Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically…
Background: Depressive disorders contribute to an excruciating global mental health burden. Recently, there has been a great shift in interest towards substances with psychedelic potential as treatment for patients with resistant forms of…
Investigating the prilling/vibration technique to produce gastric-directed drug delivery systems for…
Prilling/vibration technique to produce oral microcapsules was explored to achieve local delivery of misoprostol (MIS), a prostaglandin E1 analogue indicated for the treatment of gastric-duodenal ulcers, at the gastric mucosa. To improve…
Effect of lipid composition on RNA-Lipid nanoparticle properties and their sensitivity to thin-film…
A library of 16 lipid nanoparticle (LNP) formulations with orthogonally varying lipid molar ratios was designed and synthesized, using polyadenylic acid as a model for mRNA, to explore the effect of lipid composition in LNPs on (i) the…
TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis…
Erastin is the most classical small molecular ferroptosis inducer but its clinical application is hindered due to its poor solubility. Nanotechnology has been used to improve ferroptosis inducer erastin’s solubility. The recently reported…
Ensuring the quality of 3D printed medicines: Integrating a balance into a pharmaceutical printer…
Abstract
Semi-solid extrusion (SSE) 3D printing has great potential to be integrated in a clinical setting, with the use of pre-filled and disposable pharma-ink syringes meeting regulatory good manufacturing practice (GMP) requirements.…
Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils: Applications for…
Ingestible self-configurable proximity-enabling devices have been developed as a non-invasive platform to improve the bioavailability of drug compounds via swellable or self-unfolding devices. Self-unfolding foils support unidirectional…
Non-invasive peptides delivery using chitosan nanoparticles assembled via scalable microfluidic…
The delivery of peptides via non-invasive administration routes remains a challenge to be addressed. In this regard, chitosan nanoparticles (CS NPs) have shown promise. However, their current batch preparation methods (ionotropic gelation,…
Palatability and Stability Studies to Optimize a Carvedilol Oral Liquid Formulation for Pediatric…
Abstract
Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an “off-label” treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its…
Material-Sparing Feasibility Screening for Hot Melt Extrusion
Abstract
Hot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are…
A dataset of formulation compositions for self-emulsifying drug delivery systems
Abstract
Self-emulsifying drug delivery systems (SEDDS) are a well-established formulation strategy for improving the oral bioavailability of poorly water-soluble drugs. Traditional development of these formulations relies heavily on…
Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements
Abstract
In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary delivery were investigated, as well as the…
3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in…
Abstract
The incidence of Inborn Error of Intermediary Metabolism (IEiM) diseases may be low, yet collectively, they impact approximately 6–10% of the global population, primarily affecting children. Precise treatment doses and strict…
Data-driven development of an oral lipid-based nanoparticle formulation of a hydrophobic drug
Due to its cost-effectiveness, convenience, and high patient adherence, oral drug administration normally remains the preferred approach. Yet, the effective delivery of hydrophobic drugs via the oral route is often hindered by their limited…
Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method
The pharmaceutical industry has highlighted particle-size reduction via preparing aqueous suspensions containing nano- or submicron drug particles. Owing to the risk of agglomeration and complications during the manufacturing of solid…
Effect of the drying type on the properties of granules and tablets produced by high shear wet…
Although high shear mixers can represent a single-pot process, separate drying equipment is commonly employed. Limited literature exists on the use of a heating jacket coupled with a vacuum pump typically used in a single-pot setup, so this…
Development of rapidly soluble mebendazole nanosuspension for colorectal cancer
Mebendazole (MBZ) has been proven as a repurposing molecule against colorectal cancer. Unfortunately, its clinical application is constrained by its extremely poor solubility and bioavailability. The aim of the current work was to augment…
PEARLITOL® 200 GT Mannitol: Harnessing the Potential of Higher Active Ingredient Content for…
INTRODUCTION
Mannitol is the first intention excipient for oral solid forms, designed for APIs having stability problems. Mannitol is not hygroscopic and presents a high chemical stability; therefore, it is considered compatible with…
Freeze-Drying of Encapsulated Bacteriophage T4 to Obtain Shelf-Stable Dry Preparations for Oral…
Therapeutic application of bacterial viruses (phage therapy) has in recent years been rediscovered by many scientists, as a method which may potentially replace conventional antibacterial strategies. However, one of the main problems…
Buccal delivery system of active pharmaceutical ingredients-ionic liquid (API-IL): Effects of API-IL…
Ionic liquid (IL) salt of active pharmaceutical ingredient (API) represents a promising formulation strategy to address low drug solubility and polymorphism prevalent in API solid crystals. The present work developed for the first time a…
A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining…
Objective:
This study aimed to develop a holobiont tablet with rapid dispersibility to provide regulation of the microbiota, virucidal activity, and skin barrier protection.
Methods:
A 23 factorial experiment was planned to define the…
Formulation and Characterization of Bilastine Oral Disintegrated Tablets Using Natural and Synthetic…
Bilastine (BLS) is a second-generation H1- antihistamine that is approved recently for the symptomatic treatment of chronic urticaria. The present investigation was to develop oral disintegrating tablets of BLS to produce a fast onset of…
Correlating mechanical and rheological filament properties to processability and quality of 3D…
Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet…
Lecithin Microemulsions as Drug Carriers
The paper describes examples of microemulsions based on a well-known biocompatible surfactant, lecithin, and the possibilities of their use as drug carriers. The main problem encountered when developing lecithin microemulsions is the search…
Nanoemulsions and Solid Lipid Nanoparticles with Encapsulated Doxorubicin and Thymoquinone
Nanoemulsions (NEs) and solid lipid nanoparticles (SLNs) are promising drug delivery systems. In this work, paraffin oil NEs and stearic acid SLNs stabilized with Tween 60 and Span 60 have been studied. NEs with an average droplet diameter…
Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
The upper airways represent the point of entrance from where Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection spreads to the lungs. In the present work, α-tocopheryl-polyethylene-glycol succinate (TPGS) micelles loaded…
Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100
Purpose
The purpose of this study was to investigate the effect of tartaric acid on the maintenance of dipyridamole supersaturation using Eudragit E100 as a carrier.
Methods
The solubility of dipyridamole was determined in a buffer…
Case Study PEARLITOL® 200 GT Mannitol: A Tool to Formulate Mini Tablets as a Compliant and Flexible…
PURPOSE
Mini tablets are a multiple unit dosage form with a size of less than 3.0 mm in diameter with great flexibility to deliver appropriate doses to the pediatric age group. They can be given in different numbers, according to dosage…
Successful Formulation Window for the design of pharmaceutical tablets with required mechanical…
Abstract
Pharmaceutical tablet formulations combine the active ingredient with processing aids and functional components. This paper evaluates compressibility based predictive models for binary and ternary formulations to establish an…
Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using…
Abstract
Objective: Florfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability.
Significance: Here in, we aimed to explore the applicability of fast disintegrating tablets compressed from…
Effect of Croscarmellose Sodium in Sustained Release Layer of Valsartan in Bilayer Tablet with…
The aim of the study was to design and evaluate bilayer tablets of clopidogrel as immediate release and quick relief and valsartan for sustained release and check the effect of croscarmellose sodium (2%) in Carbopol for sustained release…
Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active…
Abstract
Amphiphilic cyclodextrin derivatives (ACD) are useful starting materials for nanomedicines; however, their synthesis using enzymatic catalysis is unsatisfactory. This work focuses on a robust alternative pathway using mineral base…
Development and characterization of a spray-dried inhalable ternary combination for the treatment of…
Cystic fibrosis (CF) is an inherited lung disease characterised by the accumulation of thick layers of dried mucus in the lungs which serve as a nidus for chronic infection. Pseudomonas aeruginosa is the predominant cause of chronic lung…
Development of a New Jelly Coating Technology (Oral Jelly Coating) to Improve Prescribed Medication…
Oral drug delivery is currently the gold standard in the pharmaceutical industry, regarded as the safest, most convenient and most economical method of drug delivery with the highest patient compliance . Among oral formulations, tablets and…
Significant Progress in Improving Atorvastatin Dissolution Rate: Physicochemical Characterization…
Atorvastatin (ATV) is a first-line drug for the treatment of hyperlipidemia. This drug presents biopharmaceutical problems, partly due to its low solubility and dissolution rate. In this work, nanocrystals of ATV stabilized with Tween 80®…