Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Formulation, optimization and in vitro evaluation of nanostructured lipid carriers for topical…
This work was aimed to formulate topical Apremilast loaded nanostructured lipid-carriers (NLCs) for the management of psoriasis.
Psoriasis is a widespread skin condition considered to be a Th1 autoimmune skin disease and characterized by…
Co-processed excipients for direct compression of tablets
Tablets are the most frequently employed dosage form. Their advantage lies in their availability, easy administration, good stability, and low price. The easiest technology to produce tablets is direct compression, even though the use of…
Solid Lipid Nanoparticles: A Multidimensional Drug Delivery System
The development of drug delivery carriers is often very challenging, due to the physicochemical properties of the drug such as poor solubility, low permeability, and short half-life. Development of colloidal delivery systems has introduced…
A model to simultaneously evaluate the compressibility and compactibility of a powder based on the…
The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously.
Eighteen types of pharmaceutical excipients were studied via direct compaction. The model was established as…
Improving Bioavailability of Vitamin A in Food by Encapsulation: An Update
Vitamin A is an obligatory micronutrient for healthy human life as it cannot be synthesized de novo and has to be acquired from dietary sources.
The poor water solubility and susceptibility against photochemical degradation make vitamin…
Continuous twin screw granulation: Influence of process and formulation variables on granule quality…
In recent years, continuous manufacturing techniques, such as twin screw wet granulation, have gained significant momentum.
Due to the large diversity of the (model) formulations and equipment, it is often difficult to generalize…
High purity excipients – A Simple Solution to a Complex Problem
A drug-dev.com article by Dr. William Small and Arsalan Khan
It wouldn’t come as a surprise to anyone that active pharmaceutical ingredients (APIs) come in a wide variety. Small molecule, large molecule, peptide, monoclonal antibody,…
Formulation, optimization and in vitro evaluation of nanostructured lipid carriers for topical…
This work was aimed to formulate topical Apremilast loaded nanostructured lipid-carriers (NLCs) for the management of psoriasis.
Psoriasis is a widespread skin condition considered to be a Th1 autoimmune skin disease and characterized by…
Formulation Development and In Vitro Evaluation of Curcumin-Loaded Solid Self-Nanoemulsifying Drug…
Objective: Cancer is the deadliest disease affecting the life of the people all around the world. Colon cancer is the cancer which is affecting the colon region it is the last part of the gastrointestinal tract which is mainly responsible…
Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs…
Modular Web Converting – TDS and ODF Machines
RCA Bignami Srl was founded in 1994 and after many years of intense activities, experience and continuous innovation, today is a leading corporation in the industry. The company plays an important role not only in the rotary dies and…
Systematic screening of pharmaceutical polymers for hot melt extrusion processing: a comprehensive…
Pharmaceutical research, whether industrial or academic, has attempted to adopt approaches most efficient for the development of innovations.
With the abundance of literature and growth of modern techniques available to minimize the…
Co-encapsulation of Docetaxel and Thymoquinone in mPEG-DSPE-Vitamin E TPGS-Lipid nanocapsules for…
Rationally designed combination nano-therapy approaches have emerged as a promising strategy for resistant breast cancer treatment.
This research reports the combination of Docetaxel (DTX) and Thymoquinone (THQ)…
The Comeback of Small Molecules?
Innovation drives progress in the development of new drugs and therapeutic biological products.
48 new drugs and biological products were approved by the FDA last year, which means new treatment options for patients and…
Design and Characterization of Cyclosporine A-Loaded Nanofibers for Enhanced Drug Dissolution
Despite widespread use as an immunosuppressant, the therapeutic efficacy of the undecapeptide cyclosporine A (CyA) is compromised when given by the oral route because of the innate hydrophobicity of the drug molecule, potentially leading to…
Phytosome-Nanosuspensions for Silybin-Phospholipid Complex with Increased Bioavailability and…
Silybin, a natural compound for treating liver disease, has been shown to provide diverse biological activities such as anticancer, antioxidant and hepatoprotective.
However, it is still challenging to develop silybin product due to its…
Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy
Cannabis has been used in pain management since 2900 BC. In the 20th century, synthetic cannabinoids began to emerge, thus opening the way for improved efficacy. The search for new forms of synthetic cannabinoids continues and, as such, the…
Prilling of API/fatty acid suspensions: screening of additives for drug release modification
Current study screened additives which could modify the drug release from prills made of an active pharmaceutical ingredient/fatty acid (API/FA) suspension, without negatively influencing the processability and/or stability of the…
Protective Effect of Saccharides on Freeze-Dried Liposomes Encapsulating Drugs
The production of freeze-dried liposomes encapsulating drugs is considered a key challenge since the drugs are prone to leakage.
The aim of this work was to study the effect of different saccharides on preserving the stability and drug…
Powder flow and mixing in different tablet press feed frames
Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets.
From Quality by Design (QbD) perspectives the feed…
Fast Dissolving Tablets – An Updated Review
Fast dissolving tablets (FDTs) is one of the most widely accepted and popular dosage form, especially for paediatric and geriatric patients. Conventional solid dosage forms like tablets and capsules are facing the problems like difficulty…
Globular protein stabilized nanoparticles for delivery of disulfiram: fabrication, characterization,…
Disulfiram (DSF), an FDA-approved anti-alcoholic drug, has recently shown that it possesses anti-cancer effects. However, DSF is hydrophobic in nature with less stability. Therefore, new approaches are required for the effective delivery of…
Investigation of the effects of particle size on fragmentation during tableting
Particle size is a critical parameter during tablet production as it can impact tabletability, flowability, and dissolution rate of the final product.
The purpose of this study was to investigate the effect of initial particle size on…
Spray-dried liposomes: A study of the effect of carbohydrate carrier and concentrations on liposome…
Background and objective: Dry powder inhalation provide many promising features for
drug delivery to the pulmonary system, such as localization of drug within the lungs, drug
retention in the respiratory tract, and reduced systemic…
Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and…
Formulation and Evaluation of Fast Dissolving Tablet of Montelukast by using Co-processed Excipients
The current research work was aimed with an objective of formulation development of fast dissolving tablet of montelukast by using co-processed excipient and to evaluate the effect of co-processed excipient over physical mixture of same…
The most significant FDA approvals of the decade (2010-2019)
From innovative leaps in cancer diagnosis and treatment to the growing force of artificial intelligence in aiding medical discovery, the 2010s was a ground-breaking decade for the life science industry. We have seen the steady rise of…
The most significant FDA approvals of the decade (2010-2019)
From innovative leaps in cancer diagnosis and treatment to the growing force of artificial intelligence in aiding medical discovery, the 2010s was a ground-breaking decade for the life science industry. We have seen the steady rise of…
Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery
This review is an extensive evaluation and essential analysis of the design and formation of
hydrogels (HGs) for drug delivery. We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis…
Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery
This review is an extensive evaluation and essential analysis of the design and formation of hydrogels (HGs) for drug delivery.
We review the fundamental principles of HGs (their chemical structures, physicochemical properties, synthesis…
Formulation of Ketoconazole Nanocrystal-Based Cryopellets
Commercial development of nanosuspensions for oral drug delivery generally involves a drying step which aims to generate a stable product that rapidly releases the nanocrystals once rehydrated and can be easily processed into a final dosage…
Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression…
The development of orodispersible tablets (ODTs) for poorly soluble and poorly flowable drugs via direct compression is still a challenge.
This work aimed to develop ODTs of poorly soluble drugs by combining cyclodextrins that form…
Evaluation of an Immediate-Release Formulation of Hydroxychloroquine Sulfate with an Interwoven…
Hydroxychloroquine sulfate (HCQ) is a quinoline used for the prevention and treatment of uncomplicated malaria, lupus erythematosus, and rheumatoid arthritis.
For each indication, HCQ is an option for treatment of pediatric and juvenile…
Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs
Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals.
The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to…