Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix…
Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets.
All throughout the…
Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam
We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as a low-dose and poorly-soluble model drug, and…
Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of…
The main objective of this study is to develop a novel dual-purpose material based on carbon xerogel microspheres (CXMs) that permits the delayed release of cannabidiol (CBD) and the removal of aflatoxin.
The CXMs were prepared by the…
Molecular Tagging of Pharmaceutical Excipients Utilizing Applied DNA’s Technology
The study carried out by a team led by Dr. Royall at the Institute of Pharmaceutical Science, King’s College London and Dr. Altamimi from the Department of Forensic Evidence & Criminology, Dubai Police HQ, UAE, evaluated the use of DNA…
Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs
Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory…
Pharmaceutical applications of electrospinning
Development of tailor-made pharmaceutical nanofibers has gained vital prominence due to ease of fabrication and versatility of electrospinning (ES).
ES is one of the flexible and, wonderful strategies for the fabrication of nanofibers.…
Monitoring of Antimicrobial Drug Chloramphenicol Release from Electrospun Nano- and Microfiber Mats…
New strategies are continuously sought for the treatment of skin and wound infections due to increased problems with non-healing wounds. Electrospun nanofiber mats with antibacterial agents as drug delivery systems provide opportunities for…
Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy
Antimicrobial resistance is one of the most serious problems that researchers of multiple disciplines are working on.
The number of new antibiotics and their targeted structures have continuously decreased emphasizing the demand of…
Strengthening the sustained release efficiency of a formulation by employing Kollicoat® SR 30 as…
Poly(vinyl acetate) – based matrix formulations are well known for obtaining strong sustained release functionality. Depending on the solubility of the active ingredient and the required dissolution profile, pore formers need to be added…
Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug…
We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a…
Synthesis and characterization of acetyl curcumin-loaded core/shell liposome nanoparticles via an…
Despite substantial advancements in divergent drug delivery systems (DDS), there is still room for novel and innovative nanoparticle-mediated drug delivery methodologies such as core/shell liposomes to deliver drugs in a kinetically…
Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid…
Haemanthamine (HAE) has been proven as a potential anticancer agent. However, the therapeutic use of this plant-origin alkaloid to date is limited due to the chemical instability and poorly water-soluble characteristics of the agent. To…
Developing methodology to evaluate the oral sensory features of pharmaceutical tablet coatings
Acceptability of medicines is critical for effective pharmacotherapy.
The aim of this study was to investigate the oral sensory properties of tablet coatings to determine how mouthfeel can improve acceptability. A randomised double-blind…
BIOGRUND achieves a major milestone in the company’s history
Biogrund proudly looks back at the opening of the new BIOGRUND US location in Kentucky, USA. The new premises provide space for sales, customer service, technical service, research & development, laboratory and production.
Biogrund…
Synthetic networks with tunable responsiveness, biodegradation, and molecular recognition for…
Formulations and devices for precision medicine applications must be tunable and multiresponsive to treat heterogeneous patient populations in a calibrated and individual manner.
We engineered modular poly(acrylamide-co-methacrylic acid)…
Excipients for Parenteral Use
Discover BASF’s wide range of excipients for parenteral use meeting the highest quality standards as well as BASF’s unparalleled experience in quality and regulatory affairs.
Click on the poster for a full view:
PDF Download:…
Rational Development of Liposomal Hydrogels: A Strategy for Topical Vaginal Antiretroviral Drug…
HIV/AIDS stands as a global burden, and vaginal microbicides constitute a promising strategy for topical pre-exposure prophylaxis.
Preceding the development of a microbicide containing tenofovir disoproxil fumarate (TDF) and…
Unidirectional drug release from 3D printed mucoadhesive buccal films using FDM technology
Oromucosal delivery of active pharmaceutical ingredients provides an attractive alternative route of administration, due to avoidance of the first pass effect and improved patient compliance. In the current work, fused deposition modelling…
Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and…
Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release.
With this in view, we aimed…
Direct Compression of Lactase Tablets with PROSOLV® EASYtab Nutra
The aim of this study was the development of lactase tablets that can be produced by direct compression. In order to avoid stability problems of the enzyme lactose, caused by high temperature and moisture, direct compression is the most…
Synergising excipients to boost skin delivery: A case study with lidocaine hydrochloride
In this study lidocaine hydrochloride (LID HCl), a local anesthetic agent, was used to evaluate the solubilizing performance of each CPE. An in-vitro permeation study was conducted using vertical diffusion cells (Franz cells, Strat-M…
Achieving gastroresistance without coating: Formulation of capsule shells from enteric polymers
Capsules are a widely used oral dosage form due to their simplicity and ease of manufacture.
They are equally popular for both pharmaceutical and nutraceutical products and since they do not need extensive formulation development, it is…
EU Excipient Risk Assessment Guidelines
The Challenges of Determining Excipient Quality
In the past years, the critical role of excipients in drug production has come into focus.
This meant shaking off the long prevailing perception of excipients being passive additions to an…
Nanoparticles from Gantrez® AN-poly(ethylene glycol) conjugates as carriers for oral delivery of…
The oral delivery of docetaxel (DTX) is challenging due to a low bioavailability, related to an important pre-systemic metabolism. With the aim of improving the bioavailability of this cytotoxic agent, nanoparticles from conjugates based on…
Semi-Solid Topical Formulary
Topical formulations may be used to deliver active pharmaceutical ingredients (APIs) to or through the skin. These formulations typically possess a relatively soft, spreadable consistency and are often formulated as either water-in-oil or…
DOE Case Studies for Industrial Applications
An integrated approach based on QbD and PAT provides a systematic and innovative framework for product development, manufacturing, and quality risk management.
In this context, the significance of the outcome of design of experiments…
Lipid-based formulations in soft gelatin capsules
Gattefossé published a new Tech` Chats video on Lipid-based formulations in soft gelatin capsules.
Following questions are answered beside others in the 7 min video:
Why using soft gelatin capsules for lipid-based formulations?…
Applications of mesoporous material for drug delivery
In recent years mesoporous silica is gaining attention because of their emerging applications in drug delivery.
Since their first appearance in materials science in the 1990s, these inorganic carriers have been successfully used in other…
Liposomes augment biological benefits of curcumin for multitargeted skin therapy
Curcumin, a multi-targeting pharmacologically active compound, is a promising molecule for the treatment of skin inflammation and infection in chronic wounds.
However, its hydrophobic nature remains to be a challenge in development of…
Effects of Electrospinning on the Viability of Ten Species of Lactic Acid Bacteria in Poly(Ethylene…
Lactic acid bacteria can have beneficial health effects and be used for the treatment of various diseases. However, there remains the challenge of encapsulating probiotics into delivery systems with a high viability and encapsulation…
Dual Drug Nanocrystals loaded Microparticles for Fixed Dose Combination of Simvastatin and Ezetimibe
Dual drug nanocrystals loaded Nano Embedded Microparticles (DNEM) were prepared for fixed dose combination of Simvastatin (SIM) and Ezetimibe (EZE) using NanoCrySP technology.
The purpose was to generate nanonized SIM and EZE dispersed…
CPhI China – Post Show Report
Hosted by Informa Markets and the China Chamber of Commerce for Import & Export of Medicines & Health Products (CCCMHPIE) the event was co-sponsored by Sinoexpo Informa Markets and held its 19th edition this year.
Since its first…
Development and Characterization of Eudragit®-Based Electrospun Nanofibrous Mats and Their…
Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly absorbed in the stomach and in the upper small…
Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects
The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions.
In this study, a series of amorphous solid dispersions (ASD) of…