A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
Quality by Design in Pharmaceutical Manufacturing: a systematic review of current status, challenges…
Quality by Design (QbD) was originated in the broad domain of Quality Management and was recently adapted and formalized in specific terms for assisting pharmaceutical companies efforts towards market and operational excellence.
However,…
Trends in the production methods of orodispersible films
Interest in orodispersible films (ODF) is growing day-by-day, since this dosage form overcomes some therapeutic obstacles, such as impaired swallowing, and offers several benefits, such as the possibility to adapt the dosing requirements…
Fixed dose combinations for cardiovascular treatment via coaxial electrospraying: coated amorphous…
As a result of an aging population, the need for fixed dose combinations in the treatment of cardiovascular diseases, that are easy to swallow and administer, has been growing remarkably. In this work, the feasibility of coaxial…
Disruptive Materials – Pharma – presents a unique carrier for amorphous stabilization of poorly…
Located right in between Uppsala University, the Swedish Medical Products Agency and Uppsala University Hospital, the company is well positioned to exploit its pioneering discovery of a unique mesoporous magnesium carbonate (MMC) material.…
A review of the potential therapeutic and cosmetic use of propolis in topical formulations
A good deal of research has been carried out on the establishment and characterization of antioxidants and antibacterial products from natural sources for topical use. Recently, investors mainly from the cosmetics industry have become…
Numerical study for tableting process in consideration of compression speed
A numerical study of the tableting process using a finite element method (FEM) is important to quantitatively understand the structural change inside the tablet and the mechanism of tableting failures such as capping, picking, lamination,…
In vitro and in vivo cardioprotective and metabolic efficacy of vitamin E TPGS/Apelin
Aims
Apelin and vitamin E have been proposed as signaling molecules, but their synergistic role is unknown. The aim of this work was to develop vitamin E TPGS/Apelin system to test their cardioprotective and metabolic efficacy in…
Development Of Methamphetamine Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate
The objective of the present research was to investigate application of sucrose acetate isobutyrate (SAIB) in the development of a Meth-Deterrent formulation in combination with polyethylene oxide (PolyoxTM) and hydroxypropyl…
Nanostructured lipid carriers complexed with mesoporous silica nanoparticles in encapsulating…
Many functional substances are hardly dissolved in water or lipid at ambient temperature, which causes some difficulties in product formulation. Therefore, the aim of this research was to develop a novel carrier system by complexing…
Mapping key process parameters to the performance of a continuous dry powder blender in a continuous…
This work aims to expand the typical raw material attributes that can successfully be processed on a continuous direct compression line with a particular focus on the continuous dry powder blender. Three grades of Acetaminophen were…
Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery
Most cancer disease can be treated by the parenteral anticancer delivery method. The intravenous route takes the wholly bioavailable, accurate dose of the drug immediately to the body, but high plasma concentration has some side effects.…
Mechanistic understanding regarding the functionality of microcrystalline cellulose and powdered…
Powdered cellulose (PC) and microcrystalline cellulose (MCC) show considerable different behavior during wet-extrusion and spheronization.
While MCC is an appropriate pelletization aid, PC is not suitable. The differences were explained…
Cannabinoids in pharmaceutical development
The development of cannabinoids in the pharmaceutical industry has exploded over the past few years. With the gradual liberation of regulations worldwide that govern cannabis and its pharmaceutical derivatives for medicinal use, this week…
Improving the drug load and in vitro performance of supersaturated self-nanoemulsifying drug…
In this study, the influence of the polymeric precipitation inhibitor (PPI) PVP/VA 64 (polyvinylpyrrolidone-co-vinyl acetate) on the physical stability and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems…
Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity
Recently, cyclodextrin (CD) has shown the potential for effective treatment of atherosclerotic plaques in mice by solubilizing plaque cholesterol.
While promising as a new therapy for atherosclerosis, poor pharmacokinetics and…
Orodispersible Films Containing Ball Milled Aripiprazole-Poloxamer®407 Solid Dispersions
This research aimed at developing ODFs containing an antipsychotic drug – aripiprazole (ARP). ARP, as a BCS II class molecule, requires enhancing its water solubility prior to formulating.
Therefore, a solid dispersion of ARP –…
Kerry Launches Aero Flo Brand Inhalation Grades of Lactose at DDL 2019
Building on a long and well established history of supplying world class pharmaceutical grade lactose, film coatings, and tableting systems, Kerry introduces Aero Flo® Inhalation lactose, designed to meet the growing demand for lactose that…
New orodispersible mini-tablets for paediatric use – A comparison of isomalt with a mannitol based…
The development of orodispersible mini-tablets (ODMTs) for paediatric use has gained importance within recent years as European authorities set up regulations for developing suitable and palatable dosage forms for paediatric patients.…
Manufacturing strategies to develop amorphous solid dispersions: An overview
Since the past several decades, poor water solubility of existing and new drugs in the pipeline have remained a challenging issue for the pharmaceutical industry.
Literature describes several approaches to improve the overall solubility,…
EXCiPACT CELEBRATES ITS 100TH CERTIFICATION OF PHARMACEUTICAL EXCIPIENT SUPPLIERS
Brussels, 17 December 2019 - Press Release
EXCiPACT asbl is celebrating the award of the 100th GMP and/or GDP Certificate by one of its
internationally recognised Certification Bodies to either a manufacturer and/or a distributor of…
Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In…
Hypertension shows circadian blood pressure rhythms (day–night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels.
Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that…
The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via…
Huperzine A (HupA) is a selective acetylcholinesterase inhibitor used to treat Alzheimer’s disease. The existing dosage of HupA lacks brain selectivity and can cause serious side effects in the gastrointestinal and peripheral cholinergic…
Taste masking of propranolol hydrochloride by microbeads of EUDRAGIT® EPO obtained with prilling…
The purpose of this study was to develop a new solid paediatric formulation for propranolol hydrochloride (PR).
This drug is used to treat various paediatric diseases, and recently received clearance to treat haemangioma. However, PR has…
Potential Active Targeting of Gatifloxacin to Macrophages by Means of Surface-Modified PLGA…
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and represents one of the leading causes of mortality worldwide due to multidrug-resistant TB (MDR-TB). In our work, a new formulation of biodegradable PLGA…
Insight into Concept and Progress on Pharmaceutical Co-Crystals: An Overview
Pharmaceutical co-crystals have conferred significant recognition in recent past as a new solid form by virtue their capability to modulate physicochemical properties of Active Pharmaceutical Ingredient (API).
Nevertheless,…
List of Off-Patent, Off-Exclusivity Drugs without an Approved Generic
The FDA maintains a list of approved new drug application (NDA) drug products that are no longer protected by patents or exclusivities, and for which the FDA has not approved an abbreviated new drug application (ANDA) referencing that NDA…
Design, optimisation and evaluation of in situ gelling nanoemulsion formulations of brinzolamide
The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma.
Nanoemulsions were prepared…
Carvedilol solid dispersion for enhanced oral bioavailability using rat model
The objective of the present study was to develop a solid dispersion formulation to improve oral bioavailability of poorly water-soluble drug carvedilol. Several solid dispersions were prepared by fusion-solvent method mixing different…
3D-Printed Solid Dispersion Drug Products
With the well-known advantages of additive manufacturing methods such as three-dimensional (3D) printing in drug delivery, it is disappointing that only one product has been successful in achieving regulatory approval in the past few years.…
The effect of alcohol on ionizing and non-ionizing drug release from hydrophilic, lipophilic and…
The aim of this work was to investigate and quantitatively evaluate the effect of presence of alcohol on in vitro release of ionizing and non-ionizing drug from hydrophilic, lipophilic and hydrophilic-lipophilic matrix tablets. The Food and…
Impact of Die Wall Material on the Mechanical Properties of Paracetamol Tablets
Tablet quality can be affected by material, configuration and design of the tooling which comprise punches and dies. Much research attention had centred around punches, with very little reported on the dies.
Dies with modified bore…
Novel Surfactant Excipient Significantly Improves Biologic Stability in Liquid Formulation
As you maybe aware, polysorbates present a host of challenges for stabilizing biopharmaceuticals due to their own stability issues. To adress this, DuPont Pharma Solutions developed a new surfactant, an experimental material called FM1000!…
A review on novel methodologies for drug nanoparticle preparation: Microfluidic approach
The intrinsic limitations of conventional dosages have facilitated the emergence of novel drug delivery methodologies. Drug nanonization and encapsulation in polymeric biomaterials offers a new platform to enhance therapeutic efficiency and…
Top 10 Pharma Trends 2020
What key trends or issues emerged in 2019 that are positioned to be on the industry’s radar in 2020? DCAT Value Chain Insights provides a Top 10 ranking. Article by By Patricia Van Arnum - DCAT Editorial Director
1. Drug-pricing reform…