Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Availability of age-appropriate paediatric formulations in the Netherlands: the need in daily…
Drug development for children has long been a neglected area compared with adult drug development. Low prevalence of disease and the resulting low return on investment, together with ethical and practical barriers, have not been providing…
Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral…
Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at…
Continuous manufacturing process monitoring of pharmaceutical solid dosage form: A case study
Continuous Manufacturing (CM) of pharmaceutical drug products is a rather new approach within the pharmaceutical industry. In the presented paper, a GMP continuous wet granulation line used for clinical production of solid dosage forms was…
Scalable electrospinning and -spraying solutions by Bioinicia
Your partner for advanced materials solutions for the pharma industry!
With more than a 100 years of cumulated experience, Bioinicia is the first company to have overcome the upscaling issues related to the electrospinning and…
Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold
From a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety.
The aim of the presented work was to prepare a buccal film…
At-line Validation of Optical Coherence Tomography as In-line/At-line Coating Thickness Measurement…
Optical Coherence Tomography (OCT) is a promising technology for monitoring of pharmaceutical coating processes.
However, the pharmaceutical development and manufacturing require a periodic validation of the sensor’s accuracy. For this…
Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose
Achieving drug delivery at the ocular level encounters many challenges and obstacles.
In situ gelling delivery systems are now widely used for topical ocular administration and recognized as a promising strategy to improve the treatment…
Improved oral bioavailability of anticancer drug tamoxifen through complexation with water soluble…
Tamoxifen (TMX), a class II antiestrogen drug consistent with the biopharmaceutical classification system, shows low plasma levels leading to therapeutic failure as a result of poor aqueous solubility.
Complexation with multifunctional…
Polymeric Nanomicelles of Soluplus® as a Strategy for Enhancing the Solubility, Bioavailability and…
Soluplus® is a commercially available graft amphipathic copolymer consisting of polyvinyl caprolactam, polyvinyl acetate, and polyethyleneglycol (13% PEG 6000/57% vinyl caprolactam/30% vinyl acetate).
Among the various applications of…
Ligand Presents Positive Results from Phase 1 Clinical Trial of Captisol-enabled Iohexol
Ligand Pharmaceuticals Incorporated presented positive results from a Phase 1 clinical trial of its Captisol-enabled (CE) Iohexol program at ASN Kidney Week 2019 in Washington, D.C.
The CE-Iohexol program was established in January 2018…
Incorporation of HPMCAS during loading of glibenclamide onto mesoporous silica improves dissolution…
Mesoporous silica has emerged as an enabling formulation for poorly soluble active pharmaceutical ingredients (APIs).
Unlike other formulations, mesoporous silica typically does not inhibit precipitation of supersaturated API therefore,…
Amino acids as stabilizers for spray-dried simvastatin powder for inhalation
Background
The use of amino acids as excipients is a promising approach to improve the physical stability and powder dispersibility of spray-dried powders for inhalation.
Objectives
The aim of this study was to investigate the…
Orodispersible Mini-tablets based on galenIQ™ 721
Orodispersible mini-tablets (ODMTs) are becoming increasingly more important to pharmaceutical companies, as the clinical benefit for peadiatric patients has been proven. In literature mini-tablets are described as solid dosage forms with a…
A wet-milling method for the preparation of cilnidipine nanosuspension with enhanced dissolution and…
Cilnidipine (CLD) is extensively used in the treatment of hypertension; however, it has extremely low solubility which limits its clinical application.
The purpose of the present research was to improve the dissolution rate and oral…
Preparation and dissolution characteristic evaluation of carvedilol-Kollicoat IR solid dispersions…
In this study, the abilities of hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) as nonionic surfactants to improve the dissolution rate of carvedilol solid dispersions (CAR SDs) with Kollicoat IR as a carrier were clearly…
Inclusion complexes of atorvastatin calcium–sulfobutyl ether β cyclodextrin with enhanced…
The aim of present study was to explore the impact of Atorvastatin (ATR) Sulfobutylether beta-cyclodextrin complex (ATR-SBE-β-CD) on ATR dissolution behavior.
Various batches of inclusion complexes were formulated using various drug:…
Investigation of the effect of compaction speed on the compressional behavior of microcrystalline…
The main goal of this thesis was to examine the effect of the compaction speed on the compressional behavior of two excipients, microcrystalline cellulose and starch, using an eccentric and rotary presses.
First, the average weights of…
A study of anionic, cationic, and nonionic surfactants modified starch nanoparticles for hydrophobic…
Starch nanoparticles were prepared from native potato starch using acid hydrolysis and precipitation methods.
The acid hydrolysis method yielded high relative crystallinity of starch nanoparticles (SNP-H), while ethanol precipitation…
The Effect of Freeze-Drying on Mucoadhesion and Transport of Acrylated Chitosan Nanoparticles
Nanoparticle-based mucosal drug delivery is a promising method to increase the residence time of a drug in the mucosa.
It is known that the stability of polysaccharide-based nanoparticles in aqueous solutions is limited, due to…
Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based…
Pharmaceutical applications of three dimensional (3D) printing technology are increasing following the approval of 3D-printed tablets by the U.S. Food and Drug Administration.
Semi-solid extrusion-type 3D printers are used to 3D print…
An Update of Moisture Barrier Coating for Drug Delivery
Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages.
Moisture barrier film coating is one of the most appropriate and effective approaches…
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent.
Currently, polymer-based amorphous formulations manufactured by spray…
Comparison of Proprietary and 3 Generic Formulation of Propofol for Induction of General Anesthesia
Background: This study compared the properties of propofol bolus for induction of general anesthesia between proprietary and 3 generic formulations, to assess if solvent differences had clinically relevant consequences on efficacy or side…
Feel the pulse of CPhI on the last day
A few hours ago, CPhI worldwide in Frankfurt closed their doors for this year. We want to show you the general look and feel with a few walkthroughs and photos.Walkthrough Hall 11.0 P-MEC & InnoPack:
Walkthrough Hall 11.1…
Interview with Biogrund Founder at CPhI 2019
Biogrund is servicing the pharmaceutical industry for 20 years now with ready-made and tailored film coatings and binders. Hear Hans Respondek, the company founder explaining the companies' service understanding and philosophy as well as…
New Impressions from CPhI Worldwide in Frankfurt 2019
Welcome back to the second day of CPhI!
Today we want to show you a few walkthroughs and some interesting looking fair stands:
Poster presentation Gattefossé
See the presentation of Sophie Hughes from Gattefossé at CPhI Worldwide where she talked through a poster presentation on the formulating of cannabinoids with lipid excipients. To find out more about this and Gattefossé´s whole portfolio of…
Combining excellent taste and functionality – galenIQ™
BENEO’s sweet pharmaceutical excipient — galenIQ™ — improves both minitablet production and patient compliance
Tablets are still the most widely used drug delivery system. However, some patient groups, including the elderly, people with…
Evolutions of temperature and density during roll compaction of a pharmaceutical excipient
Roll compaction is a critical unit operation in the pharmaceutical manufacture. During roll compaction, a change in the internal energy of powder due to applying of external work from the rolls can generate heat and cause an increase in the…
galenIQ™ for minitablets – Visit BENEO at CPhI Worldwide 2019
Dr. Maj-Britt Cepok from BENEO gives a brief overview of the possibilities of galenIQ™ for minitablets at CPhI Worldwide in Frankfurt . To find out more about this sweet filler binder, visit their stand in Hall 10.2 stand C11 and see our…
First day walkthrough excipients hall at CPhI
CPhI worldwide in Frankfurt started today.
Talk a quick walk through the excpients hall with us !
See our video about the excipient hall at CPhI:
or the custom manufacturing hall:
Here you see…
BENEO’s sweet pharmaceutical excipient enables formulations of the future
Combining great taste and excellent functionality, galenIQ™ is setting new standards in minitablet production
Mannheim (Germany), November 2019 – CPhI Worldwide, 5–7 November in Frankfurt a.M., is the perfect place to make new…
Application of Externally Applied Lower Punch Vibration and its Effects on Tablet Manufacturing
In the present study the influence and application of a newly developed external lower punch vibration system for an improved die filling on a running rotary tablet press was investigated.
Methods
Tablets were manufactured at…