Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Population balance modeling of formation and breakage of nanoparticle agglomerates in a spouted bed
Abstract
A population balance framework for fluidization of Al2O3 nano-agglomerates in a ProCell-type spouted bed considering agglomeration and breakage phenomena is developed. An equipartition of kinetic energy (EKE kernel) is used to…
Development of nanoemulsion loaded acyclovir nanogel for transdermal delivery and its evaluation
Abstract
Acyclovir (ACV) is an antiviral drug that is primarily used to treat herpes zoster virus (HSV) infections. HSV infections in deeper regions of the skin, i.e., nerve junctions, and appeared as a red spot on the upper part of the…
Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain…
Abstract
This review summarizes the recent findings on the development of different types of single and multitarget nanoparticles for disease detection and drug delivery to the brain, focusing on promising active principles encapsulated…
Cancer nanomedicine: emergence, expansion, and expectations
The introduction of cancer nanomedicine has substantially enhanced the effectiveness of cancer treatments. Nano-formulations are becoming more prevalent among other treatment methods due to their improved therapeutic efficacy and low…
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for…
Objectives
Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the feasibility of a new system…
Preparation, optimization and evaluation of Osthole transdermal therapeutic system
In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the…
Predicting the hyperelastic properties of alginate-gelatin hydrogels and 3D bioprinted…
Additive manufacturing has been widely used in tissue engineering, as 3D bioprinting enables fabricating geometrically complicated replacements for different tissues and organs. It is vital that the replacement mimics the specific…
Oral fast-dissolving risperidone loaded electrospun nanofiber drug delivery systems for…
Abstract
Risperidone is an antipsychotic drug classified as BCS Class II with low solubility at physiological pH and orally used in the treatment of schizophrenia. Electrospinning is one of the newest fabrication methods used for the…
Engineering a novel water-in-oil biocompatible microemulsion system for the ocular delivery of…
Due to their unique characteristics, microemulsions (ME) represent one of the most promising delivery systems which can conquer poor ocular drug bioavailability providing long residence time. Development of a ME system, relying on the use…
3D printed capsule shells for personalized dosing of cyclosporine-loaded SNEDDS
Abstract
Cyclosporine (CsA) is a potent immunosuppressant agent that has been used since 1980 for the treatment of various autoimmune diseases and is extensively used to enhance the survival rate of patients and grafts following organ…
Self-Emulsifying Drug Delivery of Khellin for Improving Its Oral Bioavailability
Self-emulsifying drug delivery system (SEDDS) is extensively used for enhancing the solubility, dissolution, and pharmacokinetics of poorly soluble drugs. Khellin is a natural product with multiple pharmacological activities and has…
Quality by Design Galvanized development of resveratrol loaded PLGA nanoparticles: In vitro and Ex…
Melanoma is a lethal form of skin cancer, which progresses with poor prognosis. The melanoma tumors are highly metastatic in nature, which often leads to tumorigenesis in lungs and brain tissues. Invasion and migration are mainly…
Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer…
Abstract
Background and Objective
There are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased adherence to immediate-release (IR) formulations due to the high number of doses…
Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study
The aim of this study was to evaluate the effect of film-forming polymer solutions of different concentrations and pH values, either associated or not with sodium fluoride (F; 225 ppm F−), when applied during the initial stage of salivary…
Orodispersible Films: Current Innovations and Emerging Trends
Abstract
Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various…
Quality by design aided self-nano emulsifying drug delivery systems development for the oral…
The primary objective of the research effort is to establish efficient solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for benidipine (BD) through the systematic application of a quality-by-design (QbD)-based paradigm. Utilizing…
3D Printing Emerging Technologies and Functionality of Polymeric Excipients in Drug Product…
See the new book, edited by Michael A. Repka, Nigel Langley
Covers regulatory and manufacturing aspects of 3D printing in drug development
Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D…
Liposomal Encapsulation of Amoxicillin via Microfluidics with Subsequent Investigation of the…
With an increasing concern of global antimicrobial resistance, the efforts to improve the formulation of a narrowing library of therapeutic antibiotics must be confronted. The liposomal encapsulation of antibiotics using a novel and…
Formulation and evaluation of dabigatran loaded microballoons for prolonged drug release
The objective of the present investigation was to formulate microballoons loaded with dabigatran in the polymeric core for achieving sustained release and hence improved bioavailability. Microballoons loaded with dabigatran in the polymer…
ApoE – functionalization of nanoparticles for targeted brain delivery – a feasible…
Abstract
The blood–brain barrier (BBB) poses a major obstacle in the treatment of all types of central nervous system (CNS) diseases. Small interfering RNA (siRNA) offers in principle a promising therapeutic approach by downregulating…
Semisolid Extrusion Printing and 3D Bioprinting
Emerging Technologies and Functionality of Polymeric Excipients in Drug Product Development
Covers regulatory and manufacturing aspects of 3D printing in drug development
Particular focus on hot melt extrusion and extruded filaments…
Understanding the impact of mannitol on physical stability and aerosolization of spray-dried protein…
Abstract
Pulmonary delivery of protein-based therapeutics, including antibodies, is a promising option for treating respiratory diseases. Spray drying is a widely used method for producing dry powder formulations with mannitol being a…
Liquid API Feeding in Pharmaceutical HME: Novel Options in Solid Dosage Manufacturing
Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the pharmaceutical industry and can be implemented in a continuous manufacturing line. However, the conventional way of active pharmaceutical ingredient (API)…
3D Printing Emerging Technologies and Functionality of Polymeric Excipients in Drug Product…
See the new book, edited by Michael A. Repka, Nigel Langley
Covers regulatory and manufacturing aspects of 3D printing in drug development
Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D…
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery…
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effects. Dissolving microneedle has sharp tips and short length, which overcome patients’ pain and improve transdermal…
Leveraging spray drying technique for advancing biologic product development – A mini review
Over the last 15 years, spray drying (SD), as an alternative to lyophilization, to manufacture and increase the stability of biologics has demonstrated promising outcomes. Pharmaceutical companies, on the other hand, have yet to expand…
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances
Abstract
Purpose
Continuous wet granulation and drying require an adequate process control strategy to ensure the product quality. The most important critical quality attributes of dried granules are the granule size distribution and…
Fused Deposition Modelling 3D printing and solubility improvement of BCS II and IV active…
Abstract
In the field of pharmaceutical research and development, Fused Deposition Modelling (FDM) 3D printing (3DP) has aroused growing interest within the last ten years. The use of thermoplastic polymers, combined with the melting…
A Chewing Study of Abuse-Deterrent Tablets Containing Polyethylene Oxide Using a Robotic Simulator
Abuse-deterrent formulations (ADFs) refer to formulation technologies aiming to deter the abuse of prescription drugs by making the dosage forms difficult to manipulate or extract the opioids. Assessments are required to evaluate the…
The Development of Lipid-Based Sorafenib Granules to Enhance the Oral Absorption of Sorafenib
Abstract
Sorafenib (SFN) is an anticancer multi-kinase inhibitor with great therapeutic potential. However, SFN has low aqueous solubility, which limits its oral absorption. Lipids and surfactants have the potential to improve the…
Formulation development and evaluation of fluvastatin loaded transethosomes: Characterization,…
Psoriasis, a common immune-mediated chronic inflammatory disease, may arise from genetic, epigenetic, and immune system factors. Current medications focus on symptom relief, presenting a challenge in discovering new compounds or methods for…
Formulation and characterization of medicated chewing gum containing zingiberine for treatment of…
The objective of this work was to formulate zingiberine as medicated chewing gum for improving its bioavailability. The objective was achieved by isolating zingiberine form ginger oil and formulating chewing gum using zein as the gum base…
3D Printing Emerging Technologies and Functionality of Polymeric Excipients in Drug Product…
See the new book, edited by Michael A. Repka, Nigel Langley
Covers regulatory and manufacturing aspects of 3D printing in drug development
Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D…
pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria to the colon remains a challenge. Furthermore, current oral formulations, such as lyophilized bacterial capsules or…