A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
CPhI China – Post Show Report
Hosted by Informa Markets and the China Chamber of Commerce for Import & Export of Medicines & Health Products (CCCMHPIE) the event was co-sponsored by Sinoexpo Informa Markets and held its 19th edition this year.
Since its first…
Development and Characterization of Eudragit®-Based Electrospun Nanofibrous Mats and Their…
Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic, is practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly absorbed in the stomach and in the upper small…
Molecular Interactions for the Curcumin-Polymer Complex with Enhanced Anti-Inflammatory Effects
The molecular interactions between compound and polymeric carriers are expected to highly contribute to high drug load and good physical stability of solid dispersions.
In this study, a series of amorphous solid dispersions (ASD) of…
Preclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3…
Background
Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investigated Akt/mTOR…
Effect of Sustained Release Polymers on Drug Release Profile of Aceclofenac Tablets –…
Aim: The sustained release tablets of Aceclofenac were prepared and evaluated for the sustained release drug profile with an aim to reduce dosing frequency and provide patient compliance.
Materials and Method: The tablets were prepared…
A Novel Framework to Aid the Development of Design Space across Multi-Unit Operation Pharmaceutical…
The fundamental principle of Quality by Design (QbD) is that the product quality should be designed into the process through an upstream approach, rather than be tested in the downstream.
The keystone of QbD is process modeling, and…
World Pharmacists Day 2019
Congratulations and sincere thanks to the Pharmacists
all over the world for your daily great work!
On the 25th of September is the annual World Pharmacists Day.
This year's theme is "Safe and effective medicines for all", it…
Controlled dissolution of freeform 3D printed carbohydrate glass scaffolds in hydrogels using a…
Freeform 3D printing combined with sacrificial molding promises to lead advances in production of highly complex tubular systems for biomedical applications. Here we leverage a purpose-built isomalt 3D printer to generate complex channel…
Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT) for…
A large proportion of pharmaceutical compounds exhibit poor water solubility, impacting their delivery.
These compounds can be passively encapsulated in the lipid bilayer of liposomes to improve their water solubility, but the loading…
Water-insoluble polymers as binders for pellet drug layering: Effect on drug release and performance…
The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellet drug layering to extend the drug release. Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol…
Selection Of A Filler For Tablets Manufactured With Direct Compression Method Containing Dry Ginger…
The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment…
Development of Robust Orally Dispersible Powder Formulations
The poster on the development of a robust orally dispersible powder formulation for peadiatrics was presented by Graeme Macleod during the EUPFi in Malmö.
See the full Poster of SPI Pharma
The conclusion
ODP formulation requires…
Soluplus® – For better solubility and bioavailability
Did you know that Soluplus® also solubilizes drugs processed by wet granulation?
Try Soluplus® and experience a new dimension in solubility and bioavailability enhancement.
Soluplus® is an innovative excipient that enables new levels of…
Microdosed midazolam in a buccal film
Cytochrome P450 3A (CYP3A) isozymes metabolize about 50% of all marketed drugs. Their activity can be modulated up to 400-fold, which has great impact on individual dose requirements for CYP3A substrates. The activity of CYP3A can be…
Development of sublingual spray formulation containing ondansetron hydrochloride dihydrate
Ondansetron is an antiemetic agent which is used primarily in hospital settings to prevent nausea and vomiting while patient is on chemotherapy or radiotherapy.
Oral tablets currently available in the market exhibit a rather slow onset…
Halal certified oelechemicals from BASF
BASF has more products that officially received Halal certifications in the oleochemical products portfolio. Check out the image below for the complete list of Oleochemical products with halal certifications
Fundamental evaluation and optimization of porous spherical silica for developing functional fine…
Particle coating, a taste-masking technique for drugs, is limited by its long manufacturing time, which is caused by the decrease in the spray rate required to prevent particle agglomeration.
Mesoporous silica particles, which have a…
The influence of isomalt particle morphology on tabletability after roll compaction/dry granulation
The influence of different isomalt particle morphologies on dry granule and tablet properties was investigated. Primary crystals, milled particles and agglomerates were tableted after roll compaction/dry granulation and compared to the…
Novel anti-cancer nanomedicine for efficient chemotherapy
Researchers at the University of Helsinki in collaboration with researchers from Åbo Akademi University (Finland) and Huazhong University of Science and Technology (China) have developed a new anti-cancer nanomedicine for targeted cancer…
Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food…
Background and Objectives
The importance of quercetin and flavonoids in the diet and as food supplements is well known, and literature studies support their potential use to treat several human diseases. Many beneficial properties have…
Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during…
Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition,…
Olopatadine hydrochloride loaded Kollidon® SR nanoparticles for ocular delivery: Nanosuspension…
Introduction
Allergic eye diseases includes a spectrum of diseases, with each state being characterized by a complicated immunopathology. In the present study, polymeric Kollidon® SR nanoparticles loaded with olopatadine hydrochloride…
The JRC releases new certified reference material for nanoparticle size and shape analysis…
The JRC of the European Commission (EC) has produced its first Certified Reference Material (CRM) for quality control of measurements of nanoparticle size and shape parameters by electron microscopy.
The CRM (ERM-FD103), which has been…
Solubility enhancement of nimodipine through preparation of Soluplus® dispersions
The present work aims to enhance the water solubility of nimodipine, a hydrophobic drug, using a solid dispersion (SD) technique. Soluplus® as a novel hydrophilic polymeric carrier was used. Nimodipine-Soluplus® SDs (1:10) were prepared by…
Comparison of PEGylated and non-PEGylated proticles: An in vitro and in vivo study
The development of so-called Proticles opens attractive possibilities for new drug delivery systems.
Proticles are nanoparticles (NPs), which are formed by self-assembly of negatively charged oligonucleotides in combination with the…
Quantifying the loading capacity of a carrier-based DPI formulation and its dependence on the…
Non-segregating ordered powder mixtures constituted by a coarse carrier fraction and finer components are at the basis of dry powders for inhalation pharmaceuticals.
The estimation of the loading capacity, i.e. how many fines can be…
An Update of Moisture Barrier Coating for Drug Delivery
Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages.
Moisture barrier film coating is one of the most appropriate and effective approaches…
Immediate-released pelletized solid dispersion containing fenofibrate: Formulation, in vitro…
There have been many strategies to increase solubility, dissolution rates, and oral bioavailability of fenofibrate such as micronization, nanonization, solid dispersion, and emulsion so far. To our knowledge, only first three technologies…
Microencapsulation Curcuminoids for Effective Delivery in Pharmaceutical Application
Curcuminoids have been long proven to possess antioxidant, anti-inflammatory and antibacterial properties which are crucial in their role as a pharmacological active agent.
However, its poor solubility, high oxidative degradation, light…
Kollidon® 30 – The original from BASF
Kollidon® 30 is the solution for endless opportunities in pharmaceutical formulations – use it as a binder, pore former, stabilizer, thickener, solubilizing agent, crystallization inhibitor and countless more.
Click on the poster to see it…
Cinnamyl O-amine functionalized chitosan as a new excipient in direct compressed tablets with…
The use of chitosan as a potential excipient in pharmaceutical formulations for the delivery of drugs produced via direct compression tableting has been investigated.
Chitosan, N-cinnamyl substituted O-amine functionalized chitosan…
Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions: The effect of…
The aim of this study was to evaluate the choice of polymer and polymer level on the performance of the microstructure and wettability of hot-melt extruded solid dispersion of Glyburide (Gly) as a model drug.
The produced solid…
Pharma-MMC, Pharmaceutical grade Mesoporous Magnesium Carbonate
Pharma-MMC is a proprietary drug delivery technology for amorphous stabilization and solubility enhancement of drug substances and for unique drug formulations - addressing unmet industry needs:
High drug-load (up to 50% w/w)
Long…
Influence of mechanical and thermal energy on nifedipine amorphous solid dispersions prepared by hot…
Hot melt extrusion (HME) has been used to prepare solid dispersions, especially molecularly dispersed amorphous solid dispersions (ASDs) for solubility enhancement purposes. The energy generated by the extruder in the form of mechanical and…