A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
First day walkthrough excipients hall at CPhI
CPhI worldwide in Frankfurt started today.
Talk a quick walk through the excpients hall with us !
See our video about the excipient hall at CPhI:
or the custom manufacturing hall:
Here you see…
BENEO’s sweet pharmaceutical excipient enables formulations of the future
Combining great taste and excellent functionality, galenIQ™ is setting new standards in minitablet production
Mannheim (Germany), November 2019 – CPhI Worldwide, 5–7 November in Frankfurt a.M., is the perfect place to make new…
Application of Externally Applied Lower Punch Vibration and its Effects on Tablet Manufacturing
In the present study the influence and application of a newly developed external lower punch vibration system for an improved die filling on a running rotary tablet press was investigated.
Methods
Tablets were manufactured at…
The best-selling drugs of the next 5 years
Merck & Co’s immuno-oncology drug Keytruda (pembrolizumab) is projected to be the best-selling drug by annual revenue in 2023, earning $22.2 billion by 2025, according to new research by GlobalData.
Article by pharmaphorum.com
The…
Chemically Modified Starches as Excipients in Pharmaceutical Dosage Forms
Excipients play a great role in ensuring that pharmaceutical dosage form meets the required specifications of quality approved by the relevant authorities.
Starches are the most widely used excipients in dosage form development, but…
Spray-drying of inhalable, multifunctional formulations for the treatment of biofilms formed in…
Cystic fibrosis (CF) is a serious lung disease, commonly susceptible to Pseudomonas aeruginosa colonization.
The dense mucus together with biofilm formation limit drug permeability and prevent the drug from reaching the site of action,…
Novel multi-channel orally disintegrating tablets
In this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through…
Microencapsulation to enhance the storage stability of Lactobacillus rhamnosus GG
Probiotics are the microorganism which when administered in sufficient amount confers health benefits.
The major challenge encountered is the viability during administration and storage stability. In order to overcome these limitation…
Gattefossé TechChats @CPhI Booth #10.2B80
Gattefossé Techchats Program
Easy taste-masking for pediatric medicines development.
New Suppocire® grades for flexibility and high performance.
How to simplify topical formulations and get great stability and texture.…
Polyvinyl alcohol boric acid – A promising tool for the development of sustained release drug…
The paper deals with the design and investigation of the morphology, in vitro drug release and biocompatibility of some new formulations based on polyvinyl alcohol boric acid (PVAB) and diclofenac sodium salt (DCF), with the aim to explore…
Effect of particle size distribution on flowability of granulated lactose
The flowability of powders used in tableting significantly affects tablet weight and content uniformity of active pharmaceutical ingredients. Use of granulated materials instead of powdered materials can improve flowability. In this study,…
Drug shortages mainly due to Quality issues – says Janet Woodcock
"To Help Reduce Drug Shortages, We Need Manufacturers to Sell Quality — Not Just Medicine"
By: Janet Woodcock, M.D., Director, Center for Drug Evaluation and Research
You might not always shop based solely on the lowest price.…
CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3…
Prexasertib (LY2606368) is a potent and selective small molecule inhibitor of cell-cycle checkpoint CHK1 and CHK2 protein kinases and is currently under clinical evaluation for treatment of pediatric malignancies.
As a candidate therapy…
On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified?
Oral direct compressible tablets are the most frequently used drug products. Manufacturing of tablets requires design and development of formulations, which need a number of excipients. The choice of excipients depends on the concentration,…
galenIQ™ as Excipient for Orodispersible Minitablets
Tablets are the most widely-used drug delivery system.However, some patient groups including young children, the elderly and patients with dysphagia can have difficulty in swallowing conventional tablets. Especially due to their size and…
Liquid filling of hard gelatine capsules
Liquid filling of hard gelatine capsules is an interesting approach to handle oily substances such as plant extracts incl. CBD in a better way.
IN-CAP has become very popular all over the World among R&D Laboratories, Pharmacies,…
Development of conjugate-by-conjugate structured nanoparticles for oral delivery of docetaxel
In the current study, we developed interpolymer-complex structures composed of hydroxypropyl methylcellulose (HPMC) and chitosan knitted with d-α-tocopherol polyethylene glycol succinate (TPGS) to establish oral nanoparticle delivery…
SEPIFILM White TF: White coating agent without TiO2 for tablet coating
SEPIFILM™ White TF is a white, ready-to-use film-coating agent without titanium dioxide. It is a new solution with strong opacifying properties, allowing the obtention of white coated tablets without titanium dioxide.
It has been…
Poly (Lactic Acid) Nano-fibers as Drug-delivery Systems
Numerous Scientists have discovered the procedure of nano-technology, explicitly nano-fibers, as drug-delivery systems for trans-dermal uses.
Nano-fibers can be used to deliver drugs and are capable of controlled-release for a continued…
Excipient Manufacturers at CPhI Frankfurt
We gladly invite you to visit our partners at CPhI Worldwide in Frankfurt. You will find them here:
ARMOR PHARMA manufactures and markets 3 ranges of pharmaceutical grade lactose for all your applications.
Booth - 102B101
BASF…
Understanding drug distribution and release in ophthalmic emulsions through quantitative evaluation…
Establishing bioequivalence (BE) of ophthalmic emulsions in the absence of in vivo data is challenging.
In these emulsions, drug release is a complex process due to drug distribution among various phases which are difficult to…
Happy Diwali from pharmaexcipients
May you life be as colourful, shimmering and magical as the lights of Diwali!
Modeling of inter- and intra-particle coating uniformity in a Wurster fluidized bed by a coupled…
A coupled CFD-DEM and Monte Carlo approach was developed to investigate coating properties in a Wurster fluidized bed by considering gas flow, particle motion, droplet deposition, and the drying and solidifying of droplets on particle…
Particle-level residence time data in a twin-screw feeder
A full discharge process of a twin-screw feeder has been simulated with DEM (discrete element method).
The result files are available at the Mendeley Data repository (https://doi.org/10.17632/d76rzzd8r7.1) and contain the following…
Polymeric microneedles for controlled transdermal drug delivery
Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems because of their controlled drug delivery, tunable properties, and ease of patient self-administration.
They are biocompatible and can easily and…
Prilling of API/fatty acid suspensions: processability and characterisation
Current study evaluated the processability and characteristics of prills made of an active pharmaceutical ingredient/fatty acid (API/FA) suspension instead of previously studied API/FA solutions to enlarge the application field of prilling.…
A compression behavior classification system of pharmaceutical powders for accelerating direct…
In this paper, a compression behavior classification system (CBCS) for direct compression (DC) pharmaceutical powders is presented. Seven descriptors from a series of compression models for powder compressibility, compactibility and…
Adjusting the Release Rate of Mesalazine from Matrix Formulations by Addition of various Excipients
Mesalazine is widely used drug compound to treat inflammations within the gastrointestinal tract (GIT). The APIs is mostly supplied as very fine powder with extremely poor flowability and wet granulation is most often used to meet the…
Maisine® CC, the pharmaceutical oil from Gattefossé
A short introduction to Maisine® CC, the new pharmaceutical oil from Gattefossé, a solubility and oral bioavailability enhancer!
Maisine® CC is Gattefossé's tradename for Glycerol/Glyceryl monolinoleate (EP, USP-NF), also known as corn…
Study of the critical points in combined matrix tablets containing both inert and swelling…
This work estimates for the first time critical points in combined matrices containing varying concentrations of the hydrophilic polymer Hydroxypropyl methylcellulose (HPMC) K100 M CR in presence of a constant percentage of the inert matrix…
A self-emulsifying Omega-3 ethyl ester formulation (AquaCelle) significantly improves…
Purpose
Application of intelligent formulation design has the ability to address the poor bioavailability and improve the fasted state bioavailability of fish oils. In this study we assessed the ability of a self-emulsifying drug…
Novel Ultrasonic In-die Measurements during Powder Compression at Production Relevant Speed
A novel ultrasonic instrumentation was successfully implemented in a compaction simulator. A through-transmission set-up was realised with longitudinal and transverse transducers being alternately positioned inside Euro-D-modified punches.…
Optimization and tracking of coating processes of pellets with polyvinylpyrrolidone solutions in an…
The purpose is to present the application of the acoustic levitation as a model system for a coating process with non-spherical and light particles in the fluidized bed reactor.
An acoustic levitator has been used to track a pellet in a…
Continuous drying of a protein-type drug using scaled-up fiber formation with HP-β-CD matrix…
The goals of this work were to evaluate if high-speed electrospinning can be used as a gentle and continuous drying technology to produce protein-containing cyclodextrin-based fibers from an aqueous solution and to convert the produced…