A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
CPhI Worldwide 2019 Floor Plan
Are you visiting CPhI Worlwide 2019 in Frankfurt?
Have a look at the floor plan before you attend the fair!
Download the full Cphi floor plan as a pdf here
See also our CPhI WorldWide Special to see some excipients topics…
Recent Approaches for Solid Dose Vaccine Delivery
Recent studies on vaccine delivery systems are exploring the possibility of replacing liquid vaccines with solid dose vaccines due to the many advantages that solid dose vaccines can offer.
These include the prospect of a needle-free…
Excipients for room temperature stable freeze-dried monoclonal antibody formulations
Sucrose is a common cyro- and lyoprotectant to stabilize labile biopharmaceuticals during freeze-drying and storage.
Sucrose based formulations require low primary drying temperatures to avoid collapse and monoclonal antibody (mAb)…
Native starch as in situ binder for continuous twin screw wet granulation
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied.
Gelatinization of pea starch occurred in the barrel of the granulator using a poorly soluble excipient (anhydrous dicalcium…
Film Coating List
Film coating is applied to a wide variety of pharmaceutical products, including tablets, pellets, granules, capsules, powders and crystals. Pharmaexcipients has put together a list of suppliers and products.
GET THE LIST HERE
Do not…
Importance of pressure plasticity during compression of probiotic tablet formulations
The usefulness, the high production rate and the cost effectiveness make tablets the dosage form of choice for oral probiotics.
Nevertheless, probiotic bacteria undergo a lot of mechanical stress during tableting which causes damage to…
Your visit at CPhI worldwide Frankfurt – Our Tips and Hints
Hey CPhI-Visitor! Have you ever been at a big german trade fair like this one? Maybe you're a pharma professional and this is your X visit, nevertheless have a look, there are many news for you, also!
Many people mistake the size and…
Organoleptic excipients used in pediatric antibiotics
Taste is a crucial factor that determines the palatability of the oral dosage form and patient compliance.
Objective
The aim of this work was to evaluate the organoleptic excipients in oral antibiotics for pediatric use marketed in…
Hot melt extruded polysaccharide blends for controlled drug delivery
Different types of hot melt extrudates were prepared based on a variety of blends of ethylcellulose with a 2nd polysaccharide, namely hydroxypropyl methylcellulose (HPMC), pectin, maize starch, inulin, maltodextrin, guar gum, and chitosan.…
Mefenamic Acid – HPMC AS HG Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt…
Mefenamic acid, a BCS class II drug, displays high permeability and low solubility, thereby exhibiting a poor dissolution profile. Hence to improve the solubility and dissolution rate of Mefenamic acid, Hot Melt Extrusion (HME) technique…
Future Perspectives for Patient-Centric Pharmaceutical Drug Product Design with Regard to Solid Oral…
In current days, the majority of healthcare systems across the industrialized countries are facing global challenges. These challenges are related to the constantly increasing costs of basic healthcare provision, with no optimal…
Novel use of insoluble particles as disintegration enhancers for orally disintegrating films
The most important issue in the design of orally disintegrating films (ODFs) is the control of the ODFs' disintegration properties.
A better understanding of the mechanisms of ingredients used to promote or disturb the disintegration…
Preparation and evaluation of orally disintegrating film containing donepezil for Alzheimer disease
The present study intended to prepare orally disintegrating film (ODF) containing donepezil (DP) for the treatment of mild to moderate alzheimer disease.
HPMC and HPC, glycerine were used as film forming agents, plasticizer,…
A unique pharmaceutical oil for solubility and oral bioavailability enhancement
White Paper New Maisine® CC
This white paper features Maisine® CC, Gattefossé’s tradename for glyceryl
monolinoleate (USP-NF), also known as corn oil mono-, di- and triglycerides.
This unique pharmaceutical oil has a long and successful…
Assessment of the effect of Cellets’ particle size on the flow in a Wurster fluid-bed coater via…
The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the…
Film coating with reliable protection, flexible film properties and high productivity
AquaPolish® PRO: Film coating with reliable protection, flexible film properties and high productivity
AquaPolish® PRO is an immediate release film coating with moisture barrier effect to prevent solid dosage forms from taking up humidity.…
The Role of Excipients in CBD Products
Cannabidiol (CBD) has become an industry panacea that’s finding its way into everything from daily supplements to herbal therapies. The market is thriving, with one in seven US consumers relying on therapeutic CBD oils. The United States…
Lipid Excipients for Cannabinoid Drug Products
With an enhanced understanding of the medicinal benefits and looming ease of regulations around
the globe, there is an expressed need for science based, adequately dosed, and age appropriate
cannabinoid medicines.
The benefits of…
A Novel Excipient for Orodispersible Minitablets
INTRODUCTION
The benefit of orodispersible minitablets (ODMT) for treating pediatrics has been demonstrated. The aim of this study is to determine the feasibility of a direct compression grade isomalt galenIQ™ 721,(BENEO-Palatinit) for…
Improved Understanding of the High Shear Wet Granulation Process under the Paradigm of Quality by…
High shear wet granulation (HSWG) is a shaping process for granulation that has been enhanced for application in the pharmaceutical industry. However, study of HSWG is complex and challenging due to the relatively poor understanding of…
Formulation of oily plant extracts using a filler-binder
Oily plant extracts are difficult to formulate into a tablet.
Isomalt is a filler-binder that helps to make this process easier and has also very good effects on palatability.
See the positive effects of using isomalt in your…
Moisture sealing film coating system for solid oral dosage forms
AquaPolish® MS: Moisture sealing film coating system for solid oral dosage forms.
Protecting moisture-sensitive substances from environmental moisture is one of the biggest challenges in the pharmaceutical and nutritional supplements…
Maisine® CC as a lipid excipient
Maisine® CC is a pharmaceutical oily vehicle used to enhance the solubility and oral bioavailability of lipophilic drugs.
Maisine® CC is derived from corn oil with a unique and highly reproducible composition in linoleic mono-di and…
Development of ibuprofen dry suspensions by hot melt extrusion
The aim of this study was to develop ibuprofen dry suspensions using hot melt extrusion to improve the in vivo performance of ibuprofen.
Ibuprofen was melt-extruded into solid dispersions with hydroxypropylmethylcellulose (HPMC) and…
Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings
Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children.
The availability of pediatric formulations is particularly lacking in…
Matrix Sustained Release Applications
CompactCel® SR - See the video on the concept and advantages of Biogrund´s one-step matrix agent
CompactCel® SR
sustained drug release
Retardation. For a sustained release profile of the drug.
Forms…
Isomalt as carrier for liquid APIs in tableting
INTRODUCTION
Many liquid active pharmaceutical ingredients (API) are formulated into solid oral drug delivery systems due to the safe way and simplicity of administration. First and foremost from a formulator´s point of view, excipient…
Alginates: From the ocean to gastroesophageal reflux disease treatment
Alginate-based pharmaceutical formulations have been successfully used to treat the symptoms of gastroesophageal reflux disease (GERD) for decades and have a rapid onset of symptom relief.
In the last twenty years, the knowledge and…
Oral Insulin – Microneedle patch drug delivery in the gut
A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.
Patients dislike shots and often cannot…
Injectable Hydrogels for Cancer Therapy over the Last Decade
The interest in injectable hydrogels for cancer treatment has been significantly growing over the last decade, due to the availability of a wide range of starting polymer structures with tailored features and high chemical versatility.…
Formulation, Development and Scale-Up of Fixed-Dose Combination Tablets Containing Zidovudine,…
The development of antiretroviral associations in a single dosage form aims to ensure good efficacy, low costs and better adherence to treatment.
Thereby, this work aimed to perform the pharmacotechnical development and stability studies…
CPhI Pharma Awards 2019 shortlist is published!
The shortlist of the CPhI Pharma Award finalists is out. The potential winners are:
Excellence in Pharma: API Development
Cambrex – Crystallisation Screening and Process Development Service
Cambrex – Innovative Synthesis of…
Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is one of the most common chronic diseases that affect the entire gastrointestinal tract (GIT) especially the colon.
Its symptoms extend from mild diarrhea, abdominal pain, and bloody diarrhea to severe…
Water-in-Oil Pickering Emulsions Stabilized by Synergistic Particle–Particle Interactions
Here, we report a novel “double Pickering stabilization” of water-in-oil (W/O) emulsions, where complex formation at the interface between Pickering polyphenol particles adsorbing from the oil side and whey protein microgel (WPM) particles…