Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy
Disulfiram (DSF) is an FDA-approved drug that has been repurposed for cancer treatment.
It showed excellent anticancer efficacy in combination with copper ions (Cu). Several active clinical trials testing the anticancer efficacy of DSF…
Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system…
Lipid nanoemulsions are attractive drug delivery systems for lipophilic drugs.
To produce nanoemulsions with droplets of very small diameter (<100 nm), we investigated thermotropic phase transitions as an alternative to the standard…
Liquisolid Pellets and Liqui-Pellets Are Not Different
Our research group has pioneered the development of liquisolid pellets as a new drug delivery system targeting at the improvement of the dissolution rates of poorly water-soluble drugs, combining the technological and biopharmaceutical…
Dissolution Enhancement of Carbamazepine using Twin-screw Melt Granulation
The current study explored the twin-screw melt granulation (TSMG) as a potential technology for the water solubility enhancement of BCS (biopharmaceutical classification system) class II drugs.
As a model drug, carbamazepine (CBZ) was…
Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial…
Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability.
Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development…
Solubility and Bioavailability Enhancement of Oridonin: A Review
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory eects.…
A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine
Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection‐spray drying method. The response surface method was used to optimize formulation to…