A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression…
The development of orodispersible tablets (ODTs) for poorly soluble and poorly flowable drugs via direct compression is still a challenge.
This work aimed to develop ODTs of poorly soluble drugs by combining cyclodextrins that form…
Evaluation of an Immediate-Release Formulation of Hydroxychloroquine Sulfate with an Interwoven…
Hydroxychloroquine sulfate (HCQ) is a quinoline used for the prevention and treatment of uncomplicated malaria, lupus erythematosus, and rheumatoid arthritis.
For each indication, HCQ is an option for treatment of pediatric and juvenile…
Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs
Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals.
The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to…
Review on Tablet in Tablet techniques
Among all available dosage form, tablet is most widely used because of its stability and patient acceptability. The better aesthetic quality like color, texture, mouth feel, and taste masking depended on film and sugar coatings, so the…
Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a…
In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug release, and stomach degradation of active components of Compound Danshen in conventional…
Patient Centric Pharmaceutical Drug Product Design—The Impact on Medication Adherence
Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients.
Interventions for improving adherence need to consider the…
3D Printing in Pharmaceutical Sector: An Overview
The pharmaceutical industry is moving ahead at a rapid pace. Modern technology has enabled the development of novel dosage forms for targeted therapy. However, the fabrication of novel dosage forms at industrial scale is limited and the…
Feasibility of Electrospraying Fully Aqueous Bovine Serum Albumin Solutions
Electrospraying or electrohydrodynamic atomisation, i.e. the formation of tiny droplets from a jet of conductive liquid under the influence of an electric field, has been gaining in popularity as a particle engineering technique in recent…
Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved…
Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low solubility and intestinal glucuronidation.
The nano-lipid carriers are characterized by small particle size,…
Vireo Health teams with Ligand on cannabis delivery methods
Article by Omar Sacirbay - mjbizmagazine
As an emergency room physician and the founding CEO of Vireo Health, a multistate marijuana company based in Minnesota, Kyle Kingsley had thought extensively about how cannabinoids could replace…
Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings
Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children.
The availability of pediatric formulations is particularly lacking in…
Formulation and evaluation of new oxycodone extended release multiple unit pellet system
The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads…
Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy
Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty years, remains the gold standard in the treatment of life-threatening invasive fungal infections and visceral leishmaniasis.
Due to its poor…
Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and…
Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold.
The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of…
Design space approach in the development of esculetin nanocrystals by a small-scale wet-bead milling…
Esculetin, a natural coumarin derived from herbs, has shown different potential pharmacological activities. However, the poor aqueous solubility of esculetin may limit its therapeutic efficacy. Nanocrystal is a promising dosage form to…
Effect of self-emulsifying phase composition on the characteristics of venlafaxine loaded alginate…
In this work, different formulations of alginate beads containing venlafaxine were prepared by ionotropic gelation. The drug was solubilized in a self-emulsifying phase composed of different percentages of Labrasol or Labrafil and…
Effects of Compaction Pressure, Speed and Punch Head Profile on the Ultrasonically-Extracted…
Despite a well-established manufacturing-process understanding, tablet quality issues are frequently encountered during various stages of drug-product development.
Compact breaking force (tensile strength), capping and friability are…
Sustained Release Ziprasidone Microparticles Prepared by Spray Drying with Soluplus® and Ethyl…
The purpose of this study was to develop and evaluate a new formulation of ziprasidone (ZIP) for improved fasted state absorption and sustained drug release.
ZIP solid dispersions were produced via spray drying using Soluplus®, an…
Production of Directly Compressible Excipients With Mannitol By Wet Granulation: Rheological,…
The purpose of this research was to produce co-processed excipients using mannitol as base material with some of the most used binders: potato, maize pre-gelatinized starch, and K-25, K-29/32, K-90 povidone.
Mannitol, one commercial…
Photopolymerized Micelle-Laden Hydrogels Can Simultaneously Form and Encapsulate Nanocrystals to…
Formulation technologies are critical for increasing the efficacy of drug products containing poorly soluble hydrophobic drugs, which compose roughly 70% of small molecules in commercial pipelines.
Nanomedicines, such as nanocrystal…
Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers
The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and…
Injectable in situ forming nanogel: A hybrid Alginate-NLC formulation extends bupivacaine anesthetic…
Finding an ideal anesthetic agent for postoperative pain control, with long action and low side effects, is still a challenge.
Local anesthetics have potential for such application if their time of action is improved. This work…
Formulation of self-microemulsifying drug delivery system (SMEDDS) by D-optimal mixture design to…
HL235 is a new cathepsin K inhibitor designed and synthesized to treat osteoporosis.
Since HL235 has poor aqueous solubility, a self-microemulsifying drug delivery system (SMEDDS) was formulated to enhance its oral bioavailability. A…
Spray Dried Formulations for Inhalation – Meaningful Characterisation of Powder Properties
Spray drying as a particle engineering technique is of increasing interest in the field of inhalation and is already being utilised e.g., for the PulmoSphereTM products.
As spray dried particles tend to agglomerate and are mechanically…
Novel Drug Approvals for 2019
Innovation drives progress. When it comes to innovation in the development of new drugs and therapeutic biological products, FDA’s Center for Drug Evaluation and Research (CDER) supports the pharmaceutical industry at every step of the…
Scale-up of electrospinning technology: Applications in the pharmaceutical industry
Electrospinning (ES) was originally reported in 1899 and the technology has been used since for the fabrication of con- tinuous fibers (Cooley, 1899).
Beginning from the 1980s and particularly during the recent decade, the technology has…
Montelukast Nanocrystals for Transdermal Delivery with Improved Chemical Stability
A novel nanocrystal system of montelukast (MTK) was designed to improve the transdermal delivery, while ensuring chemical stability of the labile compound.
MTK nanocrystal suspension was fabricated using acid-base neutralization and…
Ameliorated in vitro anticancer efficacy of methotrexate D-α-Tocopheryl polyethylene glycol 1000…
Background
Methotrexate (MTX), a folate anti-metabolite, has been used widely in the treatment of plenty of malignancies. However, the clinical use is limited because of its poor water solubility (BCS class II drug), nonspecific…
Design and Optimization of Nanostructured Lipid Carrier Containing Dexamethasone for Ophthalmic Use
The aim of this study was to perform a preformulation study of dexamethasone (DXM)-loaded nanostructured lipid carriers (NLCs) for ocular use. Lipid screening was applied to find the most suitable solid and liquid lipids and surfactant for…
Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible…
Powdered cellulose (PC) and microcrystalline cellulose (MCC) are common excipients in pharmaceuticals.
Recent investigations imply that particle size is the most critical parameter for the different performance in many processes.…
Insights on the Formulation of Recombinant Proteins
Recombinant proteins are large and complex molecules, whose therapeutic activity highly depends on their structure.
Formulation of biopharmaceuticals aims at stabilizing protein conformation, promoting its efficacy, and preventing safety…
Drug Delivery Technology Development in Canada
Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and…
Excipients to the year 2025 – and beyond
The developments in pharmaceutical excipient science and technology since 1995 have been reviewed.
The field of excipients science and technology has changed and continues to change. Some good progress has been made in such areas as…
Particle engineered mannitol for carrier-based inhalation – a serious alternative?
In dry powder inhalation (DPI), larger carrier particles, typically lactose, are blended with micronised active pharmaceutical ingredient (API) particles to improve handling, processability and inhalable fraction. Alternative carrier…