Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Formulation design and characterization of self nano emulsifying drug delivery system (SNEDDS)…
Background
Roxithromycin is a macrolide antibiotic included in the biopharmaceutics classification system (BCS) class II with poor water solubility (0.0189 mg/mL) resulting poor solubility of roxithromycin in gastrointestinal track and…
Development of a Novel Pharmaceutical Formula of Nanoparticle Lipid Carriers of Gentamicin/α-…
Gentamicin is a potent antibiotic with a nephrotoxicity drawback which limits its use. D-α-tocopherol polyethylene glycol succinate (α-tocopherol) is widely used as a surfactant and have potent antioxidant properties. This study aimed to…
DuPont Smart Pharma Solutions: Essential Excipients and Vital Expertise
DuPont aims to help their pharma customers overcome everyday challenges and innovate future solutions. Armed with essential excipients and vital expertise, the broad portfolio is designed to deliver performance and cost advantages in…
Nanohydrogels Based on Self-Assembly of Cationic Pullulan and Anionic Dextran Derivatives for…
A cationic derivative of pullulan was obtained by grafting reaction and used together with dextran sulfate to form polysaccharide-based nanohydrogel cross-linked via electrostatic interactions between polyions.
Due to the…
Solvent-free Hot Melt Extrusion Technique in Improving Mesalamine Release for Better Management of…
Poor oral bioavailability of mesalamine (Mes) is due to extensive metabolism in the intestinal epithelial cells in addition to the liver.
Purpose: Improved mesalamine release by Hot-Melt Extrusion (HME) technique could be utilized for…
CPhI India 2019 – Impressions from the Excipients Manufacturers
Today is the last day of CPhI India. Maybe you had not the chance to visit the fair and are interested to get some impressions. We did a small photo gallery of the exhibition booths of some excipients suppliers. Just click to see all the…
Determinants of zero-order release kinetics from acetaminophen-layered Suglet® pellets,…
The potential for zero-order drug-release was evaluated for ethyl cellulose (EC) coated, acetaminophen-layered sugar pellets (Suglets®) of mesh size 18/20 (850–1000 μm).
To determine optimal plasticizer/pore-former concentrations for EC…
Ground Calcium Carbonate as a Low Cost and Biosafety Excipient for Solubility and Dissolution…
Calcium carbonate is an abundant mineral with several advantages to be a successful carrier to improve oral bioavailability of poorly water-soluble drugs, such as praziquantel.
Praziquantel is an antiparasitic drug classified in group II…
Development and Characterization of a Semi-Solid Dosage Form of Meglumine Antimoniate for Topical…
Cutaneous leishmaniasis (CL) is treated with painful intralesional injections of meglumine antimoniate (MA).
With the aim of developing an alternative topical treatment for CL, a gel-based formulation with 30% MA was prepared and its…
Elucidating molecular design principles for charge-alternating peptides
The therapeutic potential of protein drugs has been hindered by difficulties with long-term stability and rapid clearance from the body.
Recombinant fusion proteins provide a scalable platform for engineered biologics, whereby a…
Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects…
Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately 20-25% of patients.
Thus,…
PMC Isochem invests 2 Millions € in R&D
2019 Nov 22
PMC Isochem invests 2 Millions € in new R&D capability: New labs, Kilolab and new analytical technology equipment.
This R&D capability expansion will support CDMO and Polyamino acids for Drug delivery…
Fabrication of floating capsule-in- 3D-printed devices as gastro-retentive delivery systems of…
Gastro-retentive drug delivery systems (GRDDS) provide prolonged drug release in the stomach for the treatment of some diseases located in the gastric area, and can improve patient compliance by reducing the required dosing frequency.
In…
Species differences in ocular pharmacokinetics and pharmacological activities of regorafenib and…
Age-related macular degeneration (AMD) is the leading cause of severe vision impairment in patients over the age of 60 years.
Choroidal neovascularization (CNV) is the hallmark of neovascular AMD and vascular endothelial growth factor…
Determination of Stable Co-Amorphous Drug–Drug Ratios from the Eutectic Behavior of Crystalline…
Co-amorphous drug–drug systems have been developed with the overall aim of improving the physical stability of two or more amorphous drugs.
Co-amorphous systems often show good physical stability, and higher solubility and dissolution…
Study of Drug Particle Distributions within Mini-tablets Using Synchrotron X-ray Microtomography and…
Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients.
In this work, the drug particle distribution in…
Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for…
Microcrystalline cellulose production from sugarcane bagasse: Sustainable process development
Sugarcane bagasse (SCB), a major and abundantly available byproduct of sugarcane processing industries is presently being used for energy generation.
However, its rich resource content makes it a perfect feedstock for production of…
Formulating pediatric taste masked multiparticulates using CPS Technology – AAPS Poster
Developing formulations appropriate for children still remains to be a major formulation challenge for the pharmaceutical scientists as children are different than adults in many aspects of pharmacotherapy, including capabilities for drug…
Nano-crystalline cellulose: Preparation, modification and usage as sustained release drug delivery…
Nano crystalline cellulose (NCC) has gained attention in the pharmaceutical industry owing to its biodegradable nature and high mechanical properties.
In the present work we reported preparation of NCC from cellulose isolated from a…
Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody…
Short freeze-drying cycles for biopharmaceuticals are desirable. Formulations containing an amorphous disaccharide, such as sucrose, are prone to collapse upon aggressive primary drying at higher shelf temperature.
We used…
A proof-of-concept for developing oral lipidized peptide Nanostructured Lipid Carrier formulations
The aim of the study was to develop a protocol to encapsulate lipidized-peptides in Nanostructured Lipid Carrier (NLC) by High Pressure Homogenization (HPH) for oral delivery.
The impact of composition, pressure and number of cycles on…
Controlled Delivery of Dutasteride Using Dissolvable Microarrays: Initial Formulation and In-vivo…
Dutasteride is prescribed as a once daily oral capsule for the treatment of symptomatic benign prostatic hyperplasia.
As an alternative and patient focused drug product, this laboratory evaluated the potential to deliver dutasteride in a…
Neem gum based pH responsive hydrogel matrix: A new pharmaceutical excipient for the sustained…
The present research work was aimed to synthesize neem gum-based site-specific drug delivery device for anticancer drug methotrexate at different pH condition.
The hydrogel-based drug delivery device was synthesized by optimizing…
Insights of Taste Masking from Molecular Interactions and Microstructures of Microspheres
The effects of taste masking are determined by interactions between drug and excipients as well as the microstructures of the particulate drug delivery systems (DDS).
Cyclodextrin (CD) is a widely used taste masking agent, to which the…
Mechanistic Modelling of Fluid Bed Granulation, Part II: Eased process development via Degree of…
The performance of a fluid bed granulator was investigated through experimental and numerical study to develop a stand-alone fluid bed granulation model.
The single-compartment model proposed in part I (for agglomeration modeling) was…
Comparison of different drag models in CFD-DEM simulations of spouted beds
Spouted beds are commonly simulated through the Computational Fluid Dynamics – Discrete Element Method approach.
The choice of the drag model is still a matter of debate, as they feature peculiar operative conditions. In this work, we…
Mechanistic Modelling of Fluid Bed Granulation, Part I: Agglomeration in Pilot Scale Process
The present study aims to develop a mechanistic model to predict the performance of a fluid bed granulation process.
Therefore, the behavior of the bed was investigated experimentally for various operating conditions. It was observed…
Is rat a good model for assessment of particulate-based taste-masked formulations?
Recently there has been an increased interest to develop specialised dosage forms that are better suited to specific patient populations, such as paediatrics and geriatrics.
In these patient populations the acceptability of the oral…
How to Minimize Weighing Errors Using Lean Laboratory Principles
The application of Lean Laboratory principles is becoming increasingly popular in the calibration and quality assurance labs for minimizing errors. The reason being, Lean Laboratory techniques focus on accurately measuring products or…
Amorphous Solid Dispersion Formation via Solvent Granulation – A Case Study with Ritonavir and…
With an increase in the number of therapeutically active compounds exhibiting low water solubility, formulation strategies such as amorphization, salt formation, complexation, micellization, are increasingly employed to improve solubility…
Approaches to supply bioequivalent oral solid pharmaceutical formulations through the lifecycles of…
The continuous supply of pharmaceutical formulations therapeutically equivalent to the clinical batches used during development is important to ensure their safety and efficacy.
The development of new generic drugs and the postapproval…
Formulation of Direct Compression Zidovudine Tablets to Correlate the SeDeM Diagram Expert System…
The SeDeM diagram expert system has been applied to study Zidovudine and some excipients. From the obtained diagrams, a pharmaceutical formula has been designed. SeDeM diagram ascertains the critical parameters that are suitable for a…
Development of Proliposomal and Liposomal Formulations with Poorly Water-soluble Drugs
The aim of this work was to develop proliposomal formulations and corresponding liposomes. The focus was on a formulation suitable for large-scale production of PLs using the coating method. In addition, the spray drying process was…