A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
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9th – 11th March 2020 | Berlin
The perfect mix. The DDF Summit brings together leading formulation development, drug delivery and device development…
Evaluation of Lipophilic Properties of Thermoplastic Granule in Formulation of Sustained Release…
This study was aimed at developing a new, technically simple method for the preparation of a once-daily sustained release matrix formulations, which would enable reproducible release of the active ingredient.
Thermoplastic granulation is…
Decoding the Small Size Challenges of Mini-tablets for Enhanced Dose Flexibility and Micro-dosing
Mini-tablets are an age appropriate dosage form for oral administration to pediatric and geriatric patients, either as individual mini-tablets or as composite dosage units.
Smaller mini-tablets than the commonly used 2 mm or larger size…
Lipid Nanoparticles by Gattefossé
Lipid-based nanocarriers are promising tools to deliver APIs, including peptides, as their nanosize are in favour of transepithelial transport.
Solid Lipid Nanoparticles (SLN) are composed of lipids in solid state at room and body…
Retinoic acid-loaded NFL-lipid nanocapsules promote oligodendrogenesis in focal white matter lesion
Neural stem cells (NSC) are located in restricted areas of the central nervous system where they self-renew or differentiate into neurons, astrocytes or oligodendrocytes.
The stimulation of endogenous NSC differentiation is one of the…
Self-Micellizing Technology Improves the Properties of Ezetimibe and Increases Its Effect on…
The aim of this work was to develop ezetimibe self-micellizing solid dispersions using Kolliphor® RH40 (MS-K) as a surfactant incorporating ezetimibe (EZ) into the croscarmellose hydrophilic carrier.
Different ezetimibe:Kolliphor® ratios…
Successful development of oral SEDDS: screening of excipients from the industrial point of view
Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of infections can be avoided resulting in a comparatively high patient compliance.
However, from the industrial point of view…
Mechanistic Evaluation of Enhanced Curcumin Delivery through Human Skin In Vitro from Optimised…
Curcumin is a natural product with chemopreventive and other properties that are potentially useful in treating skin diseases, including psoriasis and melanoma.
However, because of the excellent barrier function of the stratum corneum…
Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies
Viral infections affect three to five million patients annually.
While commonly used antivirals often show limited efficacy and serious adverse effects, herbal extracts have been in use for medicinal purposes since ancient times and are…
Improving solubility – a close look at available approaches
The need to improve the solubility of active pharmaceutical ingredients (APIs) has been rising for decades. Today, this need is increasingly pressing, as the number of APIs that are poorly water-soluble (based on their BCS classification)…
Impact of Processing Parameters on the Quality of Pharmaceutical Solid Dosage Forms Produced by…
Fused deposition modeling (FDM) three-dimensional (3D) printing is being increasingly explored as a direct manufacturing method to product pharmaceutical solid dosage forms.
Despite its many advantages as a pharmaceutical formulation…
Robustness of a continuous direct compression line against disturbances in feeding
The aim of the current study was to characterize the robustness of an integrated continuous direct compression (CDC) line against disturbances from feeding, i.e. impulses of API and short step disturbances. These disturbances mimicked…
Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics
Embedded three-dimensional printing is an emerging method for additive manufacturing where semi-solid materials are extruded within a solidifying liquid matrix.
Here, we present the first example of employing Embedded three-dimensional…
Improved solubility, dissolution, and oral bioavailability for atorvastatin- Pluronic® solid…
Despite the status of atorvastatin (AT) as one of the top selling statins for prophylaxis against primary and secondary cardiovascular diseases, its limited oral absorption limits its full therapeutic benefits.
Herein, formulations of AT…
Self-Emulsifying Drug Delivery Systems: Easy to Prepare Multifunctional Vectors for Efficient Oral…
Self-emulsifying drug delivery systems (SEDDS) have been mainly investigated to enhance the oral bioavailability of drugs belonging to class II of the Biopharmaceutics Classification System. However, in the past few years, they have shown…
Size reduction in feed technology and methods for determining, expressing and predicting particle…
Particle size of diets or ingredients plays an important role in pig growth and gut health.
The way the size of particles is measured and expressed, however, is limited in explaining pig growth performance differences. This review…
Effects of process parameters of rotary tablet press on die filling behavior during mini-tablet…
This study focuses on the effects of process parameters of rotary tablet press on die filling behavior during the mini-tablet production.
Fill cam type, adjusted fill depth, and disc rotational speed were modulated, and mean tablet weight,…
The Pharmaceutical Industry Year 2019 in Review
As 2019 comes to a close, what was the top news stories shaping the pharmaceutical industry? From mega acquisitions to deal-making in cell and gene therapies, to shifting supply lines from a still-to-be resolved Brexit and ongoing trade…
Development of dual–release pellets of the non-steroidal anti–inflammatory drug celecoxib
In the current study, once-a-day dual-release pellets of the selective non-steroidal anti-inflammatory drug celecoxib (200 mg) was developed to treat arthritis.
Pellets were prepared where a 100 mg celecoxib, located in the outer layer,…
A Mechanistic Understanding of Compression Damage to the Dissolubility of Coated Pellets in Tablets
Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system tablets is a major concern.
Previous studies have shown that pellets located at the tablet axial…
Speed it up, slow it down…An issue of bicalutamide release from 3D printed tablets
The article describes the preparation and characterization of 3D-printed tablets with bicalutamide obtained using two-material co-extrusion-based fused deposition modeling (FDM).
This method is a modification of typical two-material FDM…
Engineering drug delivery systems to overcome mucosal barriers for immunotherapy and vaccination
Mucosal surfaces protect our bodies from pathogens and external irritants using a system of biological barriers.
Overcoming these barriers is a significant drug delivery challenge, particularly for immunotherapies that aim to modulate…
Relationship between compression pressure, mechanical strenghth and release properties of tablets
Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipi- ents.
Tablet production involves a series of unit operations in which drugs and excipients are subjected to mechanical stresses,…
Advanced Tablet Coating Development: Applying Optical Coherence Tomography (OCT) as a PAT Tool for…
Purpose: Novel tablet coating approaches include the development of continuous coating technologies. This requires a high level of automation to assure the quality and safety of the final coated product. Despite automation of control…
Effect of Stabilizers on Encapsulation Efficiency and Release Behavior of Exenatide-Loaded PLGA…
The aim of this study was to investigate the effects of various stabilizers on the encapsulation efficiency and release of exenatide-loaded PLGA (poly(lactic-co-glycolic acid)) microspheres prepared by the water-in-oil-in-water (W/O/W)…
Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally…
This study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets.
With an increase in immersion…
Cyclodextrins: Emerging Medicines of the New Millennium
Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as excipients. Nevertheless, developments in cyclodextrin research have shown that some of these hosts can capture and include biomolecules, highlighting…
Polyvinyl Alcohol (PVA) for Tablet Coating Applications: Enhancing Formulation Flexibility
Purpose: Polyvinyl alcohol (PVA) is a well-established polymer for film coating. PVA is a synthetic, bio-compatible and toxicologically well characterized polymer. It is frequently used in pre-mixed coating formulations. Fixed combinations…
In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems
Introduction: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing to its accessibility, safety and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by in…
Optimization and characterization of novel sustained release supermicro-pellet based dry suspensions…
Traditional dosage forms of dexibuprofen extremely limit their clinical applications because of the bitter taste and the frequent drug administration caused by the relatively short half-life of the drug.
This study aims to design novel…
Design and Development of Liquid Drug Reservoirs for Microneedle Delivery of Poorly Soluble Drug…
The poor aqueous solubility of existing and emerging drugs is a major issue faced by the pharmaceutical industry.
Water-miscible organic solvents, termed co-solvents, can be used to enhance the solubility of poorly soluble substances.…
Dry particle high coating of biopowders: An energy approach
The general aim of this paper is to study the coating strength of different composite powders with an experimental approach based on mixing energy descriptors derived from linear velocity at the end of paddles. The chosen system is Cellets…
Recent advances in the delivery of disulfiram: a critical analysis of promising approaches to…
Background
Disulfiram (DSF) has a long history of being used as a first-line promising therapy for treatment of alcoholism in human. Besides its prominence in the treatment of alcoholism, extensive investigations have been carried out to…
Unique coated neusilin pellets with a more distinct and fast visual detection of nerve agents and…
Pellets with an immobilized enzyme (acetyl- or butyrylcholinesterase) are the up-to-date type of carriers used for the detection of nerve agents (soman, sarin, tabun, VX, Novichok) and other cholinesterase inhibitors such as organophosphate…